Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Travis B Thompson"'
Publikováno v:
Brain Multiphysics, Vol 6, Iss , Pp 100094- (2024)
Throughout the 19th and 20th centuries, aided by advances in medical imaging, discoveries in physiology and medicine have added nearly 25 years to the average life expectancy. This resounding success brings with it a need to understand a broad range
Externí odkaz:
https://doaj.org/article/22e4e2ebd5674032b5784d294cbe2891
This open access book bridges common tools in medical imaging and neuroscience with the numerical solution of brain modelling PDEs. The connection between these areas is established through the use of two existing tools, FreeSurfer and FEniCS, and on
Publikováno v:
Network Neuroscience, Vol 5, Iss 4, Pp 929-956 (2021)
AbstractA hallmark of Alzheimer’s disease is the aggregation of insoluble amyloid-beta plaques and tau protein neurofibrillary tangles. A key histopathological observation is that tau protein aggregates follow a structured progression pattern throu
Externí odkaz:
https://doaj.org/article/9260da5673794661a17e7a24c1b5462d
Publikováno v:
Brain Multiphysics, Vol 2, Iss , Pp 100039- (2021)
For more than 25 years, the amyloid hypothesis–the paradigm that amyloid is the primary cause of Alzheimer’s disease–has dominated the Alzheimer’s community. Now, increasing evidence suggests that tissue atrophy and cognitive decline in Alzhe
Externí odkaz:
https://doaj.org/article/d2b10433bdc54aa9a6e3dffb00c6bbb9
Autor:
Travis B Thompson, Pavanjit Chaggar, Ellen Kuhl, Alain Goriely, Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 10, p e1008267 (2020)
Neurodegenerative diseases such as Alzheimer's or Parkinson's are associated with the prion-like propagation and aggregation of toxic proteins. A long standing hypothesis that amyloid-beta drives Alzheimer's disease has proven the subject of contempo
Externí odkaz:
https://doaj.org/article/8603566a9dcf4b5b8809064f9a01ee55
Publikováno v:
SIAM Journal on Scientific Computing
The mechanical behavior of a poroelastic medium permeated by multiple interacting fluid networks can be described by a system of time-dependent partial differential equations known as the multiple-network poroelasticity (MPET) equations or multiporos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::772720eb36bb84fa365d799f59af0c60
https://doi.org/10.1137/20m1326751
https://doi.org/10.1137/20m1326751
Publikováno v:
Network Neuroscience, Vol 5, Iss 4, Pp 929-956 (2021)
Network Neuroscience
Network Neuroscience
A hallmark of Alzheimer’s disease is the aggregation of insoluble amyloid-beta plaques and tau protein neurofibrillary tangles. A key histopathological observation is that tau protein aggregates follow a structured progression pattern through the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1e20789ee1837e3fd1981e9a6ec2ddf
https://direct.mit.edu/netn/article/5/4/929/107175/Braiding-Braak-and-Braak-Staging-patterns-and
https://direct.mit.edu/netn/article/5/4/929/107175/Braiding-Braak-and-Braak-Staging-patterns-and
Publikováno v:
Numerical Methods for Partial Differential Equations. 36:1718-1734
When solving a multi-physics problem one often decomposes a monolithic system into simpler, frequently single-physics, subproblems. A comprehensive solution strategy may commonly be attempted, then, by means of combining strategies devised for the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::134add15eec51bf6375091e7b3420d58
https://doi.org/10.1002/num.22500
https://doi.org/10.1002/num.22500
Publikováno v:
Mathematical Modeling of the Human Brain ISBN: 9783030951351
The goal of this chapter is to outline how to perform a numerical simulation of a brain region defined from structural MR images. To address this challenge, we first demonstrate how to generate a high quality mesh of a brain hemisphere from T1-weight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6304739fca035456cdb56cea2c5971c
https://doi.org/10.1007/978-3-030-95136-8_3
https://doi.org/10.1007/978-3-030-95136-8_3
Publikováno v:
Mathematical Modeling of the Human Brain ISBN: 9783030951351
The human brain consists of multiple structures, including the large cerebrum, the smaller cerebellum, and the brain stem. These structures can easily be identified from MR images of the brain (Figure 2.1). The cerebrum is composed of the left and ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1f81d425c70731c67855d269034446f
https://doi.org/10.1007/978-3-030-95136-8_2
https://doi.org/10.1007/978-3-030-95136-8_2