Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Travis Law"'
Autor:
Marcela Maus, Rebecca Larson, Irene Scarfò, Max Jan, Stefanie Bailey, Amanda Bouffard, Michael Kann, Nicholas Haradhvala, Kai Stewart, Mark Leick, Trisha Berger, Julia Joung, Tamara Ouspenskaia, Travis Law, Aviv Regev, Gad Getz
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/92a54c122b9345659d7a4724b6e5bf0f
Autor:
Zongtai Qi, Yating Liu, Michael Mints, Riley Mullins, Reilly Sample, Travis Law, Thomas Barrett, Angela L. Mazul, Ryan S. Jackson, Stephen Y. Kang, Patrik Pipkorn, Anuraag S. Parikh, Itay Tirosh, Joseph Dougherty, Sidharth V. Puram
Publikováno v:
Cancers, Vol 13, Iss 6, p 1230 (2021)
Complexities in cell-type composition have rightfully led to skepticism and caution in the interpretation of bulk transcriptomic analyses. Recent studies have shown that deconvolution algorithms can be utilized to computationally estimate cell-type p
Externí odkaz:
https://doaj.org/article/4b0dbd53478f4e76951ac7e0942b4dd1
Autor:
Sidharth V. Puram, Michael Mints, Ananya Pal, Zongtai Qi, Ashley Reeb, Kyla Gelev, Thomas F. Barrett, Sophie Gerndt, Ping Liu, Anuraag S. Parikh, Salma Ramadan, Travis Law, Edmund A. Mroz, James W. Rocco, Doug Adkins, Wade L. Thorstad, Hiram A. Gay, Li Ding, Randal C. Paniello, Patrik Pipkorn, Ryan S. Jackson, Xiaowei Wang, Angela Mazul, Rebecca Chernock, Jose P. Zevallos, Jessica Silva-Fisher, Itay Tirosh
Publikováno v:
Nature Genetics. 55:640-650
Autor:
Michael Kann, Stefanie R. Bailey, Amanda A. Bouffard, Irene Scarfò, Max Jan, Julia Joung, Travis Law, Mark B. Leick, Gad Getz, Tamara Ouspenskaia, Rebecca C. Larson, Nicholas J. Haradhvala, Marcela V. Maus, Aviv Regev, Kai Stewart, Trisha R. Berger
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundChimeric Antigen Receptor (CAR) therapy has had a transformative impact on the treatment of hematologic malignancies1–6 but success in solid tumors remains elusive. We hypothesized solid tumors have cell-intrinsic resistance mechanisms to
Autor:
Rebecca C. Larson, Michael C. Kann, Stefanie R. Bailey, Nicholas J. Haradhvala, Paula Montero Llopis, Amanda A. Bouffard, Irene Scarfó, Mark B. Leick, Korneel Grauwet, Trisha R. Berger, Kai Stewart, Praju Vikas Anekal, Max Jan, Julia Joung, Andrea Schmidts, Tamara Ouspenskaia, Travis Law, Aviv Regev, Gad Getz, Marcela V. Maus
Publikováno v:
Nature. 604(7906)
Chimeric antigen receptor (CAR) therapy has had a transformative effect on the treatment of haematologic malignancies
Autor:
Rebecca Larson, Michael Kann, Stefanie Bailey, Nicholas Haradhvala, Kai Stewart, Amanda Bouffard, Irene Scarfo, Mark Leick, Trisha R Berger, Max Jan, Julia Joung, Tamara Ouspenskaia, Travis Law, Aviv Regev, Gad Getz, Marcela Maus
Publikováno v:
The Journal of Immunology. 208:176.18-176.18
Though CAR T cell therapy has had success treating hematologic malignancies, these treatments have shown only modest efficacy in solid tumors. Little is known about the necessary molecular components required for CAR T cell cytotoxicity, especially i
Autor:
Vinay K. Kartha, Lindsay M. LaFave, Alison Brack, Yan Hu, Ya-Chieh Hsu, Caleb A. Lareau, Travis Law, Jiarui Ding, Aviv Regev, Zachary Chiang, Sai Ma, Andrew S. Earl, Tristan Tay, Jason D. Buenrostro, Bing Zhang
Publikováno v:
Cell
PMC
PMC
© 2020 Elsevier Inc. Cell differentiation and function are regulated across multiple layers of gene regulation, including modulation of gene expression by changes in chromatin accessibility. However, differentiation is an asynchronous process preclu
Autor:
Lindsay M. LaFave, Travis Law, Yan Hu, Aviv Regev, Bing Zhang, Vinay K. Kartha, Sai Ma, Ya-Chieh Hsu, Zachary Chiang, Alison Brack, Jiarui Ding, Jason D. Buenrostro, Caleb A. Lareau
SummaryCell differentiation and function are regulated across multiple layers of gene regulation, including the modulation of gene expression by changes in chromatin accessibility. However, differentiation is an asynchronous process precluding a temp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b51c8faf7fd28a55a65905250eeb2d44
https://doi.org/10.1101/2020.06.17.156943
https://doi.org/10.1101/2020.06.17.156943
Autor:
Sachet A. Shukla, Wandi Zhang, Annie Apffel, Irwin Jungreis, Susan Klaeger, Aviv Regev, Bo Li, François Aguet, Zhe Ji, Tamara Ouspenskaia, Christina R. Hartigan, Nir Hacohen, Yuen Ting Chow, Catherine J. Wu, Gad Getz, Siranush Sarkizova, Travis Law, Phuong M. Le, Giacomo Oliveira, Steven A. Carr, Manolis Kellis, Derin B. Keskin, Karl R. Clauser, Hasmik Keshishian, Elena Christian, Binyamin A. Knisbacher, Pavan Bachireddy
Tumor epitopes – peptides that are presented on surface-bound MHC I proteins - provide targets for cancer immunotherapy and have been identified extensively in the annotated protein-coding regions of the genome. Motivated by the recent discovery of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d6ad79dd0b14c97faf6d14c6d58176
Autor:
Karl R. Clauser, Gad Getz, Wandi Zhang, Elena Christian, Siranush Sarkizova, Susan Klaeger, Bo Li, Yuen Ting Chow, Annie Apffel, Sune Justesen, Binyamin A. Knisbacher, François Aguet, Pavan Bachireddy, Catherine J. Wu, Aviv Regev, Christina R. Hartigan, Nir Hacohen, Sarah Chen, Irwin Jungreis, Zhe Ji, Hasmik Keshishian, Sachet A. Shukla, Phuong M. Le, Steven A. Carr, Tamara Ouspenskaia, Giacomo Oliveira, Travis Law, Manolis Kellis, Derin B. Keskin
Publikováno v:
Nature biotechnology. 40(2)
Tumor-associated epitopes presented on MHC-I that can activate the immune system against cancer cells are typically identified from annotated protein-coding regions of the genome, but whether peptides originating from novel or unannotated open readin