Cyclin-dependent kinase 6 phosphorylates NF-κB P65 at serine 536 and contributes to the regulation of inflammatory gene expression

Autor: Buss, H, Handschick, K, Jurrmann, N, Pekkonen, P, Beuerlein, K, Müller, H, Wait, R, Saklatvala, J, Ojala, PM, Schmitz, ML, Naumann, M, Kracht, M

Publikováno v: PLoS ONE
PLoS ONE, Vol 7, Iss 12, p e51847 (2012)

Nuclear factor kappa-B (NF-κB) activates multiple genes with overlapping roles in cell proliferation, inflammation and cancer. Using an unbiased approach we identified human CDK6 as a novel kinase phosphorylating NF-κB p65 at serine 536. Purified a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::110dfb522e2af814da67a5bca1a95688
https://ora.ox.ac.uk/objects/uuid:46ac7aa8-4528-4b4d-902d-cfb9c59aebf2

A general pairwise interaction model provides an accurate description of in vivo transcription factor binding sites

Autor: Vincent Hakim, Thierry Mora, Marc Santolini

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2014, 9 (6), pp.e99015. ⟨10.1371/journal.pone.0099015⟩
PLoS ONE, 2014, 9 (6), pp.e99015. ⟨10.1371/journal.pone.0099015⟩
PLoS ONE, Vol 9, Iss 6, p e99015 (2014)

International audience; The identification of transcription factor binding sites (TFBSs) on genomic DNA is of crucial importance for understanding and predicting regulatory elements in gene networks. TFBS motifs are commonly described by Position Wei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98b3f69c200713ac45ee060f523f1642
https://hal.sorbonne-universite.fr/hal-01369512

A Novel Function for Lysyl Oxidase in Pluripotent Mesenchymal Cell Proliferation and Relevance to Inflammation-Associated Osteopenia

Autor: Roozbeh Khosravi, Manish V. Bais, Michael Faibish, Philip C. Trackman, Wan-Peng Xu, Katharine L. Sodek, Debashree Saxena

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 6, p e100669 (2014)

Lysyl oxidase is a multifunctional enzyme required for collagen biosynthesis. Various growth factors regulate lysyl oxidase during osteoblast differentiation, subject to modulation by cytokines such as TNF-α in inflammatory osteopenic disorders incl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303346a2e9741d7d99ed8e51e8a6919c
http://europepmc.org/articles/PMC4074096

Response regulator heterodimer formation controls a key stage in Streptomyces development

Autor: Matthew J. Bush, Mahmoud M. Al-Bassam, Mark J. Buttner, Govind Chandra, Maureen J. Bibb

Publikováno v: PLoS Genetics
PLoS Genetics, Vol 10, Iss 8, p e1004554 (2014)

The orphan, atypical response regulators BldM and WhiI each play critical roles in Streptomyces differentiation. BldM is required for the formation of aerial hyphae, and WhiI is required for the differentiation of these reproductive structures into m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e805fcebb6e21bddf615b63aef7aefdb
https://pubmed.ncbi.nlm.nih.gov/25101778

Transcriptional Regulation of YWHAZ, the Gene Encoding 14-3-3ζ

Autor: Fadlo R. Khuri, Andrea L. Kasinski, Haian Fu, Xue-Yuan Dong, Jeremy M. Boss

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 4, p e93480 (2014)

Aberrant expression of oncogenic 14-3-3 proteins is correlated with poor survival of cancer patients. While the underlying mechanism of the abnormal expression in tumors remains elusive for the six oncogenic 14-3-3 isoforms; the potential involvement

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11563c5397bdd96b053dfbde4a747e6f
http://europepmc.org/articles/PMC3972145