Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Translational toxicology"'
Autor:
Rebekah L. Petroff, Dana C. Dolinoy, Kai Wang, Luke Montrose, Vasantha Padmanabhan, Karen E. Peterson, Douglas M. Ruden, Maureen A. Sartor, Laurie K. Svoboda, Martha M. Téllez-Rojo, Jaclyn M. Goodrich
Publikováno v:
Environment International, Vol 186, Iss , Pp 108575- (2024)
Although toxicology uses animal models to represent real-world human health scenarios, a critical translational gap between laboratory-based studies and epidemiology remains. In this study, we aimed to understand the toxicoepigenetic effects on DNA m
Externí odkaz:
https://doaj.org/article/250e66bb854f46d58bad6a02891c8046
Akademický článek
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Akademický článek
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Akademický článek
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Autor:
Kayla L Frost, Joseph L Jilek, Austin D Thompson, Robert R Klein, Shripad Sinari, Elmira Torabzedehkorasani, Dean D Billheimer, Rick G Schnellmann, Nathan J Cherrington
Publikováno v:
Toxicol Sci
Inflammatory liver diseases, including nonalcoholic steatohepatitis (NASH), alcohol-associated liver disease (ALD), hepatitis C virus (HCV), and ALD/HCV, account for nearly 2 million deaths annually. Despite increasing evidence that liver dysfunction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b74113f6fce35f087ee353acd0c21e1e
https://doi.org/10.1093/toxsci/kfac070
https://doi.org/10.1093/toxsci/kfac070
Autor:
Brian Buckley, Keith R. Cooper, Kristin R Terez, Jordan M. Hotz, Leonor Côrte-Real, Victoria L. DiBona, Andreia Valente, Brittany F Karas, Brian M Gural
Publikováno v:
Toxicol Sci
Ruthenium is popular as a metal core for chemotherapeutics, due to versatile molecular coordination. Because new metallodrugs are synthesized at high rates, our studies included assays in zebrafish to expedite the initial evaluation as anticancer age
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eedbfdff8f506488205a9fe690758ab
https://doi.org/10.1093/toxsci/kfab041
https://doi.org/10.1093/toxsci/kfab041
Autor:
Michael C. Boyle, Rocio Hernandez, Brendon Frank, Qinghong Yan, Chi-Ming Li, Herve Lebrec, Tara Arvedson, Oliver Homann, Xiaoting Wang, Rebecca Goldstein, K.H. Kim, Benjamin Brooks, Christine M. Karbowski, Gregor Adams, Kelly Hensley
Publikováno v:
Toxicological Sciences
Feline McDonough Sarcoma-like tyrosine kinase 3 (FLT3), a tyrosine-protein kinase involved in hematopoiesis, is detectable on the cell surface of approximately 80% of leukemia isolates from adult patients with acute myeloid leukemia (AML). AMG 553 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bccf5d203ae6e3cb166793e27eeb086e
https://doi.org/10.1093/toxsci/kfaa098
https://doi.org/10.1093/toxsci/kfaa098
Autor:
Merrie Mosedale, Paul B. Watkins, William Valdar, Robert W. Corty, John S. Eaddy, Manisha Nautiyal, Yanwei Cai
Publikováno v:
Toxicol Sci
Idelalisib is a phosphatidylinositol 3-kinase inhibitor highly selective for the delta isoform that has shown good efficacy in treating chronic lymphocytic leukemia and follicular lymphoma. In clinical trials, however, idelalisib was associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75641aa8795e2bcf87e4c36a4d893d46
https://doi.org/10.1093/toxsci/kfz199
https://doi.org/10.1093/toxsci/kfz199
Autor:
Mechelle M. Lewis, Gregory L. Brown, Elizabeth B. Neely, Leslie C Jellen, Guangwei Du, Ernest W. Wang, James R. Connor, Hairong Chen, Max L Trojano, Lan Kong, Insung Song, Xuemei Huang
Publikováno v:
Toxicol Sci
Paraquat is an herbicide whose use is associated with Parkinson’s disease (PD), a neurodegenerative disorder marked by neuron loss in the substantia nigra pars compacta (SNc). We recently observed that the murine homolog to the human H63D variant o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1acb1c08ba21ada96642372fd818028d
https://pubmed.ncbi.nlm.nih.gov/33739421
https://pubmed.ncbi.nlm.nih.gov/33739421
Autor:
Jian Hua Li, Xiaochao Ma, Amina I. Shehu, Deborah McMahon, Frank J. Gonzalez, Junjie Zhu, Wen Xie, Jie Lu
Publikováno v:
Toxicol Sci
Liver-related diseases including drug-induced liver injury are becoming increasingly prominent in AIDS patients. Cobicistat (COBI) is the backbone of multiple regimens for antiretroviral therapy. The current work investigated the mechanisms of advers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a66fe3ce3a39ea25d303eb83f79ebb
https://europepmc.org/articles/PMC8081023/
https://europepmc.org/articles/PMC8081023/
