Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Transcriptome/genetics"'
Autor:
Lucas Massier, Jutta Jalkanen, Merve Elmastas, Jiawei Zhong, Tongtong Wang, Pamela A. Nono Nankam, Scott Frendo-Cumbo, Jesper Bäckdahl, Narmadha Subramanian, Takuya Sekine, Alastair G. Kerr, Ben T. P. Tseng, Jurga Laurencikiene, Marcus Buggert, Magda Lourda, Karolina Kublickiene, Nayanika Bhalla, Alma Andersson, Armand Valsesia, Arne Astrup, Ellen E. Blaak, Patrik L. Ståhl, Nathalie Viguerie, Dominique Langin, Christian Wolfrum, Matthias Blüher, Mikael Rydén, Niklas Mejhert
Publikováno v:
Nature Communications. 14(1)
To date, single-cell studies of human white adipose tissue (WAT) have been based on small cohort sizes and no cellular consensus nomenclature exists. Herein, we performed a comprehensive meta-analysis of publicly available and newly generated single-
Autor:
Chirag Nepal, Jesper B. Andersen
Publikováno v:
Nepal, C & Andersen, J B 2023, ' Alternative promoters in CpG depleted regions are prevalently associated with epigenetic misregulation of liver cancer transcriptomes ', Nature Communications, vol. 14, 2712 . https://doi.org/10.1038/s41467-023-38272-4
Transcriptional regulation is commonly governed by alternative promoters. However, the regulatory architecture in alternative and reference promoters, and how they differ, remains elusive. In 100 CAGE-seq libraries from hepatocellular carcinoma patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a40d8087079cfd0f686daad42602d97b
https://curis.ku.dk/ws/files/346531529/s41467_023_38272_4.pdf
https://curis.ku.dk/ws/files/346531529/s41467_023_38272_4.pdf
Publikováno v:
Genes; Volume 13; Issue 11; Pages: 2020
Sandhoff disease (SD) is a fatal neurodegenerative disorder belonging to the family of diseases called GM2 Gangliosidosis. There is no curative treatment of SD. The molecular pathogenesis of SD is still unclear though it is clear that the pathology i
Autor:
Tony Wyss-Coray, PATRICK MCALPINE, Timothy Wu, William Goodyer, Maxim Markovic, Emily Trimm, Shixuan Liu, Sevahn Vorperian, Gaetano D'Amato, Stefan Veizades, Francisco Galdos, Antoine De Morrée, Charles Chang, Alex Colville, Sean Wu, William Harper, Albert Wu, Jonathan Maltzman, David A. Relman, Stephen Chang, SoRi Jang, Bronwyn Scott
Publikováno v:
Vorperian, S K, Moufarrej, M N, Tabula Sapiens Consortium & Quake, S R 2022, ' Cell types of origin of the cell-free transcriptome ', Nature Biotechnology, vol. 40, no. 6, pp. 855-861 . https://doi.org/10.1038/s41587-021-01188-9
Cell-free RNA from liquid biopsies can be analyzed to determine disease tissue of origin. We extend this concept to identify cell types of origin using the Tabula Sapiens transcriptomic cell atlas as well as individual tissue transcriptomic cell atla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc120b4438acb8acaf4e2ef8ad1c565
https://pure.au.dk/portal/da/publications/cell-types-of-origin-of-the-cellfree-transcriptome(b13ff523-5d03-4f5c-8d0a-e0965dfe7c6c).html
https://pure.au.dk/portal/da/publications/cell-types-of-origin-of-the-cellfree-transcriptome(b13ff523-5d03-4f5c-8d0a-e0965dfe7c6c).html
Autor:
Martijn Wehrens, Anne E. de Leeuw, Maya Wright-Clark, Joep E.C. Eding, Cornelis J. Boogerd, Bas Molenaar, Petra H. van der Kraak, Diederik W.D. Kuster, Jolanda van der Velden, Michelle Michels, Aryan Vink, Eva van Rooij
Publikováno v:
Cell Reports, 39(6). Cell Press
Cell Reports, 39(6):110809. Cell Press
Wehrens, M, de Leeuw, A E, Wright-Clark, M, Eding, J E C, Boogerd, C J, Molenaar, B, van der Kraak, P H, Kuster, D W D, van der Velden, J, Michels, M, Vink, A & van Rooij, E 2022, ' Single-cell transcriptomics provides insights into hypertrophic cardiomyopathy ', Cell Reports, vol. 39, no. 6, 110809 . https://doi.org/10.1016/j.celrep.2022.110809
Cell Reports, 39(6):110809. Cell Press
Wehrens, M, de Leeuw, A E, Wright-Clark, M, Eding, J E C, Boogerd, C J, Molenaar, B, van der Kraak, P H, Kuster, D W D, van der Velden, J, Michels, M, Vink, A & van Rooij, E 2022, ' Single-cell transcriptomics provides insights into hypertrophic cardiomyopathy ', Cell Reports, vol. 39, no. 6, 110809 . https://doi.org/10.1016/j.celrep.2022.110809
Hypertrophic cardiomyopathy (HCM) is a genetic heart disease that is characterized by unexplained segmental hypertrophy that is usually most pronounced in the septum. While sarcomeric gene mutations are often the genetic basis for HCM, the mechanisti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f075b3620a94a6d61c3751ad132e989
https://pure.knaw.nl/portal/en/publications/78b14421-b0e9-4720-963d-1de6f43fc415
https://pure.knaw.nl/portal/en/publications/78b14421-b0e9-4720-963d-1de6f43fc415
Autor:
Jemima J. Burden, Lucy Brooks, Zane Jaunmuktane, Daniela Kocher, Simona Parrinello, Megan Woodberry, Luca Richards, Leila Zakka, Steven M. Pollard, Sebastian Brandner, Melanie Clements, Peter B. Dirks, Michael J. Ellis, Gillian Morrison, Samuel Marguerat, Sara Castro Devesa
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Brooks, L J, Clements, M P, Burden, J J, Kocher, D, Richards, L, Devesa, S C, Zakka, L, Woodberry, M, Ellis, M, Jaunmuktane, Z, Brandner, S, Morrison, G, Pollard, S M, Dirks, P B, Marguerat, S & Parrinello, S 2021, ' The white matter is a pro-differentiative niche for glioblastoma ', Nature Communications, vol. 12, no. 1, pp. 2184 . https://doi.org/10.1038/s41467-021-22225-w
Nature Communications
Brooks, L J, Clements, M P, Burden, J J, Kocher, D, Richards, L, Devesa, S C, Zakka, L, Woodberry, M, Ellis, M, Jaunmuktane, Z, Brandner, S, Morrison, G, Pollard, S M, Dirks, P B, Marguerat, S & Parrinello, S 2021, ' The white matter is a pro-differentiative niche for glioblastoma ', Nature Communications, vol. 12, no. 1, pp. 2184 . https://doi.org/10.1038/s41467-021-22225-w
Nature Communications
Glioblastomas are hierarchically organised tumours driven by glioma stem cells that retain partial differentiation potential. Glioma stem cells are maintained in specialised microenvironments, but whether, or how, they undergo lineage progression out
Autor:
Hoda, Uruj, Pavlidis, Stelios, Bansal, Aruna T, Takahashi, Kentaro, Hu, Sile, Ng Kee Kwong, Francois, Rossios, Christos, Sun, Kai, Bhavsar, Pankaj, Loza, Matthew, Baribaud, Frederic, Chanez, Pascal, Fowler, Stephen J, Horvath, Ildiko, Montuschi, Paolo, Singer, Florian, Musial, Jacek, Dahlen, Barbro, Krug, Norbert, Sandstrom, Thomas, Shaw, Dominic E, Lutter, Rene, Fleming, Louise J, Howarth, Peter H, Caruso, Massimo, Sousa, Ana R, Corfield, Julie, Auffray, Charles, De Meulder, Bertrand, Lefaudeux, Diane, Dahlen, Sven-Erik, Djukanovic, Ratko, Sterk, Peter J, Guo, Yike, Adcock, Ian M, Chung, Kian Fan
Publikováno v:
Hoda, Uruj; Pavlidis, Stelios; Bansal, Aruna T; Takahashi, Kentaro; Hu, Sile; Ng Kee Kwong, Francois; Rossios, Christos; Sun, Kai; Bhavsar, Pankaj; Loza, Matthew; Baribaud, Frederic; Chanez, Pascal; Fowler, Stephen J; Horvath, Ildiko; Montuschi, Paolo; Singer, Florian; Musial, Jacek; Dahlen, Barbro; Krug, Norbert; Sandstrom, Thomas; ... (2022). Clinical and transcriptomic features of persistent exacerbation-prone severe asthma in U-BIOPRED cohort. Clinical and translational medicine, 12(4), e816. 10.1002/ctm2.816
Clinical and translational medicine, 12(4):10.1002/ctm2.816. Springer Verlag
U-BIOPRED Study Group 2022, ' Clinical and transcriptomic features of persistent exacerbation-prone severe asthma in U-BIOPRED cohort ', Clinical and Translational Medicine, vol. 12, no. 4, e816 . https://doi.org/10.1002/ctm2.816
Clinical and translational medicine, 12(4):10.1002/ctm2.816. Springer Verlag
U-BIOPRED Study Group 2022, ' Clinical and transcriptomic features of persistent exacerbation-prone severe asthma in U-BIOPRED cohort ', Clinical and Translational Medicine, vol. 12, no. 4, e816 . https://doi.org/10.1002/ctm2.816
BACKGROUND: Exacerbation-prone asthma is a feature of severe disease. However, the basis for its persistency remains unclear.OBJECTIVES: To determine the clinical and transcriptomic features of frequent exacerbators (FEs) and persistent FEs (PFEs) in
Autor:
Ingeborg B. Hooijkaas, Gerard J.J. Boink, Phil Barnett, Vincent Wakker, Jan Hendrik van Weerd, Mathilda T.M. Mommersteeg, Karel van Duijvenboden, Rajiv A Mohan, Jeroen Bakkers, Jianan Wang, Fernanda M Bosada, Bas J. Boukens, Ruben Coronel, Corrie de Gier-de Vries, Vincent M. Christoffels
Publikováno v:
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 117(31), 18617-18626. National Academy of Sciences
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, 117(31), 18617-18626. National Academy of Sciences
Proc Natl Acad Sci U S A
Genome-wide association studies have identified noncoding variants near TBX3 that are associated with PR interval and QRS duration, suggesting that subtle changes in TBX3 expression affect atrioventricular conduction system function. To explore wheth
Autor:
Gemma Moncunill, Jason Carnes, William Chad Young, Lindsay Carpp, Stephen De Rosa, Joseph J Campo, Augusto Nhabomba, Maxmillian Mpina, Chenjerai Jairoce, Greg Finak, Paige Haas, Carl Muriel, Phu Van, Héctor Sanz, Sheetij Dutta, Benjamin Mordmüller, Selidji T Agnandji, Núria Díez-Padrisa, Nana Aba Williams, John J Aponte, Clarissa Valim, Daniel E Neafsey, Claudia Daubenberger, M Juliana McElrath, Carlota Dobaño, Ken Stuart, Raphael Gottardo
Publikováno v:
eLife, Vol 11 (2022)
eLife
eLife, vol. 11, pp. e70393
eLife
eLife, vol. 11, pp. e70393
Background:In a phase 3 trial in African infants and children, the RTS,S/AS01 vaccine (GSK) showed moderate efficacy against clinical malaria. We sought to further understand RTS,S/AS01-induced immune responses associated with vaccine protection.Meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f39dda5f2f260731aea5887d8a00c2
Autor:
Ao Chen, Sha Liao, Mengnan Cheng, Kailong Ma, Liang Wu, Yiwei Lai, Xiaojie Qiu, Jin Yang, Jiangshan Xu, Shijie Hao, Xin Wang, Huifang Lu, Xi Chen, Xing Liu, Xin Huang, Zhao Li, Yan Hong, Yujia Jiang, Jian Peng, Shuai Liu, Mengzhe Shen, Chuanyu Liu, Quanshui Li, Yue Yuan, Xiaoyu Wei, Huiwen Zheng, Weimin Feng, Zhifeng Wang, Yang Liu, Zhaohui Wang, Yunzhi Yang, Haitao Xiang, Lei Han, Baoming Qin, Pengcheng Guo, Guangyao Lai, Pura Muñoz-Cánoves, Patrick H. Maxwell, Jean Paul Thiery, Qing-Feng Wu, Fuxiang Zhao, Bichao Chen, Mei Li, Xi Dai, Shuai Wang, Haoyan Kuang, Junhou Hui, Liqun Wang, Ji-Feng Fei, Ou Wang, Xiaofeng Wei, Haorong Lu, Bo Wang, Shiping Liu, Ying Gu, Ming Ni, Wenwei Zhang, Feng Mu, Ye Yin, Huanming Yang, Michael Lisby, Richard J. Cornall, Jan Mulder, Mathias Uhlén, Miguel A. Esteban, Yuxiang Li, Longqi Liu, Xun Xu, Jian Wang
Publikováno v:
Chen, A, Liao, S, Cheng, M, Ma, K, Wu, L, Lai, Y, Qiu, X, Yang, J, Xu, J, Hao, S, Wang, X, Lu, H, Chen, X, Liu, X, Huang, X, Li, Z, Hong, Y, Jiang, Y, Peng, J, Liu, S, Shen, M, Liu, C, Li, Q, Yuan, Y, Wei, X, Zheng, H, Feng, W, Wang, Z, Liu, Y, Wang, Z, Yang, Y, Xiang, H, Han, L, Qin, B, Guo, P, Lai, G, Muñoz-Cánoves, P, Maxwell, P H, Thiery, J P, Wu, Q-F, Zhao, F, Chen, B, Li, M, Dai, X, Wang, S, Kuang, H, Hui, J, Wang, L, Fei, J-F, Wang, O, Wei, X, Lu, H, Wang, B, Liu, S, Gu, Y, Ni, M, Zhang, W, Mu, F, Yin, Y, Yang, H, Lisby, M, Cornall, R J, Mulder, J, Uhlén, M, Esteban, M A, Li, Y, Liu, L, Xu, X & Wang, J 2022, ' Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays ', Cell, vol. 185, no. 10, pp. 1777-1792.e21 . https://doi.org/10.1016/j.cell.2022.04.003
Spatially resolved transcriptomic technologies are promising tools to study complex biological processes such as mammalian embryogenesis. However, the imbalance between resolution, gene capture, and field of view of current methodologies precludes th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fabc9798c1368f1bac28825cf4ea3d4b
https://curis.ku.dk/portal/da/publications/spatiotemporal-transcriptomic-atlas-of-mouse-organogenesis-using-dna-nanoballpatterned-arrays(dd123904-163c-4267-bf46-c612c3bc3492).html
https://curis.ku.dk/portal/da/publications/spatiotemporal-transcriptomic-atlas-of-mouse-organogenesis-using-dna-nanoballpatterned-arrays(dd123904-163c-4267-bf46-c612c3bc3492).html