Zobrazeno 1 - 10
of 366
pro vyhledávání: '"Transcription factors/metabolism"'
Autor:
Antoine Cherix, Carole Poitry-Yamate, Bernard Lanz, Olivia Zanoletti, Jocelyn Grosse, Carmen Sandi, Rolf Gruetter, Jean-René Cardinaux
Publikováno v:
Molecular psychiatry, vol. 27, no. 11, pp. 4485-4501
Mood disorders (MD) are a major burden on society as their biology remains poorly understood, challenging both diagnosis and therapy. Among many observed biological dysfunctions, homeostatic dysregulation, such as metabolic syndrome (MeS), shows cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5213e063e9f81d98c03e8a176ea893b
https://doi.org/10.1038/s41380-022-01791-5
https://doi.org/10.1038/s41380-022-01791-5
Autor:
Yohan Bignon, Leonore Wigger, Camille Ansermet, Benjamin D. Weger, Sylviane Lagarrigue, Gabriel Centeno, Fanny Durussel, Lou Götz, Mark Ibberson, Sylvain Pradervand, Manfredo Quadroni, Meltem Weger, Francesca Amati, Frédéric Gachon, Dmitri Firsov
Publikováno v:
The Journal of clinical investigation, vol. 133, no. 8, pp. e167133
Circadian rhythmicity in renal function suggests rhythmic adaptations in renal metabolism. To decipher the role of the circadian clock in renal metabolism, we studied diurnal changes in renal metabolic pathways using integrated transcriptomic, proteo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d501b1fe0253e85384d3683701b95c2
https://serval.unil.ch/resource/serval:BIB_D6C488B3AAAF.P001/REF.pdf
https://serval.unil.ch/resource/serval:BIB_D6C488B3AAAF.P001/REF.pdf
Autor:
Yu Ting Ong, Jorge Andrade, Max Armbruster, Chenyue Shi, Marco Castro, Ana S. H. Costa, Toshiya Sugino, Guy Eelen, Barbara Zimmermann, Kerstin Wilhelm, Joseph Lim, Shuichi Watanabe, Stefan Guenther, Andre Schneider, Francesca Zanconato, Manuel Kaulich, Duojia Pan, Thomas Braun, Holger Gerhardt, Alejo Efeyan, Peter Carmeliet, Stefano Piccolo, Ana Rita Grosso, Michael Potente
Publikováno v:
Nature Metabolism
Funding Information: The research in the M.P. laboratory was supported by the Max Planck Society, the European Research Council (ERC) Consolidator Grant EMERGE (no. 773047), the Deutsche Forschungsgemeinschaft (DFG, Project-ID 75732319 – SFB 834),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::949e298d1cb95c83b830f240881e3703
https://doi.org/10.1038/s42255-022-00584-y
https://doi.org/10.1038/s42255-022-00584-y
Autor:
Katsioudi, Georgia, Dreos, René, Arpa, Enes S, Gaspari, Sevasti, Liechti, Angelica, Sato, Miho, Gabriel, Christian H, Kramer, Achim, Brown, Steven A, Gatfield, David
Publikováno v:
Science advances, vol. 9, no. 2, pp. eade2828
Nonsense-mediated messenger RNA (mRNA) decay (NMD) has been intensively studied as a surveillance pathway that degrades erroneous transcripts arising from mutations or RNA processing errors. While additional roles in physiological control of mRNA sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c26e42d3398f0e363d17171202a4fab3
Publikováno v:
Nucleic Acids Research
Ji, Z, Li, Y, Liu, S X & Sharrocks, A 2021, ' The forkhead transcription factor FOXK2 premarks lineage-specific genes in human embryonic stem cells for activation during differentiation ', Nucleic acids research, vol. 49, no. 3, gkaa1281, pp. 1345-1363 . https://doi.org/10.1093/nar/gkaa1281
Ji, Z, Li, Y, Liu, S X & Sharrocks, A 2021, ' The forkhead transcription factor FOXK2 premarks lineage-specific genes in human embryonic stem cells for activation during differentiation ', Nucleic acids research, vol. 49, no. 3, gkaa1281, pp. 1345-1363 . https://doi.org/10.1093/nar/gkaa1281
Enhancers play important roles in controlling gene expression in a choreographed spatial and temporal manner during development. However, it is unclear how these regulatory regions are established during differentiation. Here we investigated the geno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6e96e56bc9b30f2609486706e78cc23
http://europepmc.org/articles/PMC7897486
http://europepmc.org/articles/PMC7897486
Autor:
Rafael Romero, Sheila Cárcel, Judith Mazariegos, Coral Vivancos, Kerstin Bartscherer, Susanna Fraguas, Thileepan Sekaran, Jordi Ginés, Ma Dolores Molina, Francesc Cebrià
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Developmental Biology, 476, 53-67. Academic Press
Universidad de Barcelona
Developmental Biology, 476, 53-67. Academic Press
In developmental biology, the regulation of stem cell plasticity and differentiation remains an open question. CBP(CREB-binding protein)/p300 is a conserved gene family that functions as a transcriptional co-activator and plays important roles in a w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1f817d3a2e99c473b1939eed0511b1
https://doi.org/10.1016/j.ydbio.2021.02.008
https://doi.org/10.1016/j.ydbio.2021.02.008
Autor:
Lauren Kane, Iain Williamson, Ilya M. Flyamer, Yatendra Kumar, Robert E. Hill, Laura A. Lettice, Wendy A. Bickmore
Publikováno v:
Kane, L, Williamson, I, Flyamer, I, Kumar, Y, Hill, R E, Lettice, L A & Bickmore, W A 2022, ' Cohesin is required for long-range enhancer action at the Shh locus ', Nature Structural & Molecular Biology, vol. 29, no. 9, pp. 891-897 . https://doi.org/10.1038/s41594-022-00821-8
Nat Struct Mol Biol
Nat Struct Mol Biol
The regulatory landscapes of developmental genes in mammals can be complex, with enhancers spread over many hundreds of kilobases. It has been suggested that three-dimensional genome organisation, particularly topologically associating domains formed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005cf46e25b276610ee986e6f1825e97
https://www.pure.ed.ac.uk/ws/files/288068812/Kane_NSMB_accepted.pdf
https://www.pure.ed.ac.uk/ws/files/288068812/Kane_NSMB_accepted.pdf
Autor:
Daiß, Julia L., Pilsl, Michael, Straub, Kristina, Bleckmann, Andrea, Höcherl, Mona, Heiss, Florian B., Abascal-Palacios, Guillermo, Ramsay, Ewan Phillip, Tlučková, Katarina, Mars, Jean-Clement, Fürtges, Torben, Bruckmann, Astrid, Rudack, Till, Bernecky, Carrie, Lamour, Valérie, Panov, Konstantin, Vannini, Alessandro, Moss, Tom, Engel, Christoph
Publikováno v:
Life Science Alliance
Life Science Alliance, 2022, 5 (11), pp.e202201568. ⟨10.26508/lsa.202201568⟩
Daiß, J L, Pilsl, M, Straub, K, Bleckmann, A, Höcherl, M, Heiss, F B, Abascal-Palacios, G, Ramsay, E P, Tlučková, K, Mars, J-C, Fürtges, T, Bruckmann, A, Rudack, T, Bernecky, C, Lamour, V, Panov, K, Vannini, A, Moss, T & Engel, C 2022, ' The human RNA polymerase I structure reveals an HMG-like docking domain specific to metazoans ', Life Science Alliance, vol. 5, no. 11, e202201568 . https://doi.org/10.26508/lsa.202201568
Life Science Alliance, 2022, 5 (11), pp.e202201568. ⟨10.26508/lsa.202201568⟩
Daiß, J L, Pilsl, M, Straub, K, Bleckmann, A, Höcherl, M, Heiss, F B, Abascal-Palacios, G, Ramsay, E P, Tlučková, K, Mars, J-C, Fürtges, T, Bruckmann, A, Rudack, T, Bernecky, C, Lamour, V, Panov, K, Vannini, A, Moss, T & Engel, C 2022, ' The human RNA polymerase I structure reveals an HMG-like docking domain specific to metazoans ', Life Science Alliance, vol. 5, no. 11, e202201568 . https://doi.org/10.26508/lsa.202201568
Transcription of the ribosomal RNA precursor by RNA polymerase (Pol) I is a major determinant of cellular growth, and dysregulation is observed in many cancer types. Here, we present the purification of human Pol I from cells carrying a genomic GFP f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c5a494af75c77b57e597eca946ccaa
https://epub.uni-regensburg.de/52860/
https://epub.uni-regensburg.de/52860/
Autor:
Alessandro Tancredi, Olga Gusyatiner, Pierre Bady, Michelle C. Buri, Rémy Lomazzi, Davide Chiesi, Mahmoud Messerer, Monika E. Hegi
Publikováno v:
Cell death & disease, vol. 13, no. 12, pp. 1037
Bromodomain and extra-terminal tail (BET) proteins have been identified as potential epigenetic targets in cancer, including glioblastoma. These epigenetic modifiers link the histone code to gene transcription that can be disrupted with small molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e8b827f62edf473e57c259b29df8a9
https://doi.org/10.21203/rs.3.rs-1832996/v1
https://doi.org/10.21203/rs.3.rs-1832996/v1
Autor:
Robert J Harris, Zena Willsmore, Roman Laddach, Silvia Crescioli, Jitesh Chauhan, Anthony Cheung, Anna Black, Jenny L. C. Geh, Alastair D MacKenzie Ross, Ciaran Healy, Sophia Tsoka, James Spicer, Katie E Lacy, Sophia N Karagiannis
Publikováno v:
Harris, R J, Willsmore, Z, Laddach, R, Crescioli, S, Chauhan, J, Cheung, A, Black, A, Geh, J L C, MacKenzie Ross, A D, Healy, C, Tsoka, S, Spicer, J, Lacy, K E & Karagiannis, S N 2022, ' Enriched circulating and tumor-resident TGF-β+ regulatory B cells in patients with melanoma promote FOXP3+ Tregs ', OncoImmunology, vol. 11, no. 1, 2104426, pp. 2104426 . https://doi.org/10.1080/2162402X.2022.2104426
B cells are emerging as key players of anti-tumor adaptive immune responses. We investigated regulatory and pro-inflammatory cytokine-expressing B cells in patients with melanoma by flow cytometric intracellular cytokine, CyTOF, transcriptomic, immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae09673c24a2cdfed4c5599d2860ce6c
https://doi.org/10.1080/2162402x.2022.2104426
https://doi.org/10.1080/2162402x.2022.2104426