Výsledky vyhledávání - "Travis M. LaVoi"

The Parallel Structure–Activity Relationship Screening of Three Compounds Identifies the Common Agonist Pharmacophore of Pyrrolidine Bis-Cyclic Guanidine Melanocortin-3 Receptor (MC3R) Small-Molecule Ligands

Autor: Haskell-Luevano, Mark D. Ericson, Katie T. Freeman, Travis M. LaVoi, Haley M. Donow, Radleigh G. Santos, Marc A. Giulianotti, Clemencia Pinilla, Richard A. Houghten, Carrie

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 12; Pages: 10145

The melanocortin receptors are involved in numerous physiological pathways, including appetite, skin and hair pigmentation, and steroidogenesis. In particular, the melanocortin-3 receptor (MC3R) is involved in fat storage, food intake, and energy hom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::76d440bd6940baadf6fdd1aa0c4404ab

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Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist

Autor: Courtney M Larson, Radleigh Santos, Richard A. Houghten, Mark D. Ericson, Katie T. Freeman, Zoe M. Koerperich, Rachel H Cho, Haley M. Donow, Clemencia Pinilla, Skye R. Doering, Travis M. Lavoi, Carrie Haskell-Luevano, Marc A. Giulianotti

Publikováno v: J Med Chem

The melanocortin-4 receptor (MC4R) plays an important role in appetite. Agonist ligands that stimulate the MC4R decrease appetite, while antagonist compounds increase food consumption. Herein, a functional mixture-based positional scan identified nov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d799fa35400e843e7186e1fca268b270
https://doi.org/10.1021/acs.jmedchem.1c01417

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Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput 'Unbiased' Screening Campaign

Autor: Phaedra Geer, Marc A. Giulianotti, Skye R. Doering, Travis M. Lavoi, Mark D. Ericson, Radleigh Santos, Katie T. Freeman, Carrie Haskell-Luevano, Richard A. Houghten, Jon R. Appel, Ginamarie Debevec, Clemencia Pinilla

Publikováno v: J Med Chem

The central melanocortin-3 and melanocortin-4 receptors (MC3R, MC4R) are key regulators of body weight and energy homeostasis. Herein, the discovery and characterization of first-in-class small molecule melanocortin agonists with selectivity for the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a9eb1c484c45bcbe6d841d2afad5501
https://doi.org/10.1021/acs.jmedchem.0c02041

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