TPX2 overexpression promotes sensitivity to dasatinib in breast cancer by activating YAP transcriptional signaling

Autor: Carlos Marugán, Natalia Sanz‐Gómez, Beatriz Ortigosa, Ana Monfort‐Vengut, Cristina Bertinetti, Ana Teijo, Marta González, Alicia Alonso de la Vega, María José Lallena, Gema Moreno‐Bueno, Guillermo deCárcer

Publikováno v: Molecular Oncology, Vol 18, Iss 6, Pp 1531-1551 (2024)

Chromosomal instability (CIN) is a hallmark of cancer aggressiveness, providing genetic plasticity and tumor heterogeneity that allows the tumor to evolve and adapt to stress conditions. CIN is considered a cancer therapeutic biomarker because health

Externí odkaz: https://doaj.org/article/3ef5cfa6ef0a445999dcca9dcaa443a0

Synapse-to-nucleus ERK-CREB transcriptional signaling requires dendrite-to-soma Ca ²⁺ propagation mediated by L-type voltage-gated Ca ²⁺ channels.

Autor: Zent KH; Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.; Neuroscience Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045., Dell'Acqua ML; Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045. mark.dellacqua@cuanschutz.edu.; Neuroscience Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.; Neurotechnology Center, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2024 Nov 19. Date of Electronic Publication: 2024 Nov 19.

Ulmoidol, an unusual nortriterpenoid from Eucommia ulmoides Oliv. Leaves prevents neuroinflammation by targeting the PU.1 transcriptional signaling pathway

Autor: Han, Rui, Yuan, Tian, Yang, Zhi, Zhang, Qiang, Wang, Wei-Wei, Lin, Li-Bin, Zhu, Ming-Qiang, Gao, Jin-Ming

Publikováno v: In Bioorganic Chemistry November 2021 116

Activation of human aortic valve interstitial cells by local stiffness involves YAP-dependent transcriptional signaling

Autor: Santoro, Rosaria, Scaini, Denis, Severino, Luisa Ulloa, Amadeo, Francesco, Ferrari, Silvia, Bernava, Giacomo, Garoffolo, Gloria, Agrifoglio, Marco, Casalis, Loredana, Pesce, Maurizio

Publikováno v: In Biomaterials October 2018 181:268-279

Immunological Feature and Transcriptional Signaling of Ly6C Monocyte Subsets From Transcriptome Analysis in Control and Hyperhomocysteinemic Mice

Autor: Pingping Yang, Lu Liu, Lizhe Sun, Pu Fang, Nathaniel Snyder, Jason Saredy, Yong Ji, Wen Shen, Xuebin Qin, Qinghua Wu, Xiaofeng Yang, Hong Wang

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

BackgroundMurine monocytes (MC) are classified into Ly6Chigh and Ly6Clow MC. Ly6Chigh MC is the pro-inflammatory subset and the counterpart of human CD14++CD16+ intermediate MC which contributes to systemic and tissue inflammation in various metaboli

Externí odkaz: https://doaj.org/article/a8a7b11ac012464b8196e17a1d87123b