Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Travis Linkous"'
Autor:
Liangliang Sun, Norman J. Dovichi, Ronald Schoner, Thomas Albanetti, Guijie Zhu, James B. McGivney, Travis Linkous, Christopher Larkin
Publikováno v:
Biotechnology and Bioengineering. 113:2140-2148
We employed UPLC-MS/MS with iTRAQ 8-plex labeling to quantitatively analyze the supernatant produced by two Chinese hamster ovary (CHO) cell lines (CHO K1SV and CHO CAT-S). In each case, the supernatant from the host and three transfected clones were
Autor:
Dawn Kernaghan, Guijie Zhu, James B. McGivney, Travis Linkous, Liangliang Sun, Norman J. Dovichi
Publikováno v:
ELECTROPHORESIS. 35:1448-1452
We report the first use of CZE for absolute characterization of host cell proteins (HCPs) in recombinant human monoclonal antibodies. An electrokinetically pumped nanoelectrospray interface was used to couple CZE with a tandem mass spectrometer. Thre
Autor:
Travis Linkous, Thomas Albanetti, Norman J. Dovichi, Ronald Schoner, James B. McGivney, Christopher Larkin, Zhenbin Zhang
Publikováno v:
Electrophoresis. 38(3-4)
Four methods were compared for analysis of host-cell protein (HCP) impurities in a recombinant mAb. First, CZE-MS/MS was used to analyze the digest of an HCP sample following extraction of the mAb with proteins A and L affinity columns; 220 protein g
Autor:
Guijie, Zhu, Liangliang, Sun, Thomas, Albanetti, Travis, Linkous, Christopher, Larkin, Ronald, Schoner, James B, McGivney, Norman J, Dovichi
Publikováno v:
Biotechnology and bioengineering. 113(10)
We employed UPLC-MS/MS with iTRAQ 8-plex labeling to quantitatively analyze the supernatant produced by two Chinese hamster ovary (CHO) cell lines (CHO K1SV and CHO CAT-S). In each case, the supernatant from the host and three transfected clones were
Autor:
Guijie, Zhu, Liangliang, Sun, Travis, Linkous, Dawn, Kernaghan, James B, McGivney, Norman J, Dovichi
Publikováno v:
Electrophoresis. 35(10)
We report the first use of CZE for absolute characterization of host cell proteins (HCPs) in recombinant human monoclonal antibodies. An electrokinetically pumped nanoelectrospray interface was used to couple CZE with a tandem mass spectrometer. Thre