Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Travis B Lear"'
Autor:
Alison C McKelvey, Travis B Lear, Sarah R Dunn, John Evankovich, James D Londino, Joseph S Bednash, Yingze Zhang, Bryan J McVerry, Yuan Liu, Bill B Chen
Publikováno v:
eLife, Vol 5 (2016)
Toll-like receptor 2 (TLR2) is a pattern recognition receptor that recognizes many types of PAMPs that originate from gram-positive bacteria. Here we describe a novel mechanism regulating TLR2 protein expression and subsequent cytokine release throug
Externí odkaz:
https://doaj.org/article/08233b1545cd43788cdf9e3ac9d8943a
Autor:
Yanwen Chen, Travis B. Lear, John W. Evankovich, Mads B. Larsen, Bo Lin, Irene Alfaras, Jason R. Kennerdell, Laura Salminen, Daniel P. Camarco, Karina C. Lockwood, Ferhan Tuncer, Jie Liu, Michael M. Myerburg, John F. McDyer, Yuan Liu, Toren Finkel, Bill B. Chen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The serine protease TMPRSS2 primes SARS-CoV-2 glycoprotein for cell entry. Here, the authors perform a screen to identify drugs that reduce TMPRSS2 expression and find that halofuginone modulates proteasome-mediated degradation of TMPRSS2 and reduces
Externí odkaz:
https://doaj.org/article/a96a0ab6494b4682a6b6f2fb49128893
Autor:
John Villandre, Virginia White, Travis B. Lear, Yanwen Chen, Ferhan Tuncer, Emily Vaiz, Beyza Tuncer, Karina Lockwood, Dan Camarco, Yuan Liu, Bill B. Chen, John Evankovich
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Aquaporin 5 (AQP5) is expressed in several cell types in the lung and regulates water transport, which contributes to barrier function during injury and the composition of glandular secretions. Reduced AQP5 expression is associated with barrier dysfu
Externí odkaz:
https://doaj.org/article/73aacb4825f14e54be2f65c7159d8b0b
Autor:
null Karina C. Lockwood, null Travis B. Lear, null Shristi Rajbhandari, null Alison C. McKelvey, null Sarah R. Dunn, null Áine N. Boudreau, null Yuan Liu, null Bill B. Chen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::429e375f460d226b22728ec6c56f47ba
https://doi.org/10.1111/febs.16780/v2/response1
https://doi.org/10.1111/febs.16780/v2/response1
Autor:
Travis B. Lear, Toren Finkel
Publikováno v:
The Journal of Cardiovascular Aging.
Senescent cell accumulation is increasingly associated with a number of age-related cardiovascular diseases. Now, a new manuscript in Nature Aging suggests that a novel vaccine-based strategy might provide a targeted method to eliminate the senescent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08e1f458af329a3ca754f7d968ee0094
https://doi.org/10.20517/jca.2022.03
https://doi.org/10.20517/jca.2022.03
Autor:
Yanwen Chen, John W. Evankovich, Travis B. Lear, Ferhan Tuncer, Jason R. Kennerdell, Daniel P. Camarco, Morgan S. Shishido, Yuan Liu, Bill B. Chen
Publikováno v:
Redox Biology, Vol 32, Iss , Pp - (2020)
NRF2 is a master regulator of cellular anti-oxidant and anti-inflammatory responses, and strategies to augment NRF2-dependent responses may beneficial in many diseases. Basal NRF2 protein level is constrained by constitutive KEAP1-mediated degradatio
Externí odkaz:
https://doaj.org/article/ef47379132804ee6bcd98013701659b9