Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Travis McMurphy"'
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 7, Iss C, Pp 83-95 (2017)
Mutations in the melanocortin-4-receptor (MC4R) comprise the most common monogenic form of severe early-onset obesity, and conventional treatments are either ineffective long-term or contraindicated. Immediately downstream of MC4R—in the pathway fo
Externí odkaz:
https://doaj.org/article/fda2f35af3d741aaa5a014f371b0b9bb
Autor:
Travis McMurphy, Run Xiao, Daniel Magee, Andrew Slater, Lennart Zabeau, Jan Tavernier, Lei Cao
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89895 (2014)
Environmental and genetic activation of a brain-adipocyte axis inhibits cancer progression. Leptin is the primary peripheral mediator of this anticancer effect in a mouse model of melanoma. In this study we assessed the effect of a leptin receptor an
Externí odkaz:
https://doaj.org/article/321510f925f24dcdb7e1219fb9726f09
Autor:
Xianglan Liu, Daniel Magee, Chuansong Wang, Travis McMurphy, Andrew Slater, Matthew During, Lei Cao
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)
Adipose tissue plays an essential role in metabolic homeostasis and holds promise as an alternative depot organ in gene therapy. However, efficient methods of gene transfer into adipose tissue in vivo have yet to be established. Here, we assessed the
Externí odkaz:
https://doaj.org/article/3d8d90e1c95e45e3b9a160f21ab2b86b
Autor:
Lei Cao, Nicholas J. Queen, Wei Huang, Travis McMurphy, Ryan K. Wilkins, Seemaab Ali, Bhavya Appana
Publikováno v:
Compr Psychoneuroendocrinol
Comprehensive Psychoneuroendocrinology, Vol 4, Iss, Pp 100013-(2020)
Comprehensive Psychoneuroendocrinology, Vol 4, Iss, Pp 100013-(2020)
Background/Objectives Environmental enrichment (EE) is a physiological model to investigate brain-fat interactions. We previously discovered that EE activates the hypothalamic-sympathoneural adipocyte (HSA) axis via induction of brain-derived neurotr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c61a03ef98d034a951359d4787bc37
https://pubmed.ncbi.nlm.nih.gov/35355831
https://pubmed.ncbi.nlm.nih.gov/35355831
Publikováno v:
Aging Cell
The aging process and age‐related diseases all involve perturbed energy adaption and impaired ability to cope with adversity. Brain‐derived neurotrophic factor (BDNF) in the hypothalamus plays important role in regulation of energy balance. Our p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af4dda179f0171a7a90586b337b3e216
http://europepmc.org/articles/PMC6413658
http://europepmc.org/articles/PMC6413658
Publikováno v:
Molecular Therapy. 24:1062-1069
Recombinant adeno-associated virus (rAAV) vectors are attractive vehicles for gene therapy. Gene delivery to the adipose tissue using naturally occurring AAV serotypes is less successful compared to liver and muscle. Here, we demonstrate that oral ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e17399f5800e2a4cc006d53f5ca136b
https://doi.org/10.1038/mt.2016.34
https://doi.org/10.1038/mt.2016.34
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 7, Iss C, Pp 83-95 (2017)
Molecular Therapy: Methods & Clinical Development, Vol 7, Iss C, Pp 83-95 (2017)
Mutations in the melanocortin-4-receptor (MC4R) comprise the most common monogenic form of severe early-onset obesity, and conventional treatments are either ineffective long-term or contraindicated. Immediately downstream of MC4R—in the pathway fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a74d6f794a9f05f224a960e44e87895d
https://pubmed.ncbi.nlm.nih.gov/29296625
https://pubmed.ncbi.nlm.nih.gov/29296625
Publikováno v:
Molecular Therapy. 22:1275-1284
Activation of the hypothalamus-adipocyte axis is associated with an antiobesity and anticancer phenotype in animal models of melanoma and colon cancer. Brain-derived neurotrophic factor (BDNF) is a key mediator in the hypothalamus leading to preferen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::225298823b49fe2723278487068660fb
https://doi.org/10.1038/mt.2014.45
https://doi.org/10.1038/mt.2014.45
Publikováno v:
Diabetes
Considering that impaired proximal insulin signaling is linked with diabetes, approaches that enhance glucose disposal independent of insulin signaling are attractive. In vitro data indicate that the E4ORF1 peptide derived from human adenovirus 36 (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90444e2fbbd5951a5b4df63dc871275f
https://pubmed.ncbi.nlm.nih.gov/27903748
https://pubmed.ncbi.nlm.nih.gov/27903748