Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Travis Stams"'
Autor:
Jonathan R. LaRochelle, Michelle Fodor, Vidyasiri Vemulapalli, Morvarid Mohseni, Ping Wang, Travis Stams, Matthew J. LaMarche, Rajiv Chopra, Michael G. Acker, Stephen C. Blacklow
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Activating mutations of the non-receptor protein tyrosine phosphatase SHP2 can cause cancer. Here the authors present the crystal structure of SHP2E76K, the most frequent cancer-associated SHP2 mutation, which adopts an open-state structure and show
Externí odkaz:
https://doaj.org/article/d0fced2ac7bd48d8ba126a11fc5bed5f
Autor:
Zineb Mounir, Joshua M Korn, Thomas Westerling, Fallon Lin, Christina A Kirby, Markus Schirle, Gregg McAllister, Greg Hoffman, Nadire Ramadan, Anke Hartung, Yan Feng, David Randal Kipp, Christopher Quinn, Michelle Fodor, Jason Baird, Marie Schoumacher, Ronald Meyer, James Deeds, Gilles Buchwalter, Travis Stams, Nicholas Keen, William R Sellers, Myles Brown, Raymond A Pagliarini
Publikováno v:
eLife, Vol 5 (2016)
The TMPRSS2:ERG gene fusion is common in androgen receptor (AR) positive prostate cancers, yet its function remains poorly understood. From a screen for functionally relevant ERG interactors, we identify the arginine methyltransferase PRMT5. ERG recr
Externí odkaz:
https://doaj.org/article/c4fb9b17bde6451983fdc615d4bf193b
Autor:
Naomi N. K. Kreamer, Rajiv Chopra, Ruth E. Caughlan, Doriano Fabbro, Eric Fang, Patricia Gee, Ian Hunt, Min Li, Barbara C. Leon, Lionel Muller, Brian Vash, Angela L. Woods, Travis Stams, Charles R. Dean, Tsuyoshi Uehara
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-1 (2018)
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Externí odkaz:
https://doaj.org/article/a4e35beabe6845109a733f8dfc8a0e04
Autor:
Zachary J. Hauseman, Michelle Fodor, Anxhela Dhembi, Jessica Viscomi, David Egli, Melusine Bleu, Stephanie Katz, Eunyoung Park, Dong Man Jang, Kathryn A. Porter, Fabian Meili, Hongqiu Guo, Grainne Kerr, Sandra Mollé, Camilo Velez-Vega, Kim S. Beyer, Giorgio G. Galli, Saveur-Michel Maira, Travis Stams, Kirk Clark, Michael J. Eck, Luca Tordella, Claudio R. Thoma, Daniel A. King
Publikováno v:
Nature. 609:416-423
RAS–MAPK signalling is fundamental for cell proliferation and is altered in most human cancers1–3. However, our mechanistic understanding of how RAS signals through RAF is still incomplete. Although studies revealed snapshots for autoinhibited an
Autor:
Victoriano Tamez, Brant Firestone, Michelle Fodor, Martin Sendzik, Michael G. Acker, Stan Spence, Matthew J. LaMarche, Mitsunori Kato, Chen Liu, Christopher Towler, Ping Wang, Ho Man Chan, Eric McNeill, Shumei Liu, Morvarid Mohseni, Sarah Williams, Zhouliang Chen, Gang Liu, Bing Yu, Robert Koenig, Huaixiang Hao, Ying-Nan Chen, Murphy Hentemann, Ritesh Bhanudasji Tichkule, Hongyun Wang, Jorge Garcia Fortanet, Laura R. LaBonte, Jeffrey T. Bagdanoff, Travis Stams, Patrick James Sarver
Publikováno v:
Journal of Medicinal Chemistry. 62:1793-1802
Protein tyrosine phosphatase SHP2 is an oncoprotein associated with cancer as well as a potential immune modulator because of its role in the programmed cell death PD-L1/PD-1 pathway. In the preceding manuscript, we described the optimization of a fu
Autor:
Kelly Slocum, Jianmei Fan, Michael Dore, Palermo Mark G, Zhan Deng, Bakary-Barry Toure, Jorge Garcia-Fortanet, Dyuti Majumdar, Martin F. Hentemann, Nick Keen, Suzanne Zhu, Christopher Towler, Michael Shultz, William R. Sellers, Simon Mathieu, Denise Grunenfelder, Robert Koenig, Douglas C. Bauer, Shumei Liu, Jay Larrow, Victoriano Tamez, David Dunstan, Andreea Argintaru, Timothy Michael Ramsey, Zhouliang Chen, Gang Liu, Ying-Nan Chen, Rukundo Ntaganda, Bing Yu, Joanna Slisz, Hongyun Wang, Pascal D. Fortin, Christopher Sean Straub, Ji-Hu Zhang, Ping Wang, Laura R. LaBonte, Mitsunori Kato, Matthew J. Meyer, Fan Yang, Patrick James Sarver, Samuel B. Ho, Brant Firestone, Rajesh Karki, John F. Reilly, Troy Smith, Ho Man Chan, Cary Fridrich, John William Giraldes, Julie Boisclair, Chen Christine Hiu-Tung, Meir Glick, Zhao B. Kang, Morvarid Mohseni, Lawrence Blas Perez, Michael G. Acker, Sarah Williams, Matthew J. LaMarche, Martin Sendzik, Michelle Fodor, Huia-Xiang Hao, Peter Fekkes, Minying Pu, Travis Stams, Stanley Spence, Andriana Jouk
Publikováno v:
Journal of medicinal chemistry. 63(22)
SHP2 is a nonreceptor protein tyrosine phosphatase encoded by the PTPN11 gene and is involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also plays an important role in the programed cell death pathway (PD-1/PD-L1). As an
Autor:
Brian Edward Vash, Naomi N. K. Kreamer, Lionel Muller, Ian Hunt, Tsuyoshi Uehara, Charles R. Dean, Patricia Gee, Ruth E. Caughlan, Barbara C. Leon, Doriano Fabbro, Angela L. Woods, Eric Fang, Min Li, Travis Stams, Rajiv Chopra
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports
Scientific Reports
Phosphorylation of Pseudomonas aeruginosa lipopolysaccharide (LPS) is important for maintaining outer membrane integrity and intrinsic antibiotic resistance. We solved the crystal structure of the LPS heptose kinase WaaP, which is essential for growt
Autor:
Sara J. Buhrlage, Jonathan R. LaRochelle, Morvarid Mohseni, Vidyasiri Vemulapalli, Xiaoxi Liu, Matthew J. LaMarche, Jana M. Ellegast, Michael G. Acker, Michelle Fodor, Kimberly Stegmaier, Stephen C. Blacklow, Travis Stams
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:6479-6485
The PTPN11 oncogene encodes the cytoplasmic protein tyrosine phosphatase SHP2, which, through its role in multiple signaling pathways, promotes the progression of hematological malignancies and other cancers. Here, we employ high-throughput screening
Autor:
Christopher Towler, Andriana Jouk, Murphy Hentemann, Matthew J. LaMarche, Bing Yu, Jorge Garcia Fortanet, Michelle Fodor, Hongyun Wang, Sarah Williams, Morvarid Mohseni, Shumei Liu, Huaixiang Hao, Ritesh Bhanudasji Tichkule, Ying-Nan Chen, Chen Liu, Ping Wang, Patrick James Sarver, Stan Spence, Laura R. LaBonte, Jeffrey T. Bagdanoff, Brant Firestone, Michael Shultz, Martin Sendzik, Eric McNeill, Zhouliang Chen, Gang Liu, Victoriano Tamez, Robert Koenig, Michael G. Acker, Ho Man Chan, Travis Stams, Mitsunori Kato
Publikováno v:
Journal of medicinal chemistry. 62(7)
Autor:
Michael G. Acker, Ping Wang, Brant Firestone, Ying-Nan Chen, Shumei Liu, Jorge Garcia Fortanet, Michael Shultz, Robert Koenig, Ho Man Chan, Mitsunori Kato, Murphy Hentemann, Rukundo Ntaganda, Patrick James Sarver, Laura R. LaBonte, Martin Sendzik, Jeffrey T. Bagdanoff, Zhouliang Chen, Michelle Fodor, Movarid Mohseni, Travis Stams, Christopher Towler, Troy Smith, Stan Spence, Hongyun Wang, Matthew J. LaMarche, Michael Dore, Sarah Williams
Publikováno v:
Journal of medicinal chemistry. 62(7)