Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Travis P. Johnson"'
Autor:
Xiuxiu Yang, Debolina Chatterjee, Justin L. Couetil, Ziyu Liu, Valerie D. Ardon, Chao Chen, Jie Zhang, Kun Huang, Travis S. Johnson
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Colon cancer (CC) is the second most common cause of cancer deaths and the fourth most prevalent cancer in the United States. Recently cholesterol metabolism has been identified as a potential therapeutic avenue due to its consistent association with
Externí odkaz:
https://doaj.org/article/860804c4659a4c7b9c6e428a8b858161
Autor:
Travis S. Johnson, Parvathi Sudha, Enze Liu, Nathan Becker, Sylvia Robertson, Patrick Blaney, Gareth Morgan, Vivek S. Chopra, Cedric Dos Santos, Michael Nixon, Kun Huang, Attaya Suvannasankha, Mohammad Abu Zaid, Rafat Abonour, Brian A. Walker
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Multiple Myeloma is an incurable plasma cell malignancy with a poor survival rate that is usually treated with immunomodulatory drugs (iMiDs) and proteosome inhibitors (PIs). The malignant plasma cells quickly become resistant to these agent
Externí odkaz:
https://doaj.org/article/ffcdb5a5e6fa4b48a7e4c40b4a3019b8
Autor:
Tahlia L. Fulton, Joshua N. Johnstone, Jing J. Tan, Krithika Balagopal, Amy Dedman, Andrea Y. Chan, Travis K. Johnson, Christen K. Mirth, Matthew D. W. Piper
Publikováno v:
Open Biology, Vol 14, Iss 8 (2024)
Nutrition and resilience are linked, though it is not yet clear how diet confers stress resistance or the breadth of stressors that it can protect against. We have previously shown that transiently restricting an essential amino acid can protect Dros
Externí odkaz:
https://doaj.org/article/689d12d7c11448ec965f1ea5f2fa152b
Autor:
Felipe Martelli, Annelise Quig, Sarah Mele, Jiayi Lin, Tahlia L. Fulton, Mia Wansbrough, Christopher K. Barlow, Ralf B. Schittenhelm, Travis K. Johnson, Matthew D. W. Piper
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Drosophila melanogaster is unique among animal models because it has a fully defined synthetic diet available to study nutrient-gene interactions. However, use of this diet is limited to adult studies due to impaired larval development and s
Externí odkaz:
https://doaj.org/article/1402184d5678404da39f83a9a59792eb
Autor:
Rashmita Basu, Andrew J. Elmendorf, Betty Lorentz, Connor A. Mahler, Olivia Lazzaro, Britany App, Shudi Zhou, Yura Yamamoto, Mya Suber, Jamie C. Wann, Hyun Cheol Roh, Patrick L. Sheets, Travis S. Johnson, Jonathan N. Flak
Publikováno v:
Molecular Metabolism, Vol 84, Iss , Pp 101951- (2024)
Objective: Hypothalamic signals potently stimulate energy expenditure by engaging peripheral mechanisms to restore energy homeostasis. Previous studies have identified several critical hypothalamic sites (e.g. preoptic area (POA) and ventromedial hyp
Externí odkaz:
https://doaj.org/article/c026ee79725f4b378449c51c7e720e70
Autor:
Yichen Sun, Moyi Li, Junhua Geng, Sibie Meng, Renjun Tu, Yan Zhuang, Mingkuan Sun, Menglong Rui, Mengzhu Ou, Guangling Xing, Travis K. Johnson, Wei Xie
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Neuroligins are transmembrane cell adhesion proteins well-known for their genetic links to autism spectrum disorders. Neuroligins can function by regulating the actin cytoskeleton, however the factors and mechanisms involved are still largel
Externí odkaz:
https://doaj.org/article/423bb60b32da476f964f51eedc55c503
Autor:
Li Lin, Rashmita Basu, Debolina Chatterjee, Andrew T. Templin, Jonathan N. Flak, Travis S. Johnson
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract High-fat diet (HFD) is associated with Alzheimer’s disease (AD) and type 2 diabetes risk, which share features such as insulin resistance and amylin deposition. We examined gene expression associated with astrocytes and microglia since dys
Externí odkaz:
https://doaj.org/article/42ce770965274dccad3fda5f1b2e0b9e
Autor:
Felipe Martelli, Jiayi Lin, Sarah Mele, Wendy Imlach, Oguz Kanca, Christopher K. Barlow, Jefferson Paril, Ralf B. Schittenhelm, John Christodoulou, Hugo J. Bellen, Matthew D.W. Piper, Travis K. Johnson
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113861- (2024)
Summary: Inherited metabolic disorders are a group of genetic conditions that can cause severe neurological impairment and child mortality. Uniquely, these disorders respond to dietary treatment; however, this option remains largely unexplored becaus
Externí odkaz:
https://doaj.org/article/37055522b2c8443f94ea3b03560bb55f
Publikováno v:
Journal of Clinical and Translational Science, Vol 8, Pp 93-93 (2024)
OBJECTIVES/GOALS: The 'field effect' is a concept in pathology that pre-malignant tissue changes forecast health. Spatial transcriptomics could detect these changes earlier than histopathology, suggesting new early cancer screening methods. Knowing h
Externí odkaz:
https://doaj.org/article/61f35b2175334fe2ac98c08b0cafbf68
Autor:
Travis S. Johnson, Christina Y. Yu, Zhi Huang, Siwen Xu, Tongxin Wang, Chuanpeng Dong, Wei Shao, Mohammad Abu Zaid, Xiaoqing Huang, Yijie Wang, Christopher Bartlett, Yan Zhang, Brian A. Walker, Yunlong Liu, Kun Huang, Jie Zhang
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-23 (2022)
Abstract We propose DEGAS (Diagnostic Evidence GAuge of Single cells), a novel deep transfer learning framework, to transfer disease information from patients to cells. We call such transferrable information “impressions,” which allow individual
Externí odkaz:
https://doaj.org/article/a416f2c8e20d4df68f061235c38432e6