Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Travis K, Worley"'
Autor:
Chettar A Hoff, Sierra S Schmidt, Brandy J Hackert, Travis K Worley, Justin Courcelle, Charmain T Courcelle
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 4 (2021)
AbstractUV irradiation induces pyrimidine dimers that block polymerases and disrupt the replisome. Restoring replication depends on the recF2222in vivo2222
Externí odkaz:
https://doaj.org/article/49c686a7b5fc4fc0ae38a711048c67f9
Autor:
Travis K Worley, Justin Courcelle, Charmain T. Courcelle, Chettar A. Hoff, Sierra S. Schmidt, Brandy J. Hackert
Publikováno v:
G3: Genes|Genomes|Genetics
G3: Genes, Genomes, Genetics, Vol 11, Iss 4 (2021)
G3: Genes, Genomes, Genetics, Vol 11, Iss 4 (2021)
UV irradiation induces pyrimidine dimers that block polymerases and disrupt the replisome. Restoring replication depends on the recF pathway proteins which process and maintain the replication fork DNA to allow the lesion to be repaired before replic
Publikováno v:
Genes. 13:437
Recombination mediator proteins have come into focus as promising targets for cancer therapy, with synthetic lethal approaches now clinically validated by the efficacy of PARP inhibitors in treating BRCA2 cancers and RECQ inhibitors in treating cance