Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Traude H. Beilharz"'
Autor:
Christopher McCrory, Jiyoti Verma, Timothy M. Tucey, Rachael Turner, Harshini Weerasinghe, Traude H. Beilharz, Ana Traven
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTMicrobes are exposed to nutritional and stress challenges in their environmental and host niches. To rise to these challenges, they regulate transcriptional programs that enable cellular adaptation. For instance, metabolite concentrations reg
Externí odkaz:
https://doaj.org/article/81b745c522a942899b1565bde7d0a50b
Autor:
C. Dilanka Fernando, W. Samantha N. Jayasekara, Chaitanya Inampudi, Maija R.J. Kohonen-Corish, Wendy A. Cooper, Traude H. Beilharz, Tracy M. Josephs, Daniel J. Garama, Daniel J. Gough
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113033- (2023)
Summary: Signal transducer and activator of transcription 3 (STAT3) is a potent transcription factor necessary for life whose activity is corrupted in diverse diseases, including cancer. STAT3 biology was presumed to be entirely dependent on its acti
Externí odkaz:
https://doaj.org/article/0b416294b8d648a2b18c0473e3703a04
Autor:
Jonathan W. Arthur, Hilda A. Pickett, Pasquale M. Barbaro, Tatjana Kilo, Raja S. Vasireddy, Traude H. Beilharz, David R. Powell, Emma L. Hackett, Bruce Bennetts, Julie A. Curtin, Kristi Jones, John Christodoulou, Roger R. Reddel, Juliana Teo, Tracy M. Bryan
Publikováno v:
eJHaem, Vol 2, Iss 2, Pp 157-166 (2021)
Abstract Telomere biology disorders (TBDs), including dyskeratosis congenita (DC), are a group of rare inherited diseases characterized by very short telomeres. Mutations in the components of the enzyme telomerase can lead to insufficient telomere ma
Externí odkaz:
https://doaj.org/article/36c1fe6971a84a47afc842d5b03c9c42
Autor:
Claudia Simm, Harshini Weerasinghe, David R. Thomas, Paul F. Harrison, Hayley J. Newton, Traude H. Beilharz, Ana Traven
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 2 (2022)
ABSTRACT Fungal infections are a global threat, but treatments are limited due to a paucity in antifungal drug targets and the emergence of drug-resistant fungi such as Candida auris. Metabolic adaptations enable microbial growth in nutrient-scarce h
Externí odkaz:
https://doaj.org/article/172355a0ddb54a15b437ef56414c2174
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Differential gene expression analysis may discover a set of genes too large to easily investigate, so a means of ranking genes by biological interest level is desired. p values are frequently abused for this purpose. As an alternative, we pr
Externí odkaz:
https://doaj.org/article/0e2c4690750f406da1a9d6450676e68f
Autor:
Qi Wang, Jiyoti Verma, Nikolina Vidan, Yanan Wang, Timothy M. Tucey, Tricia L. Lo, Paul F. Harrison, Michael See, Angavai Swaminathan, Karl Kuchler, Michael Tscherner, Jiangning Song, David R. Powell, Mary Sopta, Traude H. Beilharz, Ana Traven
Publikováno v:
Cell Reports, Vol 31, Iss 3, Pp - (2020)
Summary: Identification of multiple histone acylations diversifies transcriptional control by metabolism, but their functions are incompletely defined. Here we report evidence of histone crotonylation in the human fungal pathogen Candida albicans. We
Externí odkaz:
https://doaj.org/article/95f7d75aca524f688ecbafc907b55b71
Autor:
Luke E. Formosa, Linden Muellner-Wong, Boris Reljic, Alice J. Sharpe, Thomas D. Jackson, Traude H. Beilharz, Diana Stojanovski, Michael Lazarou, David A. Stroud, Michael T. Ryan
Publikováno v:
Cell Reports, Vol 31, Iss 3, Pp - (2020)
Summary: Mitochondrial complex I harbors 7 mitochondrial and 38 nuclear-encoded subunits. Its biogenesis requires the assembly and integration of distinct intermediate modules, mediated by numerous assembly factors. The mitochondrial complex I interm
Externí odkaz:
https://doaj.org/article/90e7c9bd26a2424f93f537aa0cd99268
Autor:
Rachael E. Turner, Traude H. Beilharz
Publikováno v:
Microorganisms, Vol 9, Iss 9, p 1885 (2021)
Alternative polyadenylation (APA) represents an important mechanism for regulating isoform-specific translation efficiency, stability, and localisation. Though some progress has been made in understanding its consequences in metazoans, the role of AP
Externí odkaz:
https://doaj.org/article/e9519a33b8d14d349a7ea3e7a0d4c027
Autor:
Jérémy Dufourt, Gwénaëlle Bontonou, Aymeric Chartier, Camille Jahan, Anne-Cécile Meunier, Stéphanie Pierson, Paul F. Harrison, Catherine Papin, Traude H. Beilharz, Martine Simonelig
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
In Drosophila embryos, Piwi-interacting RNAs (piRNAs) loaded into the PIWI protein Aubergine target and destabilize maternal mRNAs. Here, the authors provide evidence that piRNAs and Aubergine cooperate with the Wispy poly(A) polymerase to stabilize
Externí odkaz:
https://doaj.org/article/0c8ba84c5d204e5eb8d78432b292d38d
Autor:
Nitika Kandhari, Calvin A. Kraupner-Taylor, Paul F. Harrison, David R. Powell, Traude H. Beilharz
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10, p 5322 (2021)
Alternative transcript cleavage and polyadenylation is linked to cancer cell transformation, proliferation and outcome. This has led researchers to develop methods to detect and bioinformatically analyse alternative polyadenylation as potential cance
Externí odkaz:
https://doaj.org/article/52ba6bb572cf4f339123c235a15a147a