Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Transmissible Spongiform Encephalopathy (TSE)"'
Publikováno v:
The Journal of Wildlife Management, 2006 Jan 01. 70(2), 546-553.
Externí odkaz:
https://www.jstor.org/stable/3803702
Autor:
Carlo Condello, Jacob I. Ayers, Clifton L. Dalgard, M. Madhy Garcia Garcia, Brianna M. Rivera, William W. Seeley, Daniel P. Perl, Stanley B. Prusiner
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 120, iss 13
The amyotrophic lateral sclerosis–parkinsonism dementia complex (ALS-PDC) of Guam is an endemic neurodegenerative disease that features widespread tau tangles, occasional α-synuclein Lewy bodies, and sparse β-amyloid (Aβ) plaques distributed in
Autor:
Alexander G. Murley, Yu Nie, Zoe Golder, Michael John Keogh, Colin Smith, James W. Ironside, Patrick F. Chinnery
Background and ObjectivesSporadic Creutzfeldt-Jakob disease (sCJD) has established genetic risk factors, but, in contrast to genetic and acquired CJD, the initial trigger for misfolded prion aggregation and spread is not known. In this study, we test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c2bf1b04c25682b557a16d276dec55
https://www.repository.cam.ac.uk/handle/1810/343417
https://www.repository.cam.ac.uk/handle/1810/343417
Autor:
Paoletti, Matteo, Caverzasi, Eduardo, Mandelli, Maria Luisa, Brown, Jesse A, Henry, Roland G, Miller, Bruce L, Rosen, Howard J, DeArmond, Stephen J, Bastianello, Stefano, Seeley, William W, Geschwind, Michael D
Publikováno v:
Human brain mapping, vol 43, iss 13
Grey matter involvement is a well-known feature in sporadic Creutzfeldt-Jakob disease (sCJD), yet precise anatomy-based quantification of reduced diffusivity is still not fully understood. Default Mode Network (DMN) areas have been recently demonstra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::47acc814e67200d0cf9307acd5ac7745
https://escholarship.org/uc/item/8qc4f562
https://escholarship.org/uc/item/8qc4f562
Autor:
Jacob I. Ayers, Joanne Lee, Octovia Monteiro, Amanda L. Woerman, Ann A. Lazar, Carlo Condello, Nick A. Paras, Stanley B. Prusiner
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 6
The α-synuclein protein can adopt several different conformations that cause neurodegeneration. Different α-synuclein conformers cause at least three distinct α-synucleinopathies: multiple system atrophy (MSA), dementia with Lewy bodies (DLB), and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70bd2ca964e1d1e834337731eefd1393
https://escholarship.org/uc/item/3cf4v001
https://escholarship.org/uc/item/3cf4v001
Autor:
M. Jake Pushie, Glenn L. Millhauser, David A. Harris, Natalia C. Ubilla-Rodriguez, R. David Britt, Joseph T. M. Kiblen, Kevin M. Schilling, Bei Wu, Graham Roseman, Lizhi Tao
Publikováno v:
Journal of molecular biology, vol 432, iss 16
J Mol Biol
J Mol Biol
The cellular prion protein (PrP(C)) is comprised of two domains – a globular C-terminal domain and an unstructured N-terminal domain. Recently, copper has been observed to drive tertiary contact in PrP(C), inducing a neuroprotective cis interaction
Publikováno v:
Nature structural & molecular biology
Nature structural & molecular biology, vol 27, iss 6
Nature structural & molecular biology, vol 27, iss 6
Amyloid appearance is a rare event that is promoted in the presence of other aggregated proteins. These aggregates were thought to act by templating the formation of an assembly-competent nucleation seed, but we find an unanticipated role for them in
Autor:
Hermann C. Altmeppen, Christina J. Sigurdson, Timothy D. Kurt, Donald P. Pizzo, Sofie Nyström, Thu H Nam, Katrin Soldau, Jeffrey D. Esko, K. Peter R. Nilsson, Taylor Schumann, Jessica Lawrence, Markus Glatzel, Patricia Aguilar-Calvo, Biswa Choudhury, Alejandro M. Sevillano
Publikováno v:
J Clin Invest
The Journal of clinical investigation, vol 130, iss 3
The Journal of clinical investigation, vol 130, iss 3
Posttranslational modifications (PTMs) are common among proteins that aggregate in neurodegenerative disease, yet how PTMs impact the aggregate conformation and disease progression remains unclear. By engineering knockin mice expressing prion protein
Autor:
Amy V. Nalls, Erin E. McNulty, Amber Mayfield, James M. Crum, Michael K. Keel, Edward A. Hoover, Mark G. Ruder, Candace K. Mathiason
Publikováno v:
Viruses
Viruses, vol 13, iss 12
Viruses; Volume 13; Issue 12; Pages: 2430
Viruses, Vol 13, Iss 2430, p 2430 (2021)
Viruses, vol 13, iss 12
Viruses; Volume 13; Issue 12; Pages: 2430
Viruses, Vol 13, Iss 2430, p 2430 (2021)
The transmission of chronic wasting disease (CWD) has largely been attributed to contact with infectious prions shed in excretions (saliva, urine, feces, blood) by direct animal-to-animal exposure or indirect contact with the environment. Less-well s
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