Human Fibrinogen for Maintenance and Differentiation of Induced Pluripotent Stem Cells in Two Dimensions and Three Dimensions

Autor: Jarel K. Gandhi, Travis Knudsen, Matthew Hill, Bhaskar Roy, Lori Bachman, Cynthia Pfannkoch‐Andrews, Karina N. Schmidt, Muriel M. Metko, Michael J. Ackerman, Zachary Resch, Jose S. Pulido, Alan D. Marmorstein

Publikováno v: Stem Cells Translational Medicine, Vol 8, Iss 6, Pp 512-521 (2019)

Abstract Human fibrin hydrogels are a popular choice for use as a biomaterial within tissue engineered constructs because they are biocompatible, nonxenogenic, autologous use compatible, and biodegradable. We have recently demonstrated the ability to

Externí odkaz: https://doaj.org/article/0535d765b7c9438eaddc30d6cf1f3e55

Small Molecules Restore Bestrophin 1 Expression and Function of Both Dominant and Recessive Bestrophinopathies in Patient-Derived Retinal Pigment Epithelium

Autor: Jingshu Liu, Forbes D C Manson, Travis Knudsen, Rachel L. Taylor, Richard A. Baines, Barbara Corneo, Graeme C.M. Black, Lisa Swanton, Sally Freeman, Alan D. Marmorstein, Achchhe Patel

Publikováno v: Liu, J, Taylor, R L, Baines, R, Swanton, E, Freeman, S, Corneo, B, Patel, A, Marmorstein, A, Knudson, T, Black, G & Manson, F 2020, ' Small Molecules Restore Bestrophin 1 Expression and Function of Both Dominant and Recessive Bestrophinopathies in Patient-Derived Retinal Pigment Epithelium. ', Investigative ophthalmology & visual science, vol. 61, no. 5, 28 . https://doi.org/10.1167/iovs.61.5.28
Investigative Ophthalmology & Visual Science

Purpose: Bestrophinopathies are a group of untreatable inherited retinal dystrophies caused by mutations in the retinal pigment epithelium (RPE) Cl− channel bestrophin 1. We tested whether sodium phenylbutyrate (4PBA) could rescue the function of m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b950c5aa451854fa595a51cdc09147
https://www.research.manchester.ac.uk/portal/en/publications/small-molecules-restore-bestrophin-1-expression-and-function-of-both-dominant-and-recessive-bestrophinopathies-in-patientderived-retinal-pigment-epithelium(5a73418e-ddcd-42c0-977d-aa37baa91aff).html

Mutant Best1 Expression and Impaired Phagocytosis in an iPSC Model of Autosomal Recessive Bestrophinopathy

Autor: Benjamin J. Gilles, Lihua Y. Marmorstein, Lori A. Bachman, Matthew Hill, Adiv A. Johnson, Jarel K. Gandhi, Cynthia Andrews-Pfannkoch, Travis Knudsen, Jose S. Pulido, Alan D. Marmorstein

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)

Autosomal recessive bestrophinopathy (ARB) is caused by mutations in the gene BEST1 which encodes bestrophin 1 (Best1), an anion channel expressed in retinal pigment epithelial (RPE) cells. It has been hypothesized that ARB represents the human null

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9ffd81b1d06a2b661e98356d9bad48
http://europepmc.org/articles/PMC5852082