Diastereomers of Coibamide A Show Altered Sec61 Client Selectivity and Ligand-Dependent Activity against Patient-Derived Glioma Stem-like Cells.

Autor: Mattos DR; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, United States., Neves WD; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, United States., Kitamura T; Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan., Pradhan R; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, United States., Wan X; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, United States., da Hora CC; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, United States., Tranter D; Institute of Biotechnology, University of Helsinki, Helsinki 00014, Finland., Kazemi S; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, United States., Yu X; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, United States., Tripathy N; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, United States., Paavilainen VO; Institute of Biotechnology, University of Helsinki, Helsinki 00014, Finland., McPhail KL; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, United States., Oishi S; Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.; Laboratory of Medicinal Chemistry, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan., Badr CE; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, United States., Ishmael JE; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, United States.

Publikováno v: ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2024 May 14; Vol. 7 (6), pp. 1823-1838. Date of Electronic Publication: 2024 May 14 (Print Publication: 2024).

Signal peptide mimicry primes Sec61 for client-selective inhibition.

Autor: Rehan S; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland., Tranter D; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland., Sharp PP; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA., Craven GB; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA., Lowe E; Kezar Life Sciences, South San Francisco, CA, USA., Anderl JL; Kezar Life Sciences, South San Francisco, CA, USA., Muchamuel T; Kezar Life Sciences, South San Francisco, CA, USA., Abrishami V; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland., Kuivanen S; Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Wenzell NA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA., Jennings A; Kezar Life Sciences, South San Francisco, CA, USA., Kalyanaraman C; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of California, San Francisco, CA, USA., Strandin T; Department of Virology, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Javanainen M; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland., Vapalahti O; Department of Virology, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Jacobson MP; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of California, San Francisco, CA, USA., McMinn D; Kezar Life Sciences, South San Francisco, CA, USA., Kirk CJ; Kezar Life Sciences, South San Francisco, CA, USA., Huiskonen JT; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland., Taunton J; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA. jack.taunton@ucsf.edu., Paavilainen VO; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland. ville.paavilainen@helsinki.fi.

Publikováno v: Nature chemical biology [Nat Chem Biol] 2023 Sep; Vol. 19 (9), pp. 1054-1062. Date of Electronic Publication: 2023 May 11.

Snapshots of actin and tubulin folding inside the TRiC chaperonin.

Autor: Kelly JJ; Centre for Medicines Discovery, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Tranter D; Institute of Biotechnology, Helsinki Institute of Life Science HiLIFE, University of Helsinki, Helsinki, Finland., Pardon E; Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium.; VIB-VUB Center for Structural Biology, VIB, Brussels, Belgium., Chi G; Centre for Medicines Discovery, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Kramer H; Biological Mass Spectrometry and Proteomics Facility, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, London, UK., Happonen L; Division of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden., Knee KM; Pfizer Rare Disease Research Unit, Worldwide Research and Development, Pfizer Inc., Cambridge, MA, USA., Janz JM; Pfizer Rare Disease Research Unit, Worldwide Research and Development, Pfizer Inc., Cambridge, MA, USA., Steyaert J; Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium.; VIB-VUB Center for Structural Biology, VIB, Brussels, Belgium., Bulawa C; Pfizer Rare Disease Research Unit, Worldwide Research and Development, Pfizer Inc., Cambridge, MA, USA., Paavilainen VO; Institute of Biotechnology, Helsinki Institute of Life Science HiLIFE, University of Helsinki, Helsinki, Finland., Huiskonen JT; Institute of Biotechnology, Helsinki Institute of Life Science HiLIFE, University of Helsinki, Helsinki, Finland. juha.huiskonen@helsinki.fi.; Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland. juha.huiskonen@helsinki.fi.; Division of Structural Biology, Wellcome Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK. juha.huiskonen@helsinki.fi., Yue WW; Centre for Medicines Discovery, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK. wyatt.yue@cmd.ox.ac.uk.; Biosciences Institute, Medical School, Newcastle University, Newcastle upon Tyne, UK. wyatt.yue@cmd.ox.ac.uk.

Publikováno v: Nature structural & molecular biology [Nat Struct Mol Biol] 2022 May; Vol. 29 (5), pp. 420-429. Date of Electronic Publication: 2022 Apr 21.

The evolutionarily conserved PhLP3 is essential for sperm development in Drosophila melanogaster.

Autor: Petit, Christopher¹ (AUTHOR), Kojak, Elizabeth¹ (AUTHOR), Webster, Samantha¹ (AUTHOR), Marra, Michela² (AUTHOR), Sweeney, Brendan¹ (AUTHOR), Chaikin, Claire¹ (AUTHOR), Jemc, Jennifer C.^1,3 (AUTHOR) skanzok@luc.edu, Kanzok, Stefan M.^1,3 (AUTHOR) jmierisch@luc.edu

Publikováno v: PLoS ONE. 10/31/2024, Vol. 19 Issue 10, p1-27. 27p.

Kendomycin Cytotoxicity against Bacterial, Fungal, and Mammalian Cells Is Due to Cation Chelation.

Autor: Tranter D; Institute of Biotechnology, University of Helsinki, Helsinki, 00014, Finland., Filipuzzi I; Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland., Lochmann T; Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland., Knapp B; Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland., Kellosalo J; Institute of Biotechnology, University of Helsinki, Helsinki, 00014, Finland., Estoppey D; Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland., Pistorius D; Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland., Meissner A; Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland., Paavilainen VO; Institute of Biotechnology, University of Helsinki, Helsinki, 00014, Finland., Hoepfner D; Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland.

Publikováno v: Journal of natural products [J Nat Prod] 2020 Apr 24; Vol. 83 (4), pp. 965-971. Date of Electronic Publication: 2020 Mar 17.