Dissecting the genetic heterogeneity of gastric cancerResearch in context

Autor: Timo Hess, Carlo Maj, Jan Gehlen, Oleg Borisov, Stephan L. Haas, Ines Gockel, Michael Vieth, Guillaume Piessen, Hakan Alakus, Yogesh Vashist, Carina Pereira, Michael Knapp, Vitalia Schüller, Alexander Quaas, Heike I. Grabsch, Jessica Trautmann, Ewa Malecka-Wojciesko, Anna Mokrowiecka, Jan Speller, Andreas Mayr, Julia Schröder, Axel M. Hillmer, Dominik Heider, Florian Lordick, Ángeles Pérez-Aísa, Rafael Campo, Jesús Espinel, Fernando Geijo, Concha Thomson, Luis Bujanda, Federico Sopeña, Ángel Lanas, María Pellisé, Claudia Pauligk, Thorsten Oliver Goetze, Carolin Zelck, Julian Reingruber, Emadeldin Hassanin, Peter Elbe, Sandra Alsabeah, Mats Lindblad, Magnus Nilsson, Nicole Kreuser, René Thieme, Francesca Tavano, Roberta Pastorino, Dario Arzani, Roberto Persiani, Jin-On Jung, Henrik Nienhüser, Katja Ott, Ralf R. Schumann, Oliver Kumpf, Susen Burock, Volker Arndt, Anna Jakubowska, Małgorzta Ławniczak, Victor Moreno, Vicente Martín, Manolis Kogevinas, Marina Pollán, Justyna Dąbrowska, Antonio Salas, Olivier Cussenot, Anne Boland-Auge, Delphine Daian, Jean-Francois Deleuze, Erika Salvi, Maris Teder-Laving, Gianluca Tomasello, Margherita Ratti, Chiara Senti, Valli De Re, Agostino Steffan, Arnulf H. Hölscher, Katharina Messerle, Christiane Josephine Bruns, Armands Sīviņš, Inga Bogdanova, Jurgita Skieceviciene, Justina Arstikyte, Markus Moehler, Hauke Lang, Peter P. Grimminger, Martin Kruschewski, Nikolaos Vassos, Claus Schildberg, Philipp Lingohr, Karsten Ridwelski, Hans Lippert, Nadine Fricker, Peter Krawitz, Per Hoffmann, Markus M. Nöthen, Lothar Veits, Jakob R. Izbicki, Adrianna Mostowska, Federico Martinón-Torres, Daniele Cusi, Rolf Adolfsson, Geraldine Cancel-Tassin, Aksana Höblinger, Ernst Rodermann, Monika Ludwig, Gisela Keller, Andres Metspalu, Hermann Brenner, Joerg Heller, Markus Neef, Michael Schepke, Franz Ludwig Dumoulin, Lutz Hamann, Renato Cannizzaro, Michele Ghidini, Dominik Plaßmann, Michael Geppert, Peter Malfertheiner, Olivier Gehlen, Tomasz Skoczylas, Marek Majewski, Jan Lubiński, Orazio Palmieri, Stefania Boccia, Anna Latiano, Nuria Aragones, Thomas Schmidt, Mário Dinis-Ribeiro, Rui Medeiros, Salah-Eddin Al-Batran, Mārcis Leja, Juozas Kupcinskas, María A. García-González, Marino Venerito, Johannes Schumacher

Publikováno v: EBioMedicine, Vol 92, Iss , Pp 104616- (2023)

Summary: Background: Gastric cancer (GC) is clinically heterogenous according to location (cardia/non-cardia) and histopathology (diffuse/intestinal). We aimed to characterize the genetic risk architecture of GC according to its subtypes. Another aim

Externí odkaz: https://doaj.org/article/bec8e38288e64b4d97506fb3356c481a

Transcriptome-wide association study identified candidate genes associated with gut microbiota

Autor: Chuyu Pan, Yujie Ning, Yumeng Jia, Shiqiang Cheng, Yan Wen, Xuena Yang, Peilin Meng, Chun’e Li, Huijie Zhang, Yujing Chen, Jingxi Zhang, Zhen Zhang, Feng Zhang

Publikováno v: Gut Pathogens, Vol 13, Iss 1, Pp 1-12 (2021)

Abstract Background Gut microbiota is closely associated with host health and disease occurrence. Host genetic factor plays an important role in shaping gut microbial communities. The specific mechanism of host-regulated gene expression affecting gut

Externí odkaz: https://doaj.org/article/15beb6dc4dd44c0e9eeaec1b7dd3b6bd

Integrating transcriptome-wide association study and mRNA expression profile identified candidate genes related to hand osteoarthritis

Autor: Jiawen Xu, Yi Zeng, Haibo Si, Yuan Liu, Mingyang Li, Junfeng Zeng, Bin Shen

Publikováno v: Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-7 (2021)

Abstract Background Osteoarthritis (OA) is a common skeletal system disease that has been partially attributed to genetic factors. The hand is frequently affected, which seriously affects the patient’s quality of life. However, the pathogenetic mec

Externí odkaz: https://doaj.org/article/669fec693e3347f99df67e83818b3056

Transcriptome-wide association study identifies susceptibility genes for rheumatoid arthritis

Autor: Cuiyan Wu, Sijian Tan, Li Liu, Shiqiang Cheng, Peilin Li, Wenyu Li, Huan Liu, Feng’e Zhang, Sen Wang, Yujie Ning, Yan Wen, Feng Zhang

Publikováno v: Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-10 (2021)

Abstract Objective To identify rheumatoid arthritis (RA)-associated susceptibility genes and pathways through integrating genome-wide association study (GWAS) and gene expression profile data. Methods A transcriptome-wide association study (TWAS) was

Externí odkaz: https://doaj.org/article/28313827f208418492f5a5a6b1e12786

Genome- and Transcriptome-Wide Association Studies Identify Susceptibility Genes and Pathways for Periodontitis

Autor: Guirong Zhu, Xing Cui, Liwen Fan, Yongchu Pan, Lin Wang

Publikováno v: Cells, Vol 12, Iss 1, p 70 (2022)

Several genes associated with periodontitis have been identified through genome-wide association studies (GWAS); however, known genes only explain a minority of the estimated heritability. We aimed to explore more susceptibility genes and the underly

Externí odkaz: https://doaj.org/article/ee22f52b63994096bf495729182d3308