Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Travis Hughes"'
Mapping each pre-existing condition’s association to short-term and long-term COVID-19 complications
Autor:
A. J. Venkatakrishnan, Colin Pawlowski, David Zemmour, Travis Hughes, Akash Anand, Gabriela Berner, Nikhil Kayal, Arjun Puranik, Ian Conrad, Sairam Bade, Rakesh Barve, Purushottam Sinha, John C. O‘Horo, Andrew D. Badley, John Halamka, Venky Soundararajan
Publikováno v:
npj Digital Medicine, Vol 4, Iss 1, Pp 1-11 (2021)
Abstract Understanding the relationships between pre-existing conditions and complications of COVID-19 infection is critical to identifying which patients will develop severe disease. Here, we leverage ~1.1 million clinical notes from 1803 hospitaliz
Externí odkaz:
https://doaj.org/article/5d3be4022eee45a2a9e665e11457f771
Autor:
Yashaswi Shrestha, Michael Quigley, Travis Hughes, Robert T Manguso, Natalie B Collins, Rose Al Abosy, Brian C Miller, Kevin Bi, Qihong Zhao, Jeffrey J Ishizuka, Kathleen B Yates, Hans W Pope, Marc Wadsworth, Alex K Shalek, Jesse S Boehm, William C Hahn, John G Doench, W Nicholas Haining
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background Oncogenes act in a cell-intrinsic way to promote tumorigenesis. Whether oncogenes also have a cell-extrinsic effect on suppressing the immune response to cancer is less well understood.Methods We use an in vivo expression screen of known c
Externí odkaz:
https://doaj.org/article/2f18639e65804873a00ab93aef07c6bc
Autor:
Seul Kee Byeon, Anil K Madugundu, Kishore Garapati, Madan Gopal Ramarajan, Mayank Saraswat, Praveen Kumar-M, Travis Hughes, Rameen Shah, Mrinal M Patnaik, Nicholas Chia, Susan Ashrafzadeh-Kian, Joseph D Yao, Bobbi S Pritt, Roberto Cattaneo, Mohamed E Salama, Roman M Zenka, Benjamin R Kipp, Stefan K G Grebe, Ravinder J Singh, Amir A Sadighi Akha, Alicia Algeciras-Schimnich, Surendra Dasari, Janet E Olson, Jesse R Walsh, A J Venkatakrishnan, Garrett Jenkinson, John C O'Horo, Andrew D Badley, Akhilesh Pandey
Publikováno v:
The Lancet Digital Health. 4:e632-e645
COVID-19 is a multi-system disorder with high variability in clinical outcomes among patients who are admitted to hospital. Although some cytokines such as interleukin (IL)-6 are believed to be associated with severity, there are no early biomarkers
Autor:
David T. Severson, Samuel Freyaldenhoven, Benjamin Wadowski, Travis Hughes, Yin P. Hung, Roderick V. Jensen, William G. Richards, Corinne E. Gustafson, Kimberly Vermilya, Simona Innocenti, Julianne S. Barlow, Matthew B. Cougar, Jamie Anderson, Vivian Wang, Mary N. Dao, Alex K. Shalek, Assunta De Rienzo, Raphael Bueno
Publikováno v:
Cancer Research. 83:95-95
Pleural mesothelioma (PM) comprises three major histologic types: epithelioid, sarcomatoid, and a mixture of the two types termed biphasic. We and others have investigated whole transcriptome profiles of bulk PM samples, identifying a molecular gradi
Publikováno v:
Biophysical Journal. 122:467a
Autor:
Jacob M. Rosenberg, Joshua M. Peters, Travis Hughes, Caleb A. Lareau, Leif S. Ludwig, Lucas R. Massoth, Christina Austin-Tse, Heidi L. Rehm, Bryan Bryson, Yi-Bin Chen, Aviv Regev, Alex K. Shalek, Sarah M. Fortune, David B. Sykes
Publikováno v:
Med (N Y)
BACKGROUND: Idiopathic aplastic anemia is a potentially lethal disease, characterized by T-cell mediated autoimmune attack of bone marrow hematopoietic stem cells. Standard of care therapies (stem cell transplantation or immunosuppression) are effect
Autor:
Travis Hughes, Pritha Ghosh, David Zemmour, Venky Soundararajan, Praveen Anand, AJ Venkatakrishnan, Andrew P. Norgan, Bobbi S. Pritt, John C. O’Horo, Patrick Lenehan, Rohit Suratekar, Colin Pawlowski, Eli Silvert, Ryan T. Hurt, Joseph D. Yao, Andrew D. Badley, Michiel J.M. Niesen
Variants of SARS-CoV-2 are evolving under a combination of immune selective pressure in infected hosts and natural genetic drift, raising a global alarm regarding the durability of COVID-19 vaccines. Here, we conducted longitudinal analysis over 1.8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2bbf00ec663ea6ac06a7c4c74b92969
https://doi.org/10.1101/2021.07.01.21259833
https://doi.org/10.1101/2021.07.01.21259833
Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells
Autor:
Vivian Morris, Dahai Wang, Zhiheng Li, William Marion, Travis Hughes, Patricia Sousa, Taku Harada, Shannan Ho Sui, Sergey Naumenko, Jérémie Kalfon, Prerana Sensharma, Marcelo Falchetti, Renan Vinicius da Silva, Tito Candelli, Pauline Schneider, Thanasis Margaritis, Frank C.P. Holstege, Yana Pikman, Marian Harris, Ronald W. Stam, Stuart H. Orkin, Angela N. Koehler, Alex K. Shalek, Trista E. North, Maxim Pimkin, George Q. Daley, Edroaldo Lummertz da Rocha, R. Grant Rowe
Publikováno v:
Cell Reports. 39:110752
High-risk forms of B-acute lymphoblastic leukemia (B-ALL) remain a therapeutic challenge. Leukemia-initiating cells (LICs) self-renew and spark relapse and therefore have been the subject of intensive investigation; however, the properties of LICs in
Autor:
Juan Corchado-Garcia, David Puyraimond-Zemmour, Travis Hughes, Tudor Cristea-Platon, Patrick Lenehan, Colin Pawlowski, Sairam Bade, John C. O'Horo, Gregory J. Gores, Amy W. Williams, Andrew D. Badley, John Halamka, Abhinash Virk, Melanie D. Swift, Tyler Wagner, Venky Soundararajan
Publikováno v:
SSRN Electronic Journal.
In light of the massive and rapid vaccination campaign against COVID-19, continuous real-world effectiveness and safety assessment of the FDA-authorized vaccines is critical to amplify transparency, build public trust, and ultimately improve overall
Autor:
Karthik Murugadoss, Michiel Neisen, Bharathwaj Raghunathan, Patrick Lenehan, Pritha Ghosh, Tyler Feener, Praveen Anand, Safak Simsek, Rohit Suratekar, Travis Hughes, Venky Soundararajan
Publikováno v:
SSRN Electronic Journal.