Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Travis L, Unger"'
Autor:
Maria E. Diaz-Ortiz, Yunji Seo, Marijan Posavi, Marc Carceles Cordon, Elisia Clark, Nimansha Jain, Rakshita Charan, Michael D. Gallagher, Travis L. Unger, Noor Amari, R. Tyler Skrinak, Roseanne Davila-Rivera, Eliza M. Brody, Noah Han, Rebecca Zack, Vivianna M. Van Deerlin, Thomas F. Tropea, Kelvin C. Luk, Edward B. Lee, Daniel Weintraub, Alice S. Chen-Plotkin
Publikováno v:
Science
Many risk loci for Parkinson’s disease (PD) have been identified by genome-wide association studies (GWASs), but target genes and mechanisms remain largely unknown. We linked the GWAS-derived chromosome 7 locus (sentinel single-nucleotide polymorph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d7d871b26bb08783f4c8c69708f4bf2
https://europepmc.org/articles/PMC9870036/
https://europepmc.org/articles/PMC9870036/
Autor:
Junchao Shen, Noor Amari, Rebecca Zack, R. Tyler Skrinak, Travis L. Unger, Marijan Posavi, Thomas F. Tropea, Sharon X. Xie, Vivianna M. Van Deerlin, Richard B. Dewey, Daniel Weintraub, John Q. Trojanowski, Alice S. Chen‐Plotkin
Publikováno v:
Annals of neurology. 92(2)
Using a multi-cohort, discovery-replication-validation design, we sought new plasma biomarkers that predict which individuals with Parkinson's disease (PD) will experience cognitive decline.In 108 discovery cohort PD individuals and 83 replication co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be3e1a3752fc33148674297c022911d
https://pubmed.ncbi.nlm.nih.gov/35593028
https://pubmed.ncbi.nlm.nih.gov/35593028
Autor:
Junchao Shen, Noor Amari, Rebecca Zack, R. Tyler Skrinak, Travis L. Unger, Marijan Posavi, Thomas F. Tropea, Sharon X. Xie, Vivianna M. Van Deerlin, Richard B. Dewey, Daniel Weintraub, John Q. Trojanowski, Alice S. Chen-Plotkin
ObjectiveUsing a multi-cohort, Discovery-Replication-Validation design, we sought new plasma biomarkers that predict which PD individuals will experience cognitive decline.MethodsIn 108 Discovery Cohort PD individuals and 83 Replication Cohort PD ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05d3b1a210dc220632a08d531548b994
https://doi.org/10.1101/2022.03.16.22272456
https://doi.org/10.1101/2022.03.16.22272456
Autor:
Lauren Elman, Edward B. Lee, Travis L. Unger, Defne A. Amado, John L. Robinson, John Q. Trojanowski, Vivianna M. Van Deerlin, Fei Mao, Virginia M.-Y. Lee, Alice Chen-Plotkin, Marijan Posavi, David A. Wolk, Murray Grossman, Sílvia Porta
Publikováno v:
Acta Neuropathol
The neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TAR DNA-binding protein-43 (TDP-43) inclusions (FTLD-TDP) share the neuropathological hallmark of aggregates of TDP-43. However, factors gov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d47ed414a746c385ba4d8d6261b9b960
https://europepmc.org/articles/PMC8812793/
https://europepmc.org/articles/PMC8812793/
Autor:
Defne A. Amado, Alice Chen-Plotkin, Yunji Seo, Rakshita A. Charan, Maria Diaz-Ortiz, Rebecca Zack, Travis L. Unger, Johanna I. Busch, Elisia M. Clark
Publikováno v:
SSRN Electronic Journal.
Frontotemporal lobar degeneration (FTLD) is a leading cause of early-onset dementia, but the pathological mechanisms underlying this disorder are not well understood. Common variants in the gene encoding Transmembrane Protein 106B (TMEM106B) increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08d30db17f321b94a22ee5d8d824bbf7
https://doi.org/10.2139/ssrn.3877559
https://doi.org/10.2139/ssrn.3877559
Autor:
Nancy M. Bonini, Sílvia Porta, Hyung-Jun Kim, Jason R. Kennerdell, Edwin R. Smith, Ali Shilatifard, Chia Yu Chung, Amit Berson, Vivianna M. Van Deerlin, Virginia M.-Y. Lee, Alice Chen-Plotkin, Ashley Sartoris, Travis L. Unger
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Nature Communications
TDP-43 is the major disease protein associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-TDP). Here we identify the transcriptional elongation factor Ell—a shared component of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e529b5c423080450758acb261d72d9b2
https://doi.org/10.1038/s41467-018-06543-0
https://doi.org/10.1038/s41467-018-06543-0
Autor:
Alessandra Chesi, Analise L. Gruenewald, Andrew D. Wells, Marijan Posavi, Peng Huang, Michael D. Gallagher, Alice Chen-Plotkin, Christopher D. Brown, Yosef Berlyand, Struan F.A. Grant, Elisabetta Manduchi, Gerd A. Blobel, Travis L. Unger
Neurodegenerative diseases pose an extraordinary threat to the world's aging population, yet no disease-modifying therapies are available. Although genome-wide association studies (GWASs) have identified hundreds of risk loci for neurodegeneration, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79f2139b9c48a00f2e6ea0005932de3a
https://europepmc.org/articles/PMC5673619/
https://europepmc.org/articles/PMC5673619/
Autor:
Ali Samii, John Q. Trojanowski, Christine R. Swanson, John W. Roberts, Rachel Goldmann Gross, Pinky Agarwal, Howard I. Hurtig, Kathy Li, Travis L. Unger, Daniel Weintraub, Michael D. Gallagher, Jacqueline Rick, Alice Chen-Plotkin, Cyrus P. Zabetian, Vivianna M. Van Deerlin, James B. Leverenz
Publikováno v:
Movement Disorders. 30:805-812
The discovery of novel plasma-based biomarkers could lead to new approaches in the treatment of Parkinson's disease (PD). Here, we explore the role of plasma apolipoprotein A1 (ApoA1) as a risk marker for PD and evaluate the influence of APOA1 promot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9968c5e290cb20aca740584f7194833
https://doi.org/10.1002/mds.26022
https://doi.org/10.1002/mds.26022
Autor:
Travis L. Unger, Virginia M.-Y. Lee, Alice Chen-Plotkin, Amit Berson, Edwin R. Smith, Chia Yu Chung, Sílvia Porta, Jason R. Kennerdell, Nancy M. Bonini, Hyung-Jun Kim, Ali Shilatifard, Vivianna M. Van Deerlin, Ashley Sartoris
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
The original version of this Article contained an error in the author affiliations. The affiliation of Alice Chen-Plotkin with the Department of Neurology, Perelman School of Medicine, Philadelphia, PA, 19104 USA was inadvertently omitted. This has n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::590ea0cb0adaa76922d73fb990acb294
https://doaj.org/article/047b45b259744e7ca73ab2b6088f0b28
https://doaj.org/article/047b45b259744e7ca73ab2b6088f0b28
Autor:
Sharon X. Xie, Ken Marek, John Q. Trojanowski, Andrew Siderowf, Christine R. Swanson, Travis L. Unger, Daniel Weintraub, Hua‐Ren Cherng, Matthew B. Stern, Alice Chen-Plotkin, Nicholas Lim
Publikováno v:
Annals of Clinical and Translational Neurology
Objective Cognitive decline occurs in multiple neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). Shared underlying mechanisms may exist and manifest as shared biomarker signatures. Previously, we nominated p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd68f74f2372410f5a468ccfe3ebafed
https://pubmed.ncbi.nlm.nih.gov/27231704
https://pubmed.ncbi.nlm.nih.gov/27231704