Výsledky vyhledávání - "Travis J Jerde"

Akademický článek

Ras/ERK and PI3K/AKT signaling differentially regulate oncogenic ERG mediated transcription in prostate cells.

Autor: Brady G Strittmatter, Travis J Jerde, Peter C Hollenhorst

Publikováno v: PLoS Genetics, Vol 17, Iss 7, p e1009708 (2021)

The TMPRSS2/ERG gene rearrangement occurs in 50% of prostate tumors and results in expression of the transcription factor ERG, which is normally silent in prostate cells. ERG expression promotes prostate tumor formation and luminal epithelial cell fa

Externí odkaz: https://doaj.org/article/afec4a57568441b48b49b4d306cf744d

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Akademický článek

Inflammation impacts androgen receptor signaling in basal prostate stem cells through interleukin 1 receptor antagonist

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)

Abstract Chronic prostate inflammation in patients with benign prostate hyperplasia (BPH) correlates with the severity of symptoms. How inflammation contributes to prostate enlargement and/or BPH symptoms and the underlying mechanisms remain unclear.

Externí odkaz: https://doaj.org/article/be19327c8fd048d4a027b078790de3fc

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Supplementary Video 4 from Antitumor Activity and Mechanistic Characterization of APE1/Ref-1 Inhibitors in Bladder Cancer

Autor: Travis J. Jerde, Mark R. Kelley, Roberto Pili, Chi Zhang, George E. Sandusky, Hristos Z. Kaimakliotis, Ariel A. Craft, May Elbanna, David W. McIlwain, Jack McGeown, Hanyu Xia, Melissa L. Fishel

Video of caspase 3 activity used to capture images used in quantification of caspase activation, indicating apoptosis induction. Representative video of UC3 cells treated with APX2009 as red indicator dye generated from Caspase 3 activity is shown ov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc8ddb14f60f84d30976d7a7358b702
https://doi.org/10.1158/1535-7163.22506699

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Supplementary Figure 4 from Antitumor Activity and Mechanistic Characterization of APE1/Ref-1 Inhibitors in Bladder Cancer

Confirmation of APE1/Ref-1 and STAT3 expression in 3d and monolayer conditions in RP-B-O1 and RP-B-O2 cells. Basal growth conditions as described in the methods for each cell line were used for monolayer and 3D conditions. No significant differences

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b19cfe081f2cbc6cde32773bfe46106
https://doi.org/10.1158/1535-7163.22506711.v1

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Supplementary Video 1 from Antitumor Activity and Mechanistic Characterization of APE1/Ref-1 Inhibitors in Bladder Cancer

Video of caspase 3 activity used to capture images used in quantification of caspase activation, indicating apoptosis induction. Representative video of UC3 cells treated with DMSO control red dye by itself, Duration of the video is the 72 hour durat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b45c9239159680f687995d9f246c7d
https://doi.org/10.1158/1535-7163.22506708.v1

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Supplementary Video 3 from Antitumor Activity and Mechanistic Characterization of APE1/Ref-1 Inhibitors in Bladder Cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee42f76d7fd380b04bb3c78ba0297cd
https://doi.org/10.1158/1535-7163.22506702.v1

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Data from Antitumor Activity and Mechanistic Characterization of APE1/Ref-1 Inhibitors in Bladder Cancer

Bladder cancer is the ninth most common cause of cancer-related deaths worldwide. Although cisplatin is used routinely in treating bladder cancer, refractory disease remains lethal for many patients. The recent addition of immunotherapy has improved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbd2cdc8f258ebea1a8a8bc014271822
https://doi.org/10.1158/1535-7163.c.6538470.v1

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Supplementary Figure 2 from Antitumor Activity and Mechanistic Characterization of APE1/Ref-1 Inhibitors in Bladder Cancer

Structures and NMR analysis of novel ref-1 inhibitors APX2009 and APX2014. A. APX3330; NMR and HPLC as previously published.15-18 B. APX2009; HPLC: HPLC were performed using an Alltech Alltima column C18 5u, 250 x 5.6 mm, flow 1 mL/min at 40 .C. Elut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217c6ea1ee855423e4436642d3421944
https://doi.org/10.1158/1535-7163.22506717

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Supplementary Figure 3 from Antitumor Activity and Mechanistic Characterization of APE1/Ref-1 Inhibitors in Bladder Cancer

Confirmation of cell death induction by caspase activity assay and PARP cleavage. Representative images for caspase activity via red fluorescence [A] for the data calculated and shown in Figure 2, each with matching brightfield images. Representative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ba6586264b8ca68112e7d7f4aa4bb7
https://doi.org/10.1158/1535-7163.22506714

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