Zobrazeno 1 - 10
of 872
pro vyhledávání: '"Transgenic mouse models"'
Autor:
Juan Antonio López-Villodres, Alejandro Escamilla, Silvia Mercado-Sáenz, Carmen Alba-Tercedor, Luis Manuel Rodriguez-Perez, Isabel Arranz-Salas, Raquel Sanchez-Varo, Diego Bermúdez
Publikováno v:
Biomedicines, Vol 11, Iss 7, p 1846 (2023)
In the last decade, the role of the microbiota–gut–brain axis has been gaining momentum in the context of many neurodegenerative and metabolic disorders, including Alzheimer’s disease (AD) and diabetes, respectively. Notably, a balanced gut mic
Externí odkaz:
https://doaj.org/article/e261c51907204380ad8513d243dfb87c
Publikováno v:
Brain and Behavior, Vol 12, Iss 7, Pp n/a-n/a (2022)
Abstract Background Intracellular deposition of alpha‐synuclein (α‐syn) as Lewy bodies and Lewy neurites is a central event in the pathogenesis of Parkinson's disease (PD) and other α‐synucleinopathies. Transgenic mouse models overexpressing
Externí odkaz:
https://doaj.org/article/a606ebf0f1954c5a8d104cce47e36bc1
Autor:
Chi Him Poon, San Tung Nicholas Wong, Jaydeep Roy, Yingyi Wang, Hui Wang Hujo Chan, Harry Steinbusch, Arjan Blokland, Yasin Temel, Luca Aquili, Lee Wei Lim
Publikováno v:
Cells, Vol 12, Iss 5, p 780 (2023)
A promising direction in the research on Alzheimer’s Disease (AD) is the identification of biomarkers that better inform the disease progression of AD. However, the performance of amyloid-based biomarkers in predicting cognitive performance has bee
Externí odkaz:
https://doaj.org/article/731256b8069a41efb29d53e3383b3758
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6331 (2023)
Regulatory T cells (Treg) are essential for the maintenance of peripheral tolerance. Treg dysfunction results in diverse inflammatory and autoimmune diseases with life-threatening consequences. β2-integrins (CD11a-d/CD18) play important roles in the
Externí odkaz:
https://doaj.org/article/964ed81a7474420ea77b4f2ae590b0b9
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Aging is the main risk factor for sporadic Alzheimer’s disease (AD), which is characterized by the cerebral deposition of β-amyloid peptides (Aβ) and cognitive decline. Mitochondrial dysfunction is also characteristic of the disease and represent
Externí odkaz:
https://doaj.org/article/83830320b96c496099e1057b85a44880
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal bone-marrow diseases with ineffective hematopoiesis resulting in cytopenias and morphologic dysplasia of hematopoietic cells. MDS carry a wide spectrum of genetic abnormalities, rang
Externí odkaz:
https://doaj.org/article/fb326ed236504478b4cc24d7e74cfc51
Autor:
Mengfei Xiong, Sahar Roshanbin, Johanna Rokka, Eva Schlein, Martin Ingelsson, Dag Sehlin, Jonas Eriksson, Stina Syvänen
Publikováno v:
NeuroImage, Vol 239, Iss , Pp 118302- (2021)
The positron emission tomography (PET) radioligand [11C]UCB-J binds to synaptic vesicle protein 2A (SV2A) and is used to investigate synaptic density in the living brain. Clinical studies have indicated reduced [11C]UCB-J binding in Alzheimer's disea
Externí odkaz:
https://doaj.org/article/10ec8ff4089b4ac3a605860de74a7afc
Autor:
Claudia Green, Astrid Sydow, Stefanie Vogel, Marta Anglada-Huguet, Dirk Wiedermann, Eckhard Mandelkow, Eva-Maria Mandelkow, Mathias Hoehn
Publikováno v:
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-13 (2019)
Abstract Background Aggregation of tau proteins is a distinct hallmark of tauopathies and has been a focus of research and clinical trials for Alzheimer’s Disease. Recent reports have pointed towards a toxic effect of soluble or oligomeric tau in t
Externí odkaz:
https://doaj.org/article/b4dfec4265824357ac8bceee89b61f95
Autor:
Thomas Leyhe, Mathias Jucker, Tobias Nef, Marc Sollberger, Florian Riese, José Haba-Rubio, Henk Verloo, Regula Lüthi, Stefanie Becker, Julius Popp
Publikováno v:
Swiss Medical Weekly, Vol 150, Iss 4950 (2020)
In October 2019, a Swiss panel of experts met for the Dementia Summit in Brunnen, Switzerland, to discuss the latest scientific findings on basic and clinical research, as well as practical and political approaches to the challenges of dementia disor
Externí odkaz:
https://doaj.org/article/e604c5901d70486391ee92ad742dbe18
Mouse Models of c-myc Deregulation Driven by IgH Locus Enhancers as Models of B-Cell Lymphomagenesis
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Chromosomal translocations linking various oncogenes to transcriptional enhancers of the immunoglobulin heavy chain (IgH) locus are often implicated as the cause of B-cell malignancies. Two major IgH transcriptional enhancers have been reported so fa
Externí odkaz:
https://doaj.org/article/aac81d943aea4a68b0ed166f0f13f2e1