Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Travis H Stracker"'
Autor:
Ilaria Dutto, Julian Gerhards, Antonio Herrera, Olga Souckova, Václava Škopová, Jordann A Smak, Alexandra Junza, Oscar Yanes, Cedric Boeckx, Martin D Burkhalter, Marie Zikánová, Sebastian Pons, Melanie Philipp, Jens Lüders, Travis H Stracker
Publikováno v:
eLife, Vol 11 (2022)
Adenylosuccinate lyase (ADSL) functions in de novo purine synthesis (DNPS) and the purine nucleotide cycle. ADSL deficiency (ADSLD) causes numerous neurodevelopmental pathologies, including microcephaly and autism spectrum disorder. ADSLD patients ha
Externí odkaz:
https://doaj.org/article/5ef7d8baa9df4de681a7f4e9f3e46c1a
Autor:
Josep Biayna, Isabel Garcia-Cao, Miguel M Álvarez, Marina Salvadores, Jose Espinosa-Carrasco, Marcel McCullough, Fran Supek, Travis H Stracker
Publikováno v:
PLoS Biology, Vol 19, Iss 3, p e3001176 (2021)
Analysis of cancer mutagenic signatures provides information about the origin of mutations and can inform the use of clinical therapies, including immunotherapy. In particular, APOBEC3A (A3A) has emerged as a major driver of mutagenesis in cancer cel
Externí odkaz:
https://doaj.org/article/cfacaccdda2642cca1c1b0906cd002bb
Autor:
Sergio Picart-Armada, Francesc Fernández-Albert, Maria Vinaixa, Miguel A Rodríguez, Suvi Aivio, Travis H Stracker, Oscar Yanes, Alexandre Perera-Lluna
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189012 (2017)
Metabolomics experiments identify metabolites whose abundance varies as the conditions under study change. Pathway enrichment tools help in the identification of key metabolic processes and in building a plausible biological explanation for these var
Externí odkaz:
https://doaj.org/article/a68891daab274ad9b76d99ae1e8c8b4d
Autor:
Travis H. Stracker
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
The transcription factor p53 (encoded by TP53) plays diverse roles in human development and disease. While best known for its role in tumor suppression, p53 signaling also influences mammalian development by triggering cell fate decisions in response
Externí odkaz:
https://doaj.org/article/5ab0839bac3443d6a41553376b235f08
Autor:
Wei-Ta Chen, Nancy D Ebelt, Travis H Stracker, Blerta Xhemalce, Carla L Van Den Berg, Kyle M Miller
Publikováno v:
eLife, Vol 4 (2015)
Ataxia-telangiectasia mutated (ATM) protein kinase regulates the DNA damage response (DDR) and is associated with cancer suppression. Here we report a cancer-promoting role for ATM. ATM depletion in metastatic cancer cells reduced cell migration and
Externí odkaz:
https://doaj.org/article/b022db6c1de84b82ba2b3a3238f5860f
De novo TLK1 and MDM1 mutations in a patient with a neurodevelopmental disorder and immunodeficiency
Autor:
Marina Villamor-Payà, María Sanchiz-Calvo, Jordann Smak, Lynn Pais, Malika Sud, Uma Shankavaram, Alysia Kern Lovgren, Christina Austin-Tse, Vijay S. Ganesh, Marina Gay, Marta Vilaseca, Gianluca Arauz-Garofalo, Lluís Palenzuela, Grace VanNoy, Anne O’Donnell-Luria, Travis H. Stracker
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109984- (2024)
Summary: The Tousled-like kinases 1 and 2 (TLK1/TLK2) regulate DNA replication, repair and chromatin maintenance. TLK2 variants underlie the neurodevelopmental disorder (NDD) ‘Intellectual Disability, Autosomal Dominant 57’ (MRD57), characterized
Externí odkaz:
https://doaj.org/article/9fee7cb1f61b4d7e99ce9dad37542610
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69986 (2013)
Centrosomes consist of two centrioles embedded in pericentriolar material and function as the main microtubule organising centres in dividing animal cells. They ensure proper formation and orientation of the mitotic spindle and are therefore essentia
Externí odkaz:
https://doaj.org/article/eab416abfe4b49d3ad2da419fadf17a2
Autor:
Michael Lewis, Berta Terré, Philip A. Knobel, Tao Cheng, Hao Lu, Camille Stephan-Otto Attolini, Jordann Smak, Etienne Coyaud, Isabel Garcia-Cao, Shalu Sharma, Chithran Vineethakumari, Jessica Querol, Gabriel Gil-Gómez, Gabriele Piergiovanni, Vincenzo Costanzo, Sandra Peiró, Brian Raught, Haotian Zhao, Xavier Salvatella, Sudipto Roy, Moe R. Mahjoub, Travis H. Stracker
Publikováno v:
Cell Death and Disease, Vol 14, Iss 3, Pp 1-15 (2023)
Abstract Multiciliated cells (MCCs) project dozens to hundreds of motile cilia from their apical surface to promote the movement of fluids or gametes in the mammalian brain, airway or reproductive organs. Differentiation of MCCs requires the sequenti
Externí odkaz:
https://doaj.org/article/6a20ac16e16e4c6f9816cfefaef6e20f
Autor:
Michael Lewis, Berta Terre, Philip A. Knobel, Tao Cheng, Hao Lu, Camille Stephan-Otto Attolini, Jordann Smak, Etienne Coyaud, Isabel Garcia-Cao, Jessica Querol, Gabriel Gil-Gomez, Gabrielle Piergiovanni, Vincenzo Costanzo, Sandra Peiró, Brian Raught, Haotian Zhao, Xavier Salvatella, Sudipto Roy, Moe Mahjoub, Travis H. Stracker
Multiciliated cells (MCCs) project dozens to hundreds of motile cilia from their apical surface to promote the movement of fluids or gametes in the mammalian brain, airway or reproductive organs. Differentiation of MCCs requires the sequential action
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bf9b756b31fd5a9ca85728ed239e5aa
https://doi.org/10.1101/2022.12.02.518887
https://doi.org/10.1101/2022.12.02.518887
Autor:
Travis H. Stracker
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 3 (2018)
In recent work we identified Exonuclease 3′−5′ domain-containing protein 2 (EXD2) as an RNase required for efficient mitochondrial translation. Here I describe in brief the cellular phenotypes caused by EXD2 deficiency and make the case that EX
Externí odkaz:
https://doaj.org/article/ed436a031ab24dc4b20b4f79d61da95d