Výsledky vyhledávání - "Travis B. Foland"

Differences in Paclitaxel and Docetaxel Interactions with Tubulin Detected by Mutagenesis of Yeast Tubulin

Autor: Richard H. Himes, Travis B. Foland, Ruth Entwistle, Gerald H. Lushington, Robert D. Winefield

Publikováno v: ChemMedChem. 3:1844-1847

Paclitaxel and a semi-synthetic analogue docetaxel (Scheme) are two taxane anti-tumor agents that are used against a number of cancers.[1] The taxanes bind to the β-subunit of the dimeric protein α,β-tubulin in microtubules in a 1:1 molar ratio, r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::195e0f6de24db4dfdc2f501a697ace51
https://doi.org/10.1002/cmdc.200800288

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Rap1p and other transcriptional regulators can function in defining distinct domains of gene expression

Autor: Travis B. Foland, Dan Griesen, Xin Bi, Qun Yu, Carl S. Galloway, Runxiang Qiu, Ya Hui Chiu, Joseph J. Sandmeier, James R. Broach

Publikováno v: Nucleic Acids Research. 31:1224-1233

Barrier elements that are able to block the propagation of transcriptional silencing in yeast are functionally similar to chromatin boundary/insulator elements in metazoans that delimit functional chromosomal domains. We show that the upstream activa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b08863712f9b975c75d0daf8a14df6e8
https://doi.org/10.1093/nar/gkg200

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The paclitaxel site in tubulin probed by site-directed mutagenesis of Saccharomyces cerevisiae β-tubulin

Autor: Robert D. Winefield, Richard H. Himes, Travis B. Foland, Gerald H. Lushington, Ruth Entwistle

Previously, we created a paclitaxel-sensitive strain of Saccharomyces cerevisiae by mutating five amino acid residues in beta-tubulin in a strain that has a decreased level of the ABC multidrug transporters. We have used site-directed mutagenesis to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa1bd3a6383e0306a82078d9fa8316e5
https://europepmc.org/articles/PMC2577837/

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Paclitaxel-induced microtubule stabilization causes mitotic block and apoptotic-like cell death in a paclitaxel-sensitive strain of Saccharomyces cerevisiae

Autor: Mohan L. Gupta, William L. Dentler, Travis B. Foland, Kathy A. Suprenant, Richard H. Himes

Wild-type Saccharomyces cerevisiae tubulin does not bind the anti-mitotic microtubule stabilizing agent paclitaxel. Previously, we introduced mutations into the S. cerevisiae gene for beta-tubulin that imparted paclitaxel binding to the protein, but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3415747e706fa5d3e765cf3f0c0fece
https://europepmc.org/articles/PMC3008355/

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