Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Travis Lear"'
Autor:
Ferhan Tuncer, Melissa Bulik, John Villandre, Travis Lear, Yanwen Chen, Beyza Tuncer, Daniel J. Kass, Eleanor Valenzi, Christina Morse, John Sembrat, Robert Lafyatis, Bill Chen, John Evankovich
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 323(4)
Accumulation of excessive extracellular matrix (ECM) components from lung fibroblasts is a feature of systemic sclerosis-associated interstitial lung disease (SSc-ILD), and there is increasing evidence that innate immune signaling pathways contribute
Autor:
Michael M. Myerburg, Laura Salminen, Karina C. Lockwood, Bo Lin, Jie Liu, John Evankovich, Yuan Liu, Daniel P. Camarco, Yanwen Chen, Irene Alfaras, John F. McDyer, Bill B. Chen, Mads Breum Larsen, Toren Finkel, Travis Lear, Jason R. Kennerdell, Ferhan Tuncer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
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SARS-CoV-2 (2019-nCoV) is the pathogenic coronavirus responsible for the global pandemic of COVID-19 disease. The Spike (S) protein of SARS-CoV-2 attaches to host lung epithelial cells through the cell surface receptor ACE2, a process dependent on ho
Autor:
Travis Lear, Mads Larsen, Bo Lin, Qing Cao, Irene Alfaras, Jason Kennerdell, Laura Salminen, Daniel Camarco, Karina C. Lockwood, Áine Boudreau, Jing Ma, Jie Liu, Jay X. Tan, Michael M. Myerburg, Yanwen Chen, Claudette St Croix, Yusuke Sekine, John Evankovich, Toren Finkel, Bill B. Chen, Yuan Liu
Publikováno v:
The FASEB Journal. 36
Autor:
Bill B. Chen, Tiffany A. Coon, Jennifer R. Glasser, Chunbin Zou, Bryon Ellis, Tuhin Das, Alison C. McKelvey, Shristi Rajbhandari, Travis Lear, Christelle Kamga, Sruti Shiva, Chenjian Li, Joseph M. Pilewski, Jason Callio, Charleen T. Chu, Anuradha Ray, Prabir Ray, Yulia Y. Tyurina, Valerian E. Kagan, Rama K. Mallampalli
Publikováno v:
Cell Reports, Vol 7, Iss 2, Pp 476-487 (2014)
Summary: Acute lung injury (ALI) is linked to mitochondrial injury, resulting in impaired cellular oxygen utilization; however, it is unknown how these events are linked on the molecular level. Cardiolipin, a mitochondrial-specific lipid, is generate
Externí odkaz:
https://doaj.org/article/f58f4fba805b4b1fa45cbc1c553cb1b9
Autor:
Yu Jiang, Ferhan Tuncer, Brydie R. Huckestein, Yanwen Chen, Travis Lear, Jason R. Kennerdell, Yuan Liu, Matthew K. Nguyen, Satdarshan P.S. Monga, Rama K. Mallampalli, Toren Finkel, Bill B. Chen, Michael J. Jurczak, Bo Lin, Christopher P. O'Donnell, Mads Breum Larsen
Publikováno v:
Nature chemical biology
The adenosine monophosphate (AMP)-activated protein kinase (Ampk) is a central regulator of metabolic pathways, and increasing Ampk activity has been considered to be an attractive therapeutic target. Here, we have identified an orphan ubiquitin E3 l
Autor:
Michael J. Jurczak, Yuan Liu, Ferhan Tuncer, Tracy Tabib, John Evankovich, Christina Morse, Toren Finkel, Jason R. Kennerdell, Robert Lafyatis, Travis Lear, Bill B. Chen, Karina C. Lockwood, Mads Breum Larsen, Eleanor Valenzi, Daniel J. Kass
Publikováno v:
J Biol Chem
Systemic scleroderma (SSc) is an autoimmune disease that affects over 2.5 million people globally. SSc results in dysfunctional connective tissues with excessive profibrotic signaling, affecting skin, cardiovascular, and particularly lung tissue. Ove
Autor:
Rama K. Mallampalli, John Evankovich, Bill B. Chen, J. Villandre, Yuan Liu, Bryan J. McVerry, Travis Lear, Yanwen Chen, Virginia White, Courtney Baldwin, James D. Londino, Georgios D Kitsios
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 62:157-167
TLR8 (Toll-like receptor 8) is an intracellular pattern recognition receptor that senses RNA in endosomes to initiate innate immune signaling through NF-κB, and mechanisms regulating TLR8 protein abundance are not completely understood. Protein degr
Autor:
Travis Lear, Karina Lockwood, Áine Boudreau, Mads Larsen, Bo Lin, Stacey Sukoff-Rizzo, Yuan Liu, Toren Finkel, Bill Chen
Publikováno v:
Journal of Biological Chemistry. 299:104111
Publikováno v:
Journal of Immunology Research, Vol 2015 (2015)
Interleukin- (IL-) 22 signaling is protective in animal models of pneumonia and bacteremia by Klebsiella pneumoniae and mediates tissue recovery from influenza and Staph aureus infection. We recently described processing of mouse lung epithelial IL-2
Externí odkaz:
https://doaj.org/article/9d419a6a4f7f42dba73808025a766b83
Autor:
Y. Chen, Yuan Liu, Bill B. Chen, Ferhan Tuncer, J. Villandre, Travis Lear, John Evankovich, V. White, Daniel P. Camarco
Publikováno v:
TP113. TP113 ACUTE LUNG INJURY AND REPAIR.