Zobrazeno 1 - 10
of 15 602
pro vyhledávání: '"Transgenic mouse"'
Autor:
Yu C. J. Chey, Mark A. Corbett, Jayshen Arudkumar, Sandra G. Piltz, Paul Q. Thomas, Fatwa Adikusuma
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background The development of sequence-specific precision treatments like CRISPR gene editing therapies for Duchenne muscular dystrophy (DMD) requires sequence humanized animal models to enable the direct clinical translation of tested strat
Externí odkaz:
https://doaj.org/article/dcea31a8dfee493680c161e9f4f7c5c9
Autor:
Muhammad Ashfaq Khan, Julian Fischer, Leon Harrer, Fabian Schwiering, Dieter Groneberg, Andreas Friebe
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract The combination of lineage tracing and immunohistochemistry has helped to identify subpopulations and fate of hepatic stellate cells (HSC) in murine liver. HSC are sinusoidal pericytes that act as myofibroblast precursors after liver injury.
Externí odkaz:
https://doaj.org/article/091f823e807f4d8987d870c715dd14b5
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract The in vivo functions of SerpinB2 in tumor cells and tumor-associated macrophages (TAMs) during breast cancer development and metastasis remain elusive. SerpinB2-deficient MMTV-PyMT mice (PyMTSB2−/−) were previously produced to explore t
Externí odkaz:
https://doaj.org/article/276a1b403e454f82b057889992ed0ec1
Autor:
Song Luo, Xiaorui Wang, Bo Ma, Dongliang Liu, Li Li, Lijin Wang, Ning Ding, Liangyu Zou, Jie Wang, Jialin Pan, Daoqian Sang, Huadong Zhou, Hongdang Qu, Yi Lu, Lijuan Yang
Publikováno v:
Biomolecules & Biomedicine (2024)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the selective death of motor neurons in the spinal cord, brainstem, and motor cortex. This study investigates the effects of simvastatin on the G93A-copper/zinc super
Externí odkaz:
https://doaj.org/article/e65bcf1bf9f54400a645f70da5ade889
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/c08e32296ff7429db40cffbe001dffb9
Autor:
Ricardo Magalhães, Fernanda Marques, Erwan Selingue, Fawzi Boumezbeur, Sébastien Mériaux, Nuno Sousa
Publikováno v:
Neurobiology of Disease, Vol 201, Iss , Pp 106679- (2024)
Alzheimer's disease (AD) is characterized by progressive cognitive decline and neuropathological changes, yet the underlying neurobiological mechanisms remain elusive. Here, we employed a multimodal longitudinal neuroimaging approach, using anatomica
Externí odkaz:
https://doaj.org/article/11fe630ab41f460f9ebf21b211cde3bd
Autor:
Estelle Schueller, Iris Grgurina, Brigitte Cosquer, Elodie Panzer, Noémie Penaud, Anne Pereira de Vasconcelos, Aline Stéphan, Karine Merienne, Jean-Christophe Cassel, Chantal Mathis, Frédéric Blanc, Olivier Bousiges, Anne-Laurence Boutillier
Publikováno v:
Neurobiology of Disease, Vol 201, Iss , Pp 106676- (2024)
Background: Dementia with Lewy bodies (DLB) is the second most common age-related neurocognitive pathology after Alzheimer's disease. Animal models characterizing this disease are lacking and their development would ameliorate both the understanding
Externí odkaz:
https://doaj.org/article/d3ffd1bc14cc41549b6e377f048019ea
Autor:
Yuhki Koike, Yuki Sato, Koki Higashi, Yuka Nagano, Shimura Tadanobu, Takahito Kitajima, Kohei Matsushita, Yoshinaga Okugawa, Akira Mizoguchi, Yuji Toiyama
Publikováno v:
Journal of Pediatric Surgery Open, Vol 8, Iss , Pp 100125- (2024)
Live imaging of experimental animals is now possible thanks to recent technological advances that overcome the limitations of conventional histological analysis. In contrast to conventional histological microscopy techniques, this intravital approach
Externí odkaz:
https://doaj.org/article/3de6421928d847619cd5d59d7db17ee9
Autor:
Livia Breznik, Magdalena Daurer, Roland Rabl, Tina Loeffler, Estibaliz Etxeberria-Rekalde, Joerg Neddens, Stefanie Flunkert, Manuela Prokesch
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
BackgroundParkinson’s disease (PD) is a debilitating neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons and the accumulation of α-synuclein (α-syn) aggregates. The A53T missense point mutation occurs in autos
Externí odkaz:
https://doaj.org/article/7b4a2cab111043688b5e5efe3b8aac70
Autor:
Amanda Davenport, Chase W. Kessinger, Ryan D. Pfeiffer, Nikita Shah, Richard Xu, E. Dale Abel, Nathan R. Tucker, Zhiqiang Lin
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 9, Iss , Pp 100081- (2024)
We have previously shown that the Myh6 promoter drives Cre expression in a subset of male germ line cells in three independent Myh6-Cre mouse lines, including two transgenic lines and one knock-in allele. In this study, we further compared the tissue
Externí odkaz:
https://doaj.org/article/939b965e49d341b48bd2b18c3a47eca5