Zobrazeno 1 - 10
of 3 569
pro vyhledávání: '"Translocon"'
Autor:
Laura M Chamness, Charles P Kuntz, Andrew G McKee, Wesley D Penn, Christopher M Hemmerich, Douglas B Rusch, Hope Woods, Dyotima, Jens Meiler, Jonathan P Schlebach
Publikováno v:
eLife, Vol 12 (2024)
Many membrane proteins are prone to misfolding, which compromises their functional expression at the plasma membrane. This is particularly true for the mammalian gonadotropin-releasing hormone receptor GPCRs (GnRHR). We recently demonstrated that evo
Externí odkaz:
https://doaj.org/article/87e6dc4267994ade8aebd09e14ada9b5
Publikováno v:
eLife, Vol 13 (2024)
The protein translocon at the endoplasmic reticulum comprises the Sec61 translocation channel and numerous accessory factors that collectively facilitate the biogenesis of secretory and membrane proteins. Here, we leveraged recent advances in cryo-el
Externí odkaz:
https://doaj.org/article/4407370f45984775adebe84f06d6491f
Autor:
Dimitrios Vismpas, Friedrich Förster
Publikováno v:
eLife, Vol 13 (2024)
Advanced cryo-EM approaches reveal surprising insights into the molecular structure that allows nascent proteins to be inserted into the membrane of the endoplasmic reticulum.
Externí odkaz:
https://doaj.org/article/03de1a0db44a44c281fd3e6bd286b81c
Characterization of translocon proteins in the type III secretion system of Lawsonia intracellularis
Autor:
Beibei Huang, Zihe Zhu, Yimin Dai, Chengxian Yan, Jingyu Xu, Lingling Sun, Qinghua Zhang, Xuejiao An, Fenju Lai
Publikováno v:
Veterinary Research, Vol 54, Iss 1, Pp 1-15 (2023)
Abstract Lawsonia intracellularis, the etiologic agent of proliferative enteropathy (PE), is an obligate intracellular Gram-negative bacterium possessing a type III secretion system (T3SS), which enables the pathogen to translocate effector proteins
Externí odkaz:
https://doaj.org/article/610e0d8b03dc4e559cdc2076afc44150
Autor:
Ashuei Sogawa, Ryota Komori, Kota Yanagitani, Miku Ohfurudono, Akio Tsuru, Koji Kadoi, Yukio Kimata, Hiderou Yoshida, Kenji Kohno
Publikováno v:
Cell Structure and Function, Vol 48, Iss 2, Pp 211-221 (2023)
Secretory pathway proteins are cotranslationally translocated into the endoplasmic reticulum (ER) of metazoan cells through the protein channel, translocon. Given that there are far fewer translocons than ribosomes in a cell, it is essential that sec
Externí odkaz:
https://doaj.org/article/cad2245e20b043869e0ac315ead82998
Autor:
Hilal Yeter-Alat, Naïma Belgareh-Touzé, Agnès Le Saux, Emmeline Huvelle, Molka Mokdadi, Josette Banroques, N. Kyle Tanner
Publikováno v:
Molecules, Vol 29, Iss 12, p 2944 (2024)
The DEAD-box RNA helicase Ded1 is an essential yeast protein involved in translation initiation that belongs to the DDX3 subfamily. The purified Ded1 protein is an ATP-dependent RNA-binding protein and an RNA-dependent ATPase, but it was previously f
Externí odkaz:
https://doaj.org/article/39bf31f6e85d49b399b6110509da1389
Autor:
Salah I. Farag, Monika K. Francis, Jyoti M. Gurung, Sun Nyunt Wai, Hans Stenlund, Matthew S. Francis, Aftab Nadeem
Publikováno v:
Virulence, Vol 14, Iss 1 (2023)
ABSTRACTTranslocon pores formed in the eukaryotic cell membrane by a type III secretion system facilitate the translocation of immune-modulatory effector proteins into the host cell interior. The YopB and YopD proteins produced and secreted by pathog
Externí odkaz:
https://doaj.org/article/70eca4bb7a0c4ec9a968ede713155bf1
Akademický článek
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Autor:
Adolfo Cavalié, Richard Zimmermann
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/b66270014ec54cc8abb496426ded76ca
Publikováno v:
Toxins, Vol 15, Iss 8, p 486 (2023)
Mycolactone is an exotoxin produced by Mycobacterium ulcerans that causes the neglected tropical skin disease Buruli ulcer. This toxin inhibits the Sec61 translocon in the endoplasmic reticulum (ER), preventing the host cell from producing several se
Externí odkaz:
https://doaj.org/article/10d4da25abf74954a193e0545b81f5eb