Zobrazeno 1 - 10
of 78 238
pro vyhledávání: '"Transcriptional regulation"'
Publikováno v:
Biology Direct, Vol 19, Iss 1, Pp 1-16 (2024)
Abstract Precise regulation of gene expression is crucial to development. Enhancers, the core of gene regulation, determine the spatiotemporal pattern of gene transcription. Since many disease-associated mutations are characterized in enhancers, the
Externí odkaz:
https://doaj.org/article/6b6ad82c3d9a4dd8bd383dbbaefd24d7
Autor:
Daniel del Valle-Morales, Giulia Romano, Giovanni Nigita, Michela Saviana, Alessandro La Ferlita, Patricia Le, Rachel Brown, Lavender Micalo, Howard Li, Patrick Nana-Sinkam, Mario Acunzo
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The 5’ cap, catalyzed by RNA guanylyltransferase and 5’-phosphatase (RNGTT), is a vital mRNA modification for the functionality of mRNAs. mRNA capping occurs in the nucleus for the maturation of the functional mRNA and in the cytoplasm f
Externí odkaz:
https://doaj.org/article/1393fe678efa464480c300798d097763
Autor:
Yuan Tian, Shumin Wang, Youchu Ma, Yanling Li, Rui Li, Youxiu Fu, Rui Zhang, Rui Zhu, Fanglong Zhao
Publikováno v:
Microbial Cell Factories, Vol 23, Iss 1, Pp 1-12 (2024)
Abstract Background Echinocandin B (ECB) is a key precursor of the antifungal drug anidulafungin and its biosynthesis occurs via ani gene cluster in Aspergillus nidulans NRRL8112. Strain improvement for industrial ECB production has mainly relied on
Externí odkaz:
https://doaj.org/article/26c4d5836846489686702bd955885fd3
Publikováno v:
Journal of Biological Engineering, Vol 18, Iss 1, Pp 1-11 (2024)
Abstract Background De-novo-designed synthetic transcriptional regulators have great potential as the genetic parts for constructing complex multilayered gene circuits. The design flexibility afforded by advanced nucleic acid sequence design tools va
Externí odkaz:
https://doaj.org/article/f4a036bc28c547c4bc5b2e0b7737de05
Autor:
Bo Hong, Bingqian Zhou, Dongfang Zhao, Li Liao, Tao Chang, Xuepeng Wu, Junjie Wu, Mingyao Yao, Hu Chen, Jiajun Mao, Chunyun Guan, Mei Guan
Publikováno v:
BMC Plant Biology, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Rapeseed (Brassica napus L.) is a major oilseed crop in the middle and lower reaches of the Yangtze River in China. However, it is susceptible to waterlogging stress. This study aimed to investigate the physiological characteristics, cellula
Externí odkaz:
https://doaj.org/article/4be34299ddcb4c5082632e59d4864924
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Hyperactive RNA Polymerase I (Pol I) transcription is canonical in cancer, associated with malignant proliferation, poor prognosis, epithelial-mesenchymal transition, and chemotherapy resistance. Despite its significance, the mole
Externí odkaz:
https://doaj.org/article/54681d1495d3485995fd919957afd267
Autor:
Roswitha Dolcemascolo, Raúl Ruiz, Sara Baldanta, Lucas Goiriz, María Heras-Hernández, Roser Montagud-Martínez, Guillermo Rodrigo
Publikováno v:
Journal of Biological Engineering, Vol 18, Iss 1, Pp 1-11 (2024)
Abstract RNA recognition motifs (RRMs) are widespread RNA-binding protein domains in eukaryotes, which represent promising synthetic biology tools due to their compact structure and efficient activity. Yet, their use in prokaryotes is limited and the
Externí odkaz:
https://doaj.org/article/a029a97bc8f84f8d983d20ef3d793484