PEG-PCL Nanocapsules Containing Curcumin: Validation of HPLC Method for Analyzing Drug-loading Efficiency, Stability Testing and Cytotoxicity on NIH-3T3 Cell Line

Autor: Loanda Aparecida Cabral Rudnik, Amanda Martinez Lyra, Fernanda Malaquias Barboza, Traudi Klein, Carla Cristine Kanunfre, Paulo Vitor Farago, Sandra Maria Warumby Zanin, Jessica Mendes Nadal

Publikováno v: Brazilian Archives of Biology and Technology, Vol 63 (2020)

Abstract Curcumin (CUR) shows potential use for treating cancer. However, CUR has low solubility and reduced bioavailability, which limit its clinical effect. Therefore, the development of nanocarriers can overcome these problems and can ensure the d

Externí odkaz: https://doaj.org/article/ca61fe5fec0f4b88a8d2b23262468aa4

Co-Loaded Curcumin and Methotrexate Nanocapsules Enhance Cytotoxicity against Non-Small-Cell Lung Cancer Cells

Autor: Loanda Aparecida Cabral Rudnik, Paulo Vitor Farago, Jane Manfron Budel, Amanda Lyra, Fernanda Malaquias Barboza, Traudi Klein, Carla Cristine Kanunfre, Jessica Mendes Nadal, Matheus Coelho Bandéca, Vijayasankar Raman, Andressa Novatski, Alessandro Dourado Loguércio, Sandra Maria Warumby Zanin

Publikováno v: Molecules, Vol 25, Iss 8, p 1913 (2020)

Background: As part of the efforts to find natural alternatives for cancer treatment and to overcome the barriers of cellular resistance to chemotherapeutic agents, polymeric nanocapsules containing curcumin and/or methotrexate were prepared by an in

Externí odkaz: https://doaj.org/article/1a56df8e712542689b743d0dc373de69

A simple HPLC method for the determination of halcinonide in lipid nanoparticles: development, validation, encapsulation efficiency, and in vitro drug permeation

Autor: Clarissa Elize Lopes, Gisele Langoski, Traudi Klein, Priscileila Colerato Ferrari, Paulo Vitor Farago

Publikováno v: Brazilian Journal of Pharmaceutical Sciences, Vol 53, Iss 2 (2017)

ABSTRACT Halcinonide is a high-potency topical glucocorticoid used for skin inflammation treatments that presents toxic systemic effects. A simple and quick analytical method to quantify the amount of halcinonide encapsulated into lipid nanoparticles

Externí odkaz: https://doaj.org/article/435ef1413bd24afd81d2220f35b8f65d

DEVELOPMENT AND VALIDATION OF AN RP-HPLC/UV METHOD FOR DETERMINATION OF CHOLECALCIFEROL IN POLYMERIC NANOPARTICLES SUSPENSIONS / DESENVOLVIMENTO E VALIDAÇÃO DE UM MÉTODO RP-HPLC/UV PARA DETERMINAÇÃO DO CHOLECALCIFEROL EM NANOPARTÍCULAS POLIMÉRICAS SUSPENSÕES

Autor: Barbara Justus, Traudi Klein, Ana Cristina Oltramari Toledo, Josiane Padilha de Paula, Luciane Stankiewski, Melissa Marques Gonçalves

Publikováno v: Brazilian Journal of Development. 7:17955-17967

A simple and effective RP-HPLC/UV method was developed to determine cholecalciferol (COL) in suspensions of polymeric nanoparticles. Chromatographic conditions used in the methodology were a C18 RP column using an isocratic mobile phase of methanol a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfd7deecc2c4232fefaeb07a38feef57
https://doi.org/10.34117/bjdv7n2-437

Paullinia cupana: a multipurpose plant – a review

Autor: João Carlos Palazzo de Mello, Mariana Nascimento de Paula, Traudi Klein, Leila Larisa Medeiros Marques, Emilene Dias Fiuza Ferreira

Publikováno v: Revista Brasileira de Farmacognosia, Vol 29, Iss 1, Pp 77-110 (2019)
Revista Brasileira de Farmacognosia, Volume: 29, Issue: 1, Pages: 110-77, Published: FEB 2019
Revista Brasileira de Farmacognosia v.29 n.1 2019
Revista Brasileira de Farmacognosia
Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA

Seeds of guarana (Paullinia cupana Kunth, Sapindaceae) feature diverse pharmacological functions, for example, antimicrobial, antioxidant, anticarcinogenic, stimulating, and cognitive functions, as well as liver protection and weight loss. Many of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcce485237c2edd8c99744d60cf1dca6
https://doi.org/10.1016/j.bjp.2018.08.007