Zobrazeno 1 - 10
of 988
pro vyhledávání: '"Transcription factor II E"'
SUMMARYRNA polymerase II (Pol II) transcription reconstituted from purified factors suggests pre-initiation complexes (PICs) can assemble by sequential incorporation of factors at the TATA box. However, these basal transcription reactions are general
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63bbddd0ce85c01d10553d52d002963a
Publikováno v:
Nature
nature
nature
Mediator is a conserved coactivator complex that enables the regulated initiation of transcription at eukaryotic genes1–3. Mediator is recruited by transcriptional activators and binds the pre-initiation complex (PIC) to stimulate the phosphorylati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cfe1c416b89b153e5212820cc3b8edb
https://hdl.handle.net/21.11116/0000-0009-4825-D21.11116/0000-0008-707B-021.11116/0000-000A-70F4-4
https://hdl.handle.net/21.11116/0000-0009-4825-D21.11116/0000-0008-707B-021.11116/0000-000A-70F4-4
Autor:
Stefan Steimle, Benjamin A. Garcia, Yang C, Fujiwara R, Kenji Murakami, Colón Jjg, Hyung-Jun Kim
SummaryStructural studies of the initiation-elongation transition of RNA polymerase II (pol II) transcription were previously facilitated by the use of synthetic oligonucleotides. Here we report structures of initiation complexes de novo converted fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40f013c2712d93cfa5c7f0bdf62e01f4
https://doi.org/10.1101/2021.05.03.442346
https://doi.org/10.1101/2021.05.03.442346
Mediator is a conserved coactivator that enables regulated transcription initiation from eukaryotic protein-coding genes1-3. Mediator is recruited by transcriptional activators and binds the pre-initiation complex (PIC) to stimulate RNA polymerase II
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccee6ec8a3536a36b26c3d7c67b14a52
https://doi.org/10.1101/2021.03.11.435010
https://doi.org/10.1101/2021.03.11.435010
Publikováno v:
Cell. 184(15)
Transcription initiation requires assembly of the RNA polymerase II (Pol II) pre-initiation complex (PIC) and opening of promoter DNA. Here, we present the long-sought high-resolution structure of the yeast PIC and define the mechanism of initial DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee5e8af6f118a58d26b7de08a4c9ac70
https://pubmed.ncbi.nlm.nih.gov/34297929
https://pubmed.ncbi.nlm.nih.gov/34297929
Publikováno v:
Biochemical Society transactions. 48(5)
RNA polymerase I (Pol I) is the most specialized eukaryotic Pol. It is only responsible for the synthesis of pre-ribosomal RNA (rRNA), the precursor of 18S, 5.8S and 28S rRNA, the most abundant cellular RNA types. Aberrant Pol I transcription is obse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d24c38c80fd74f336b76d0c793f799a
https://pubmed.ncbi.nlm.nih.gov/32915199
https://pubmed.ncbi.nlm.nih.gov/32915199
Autor:
Pouria Dasmeh
Publikováno v:
Journal of Theoretical Biology. 438:92-95
In heterogametic organisms, expression of unequal number of X chromosomes in males and females is balanced by a process called dosage compensation. In Drosophila and mammals, dosage compensation involves nearly two-fold up-regulation of the X chromos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7316b21b31a03b8d3dfb392e6076854a
https://doi.org/10.1016/j.jtbi.2017.11.004
https://doi.org/10.1016/j.jtbi.2017.11.004
Autor:
Donal S. Luse
Publikováno v:
Proceedings of the National Academy of Sciences. 116:22426-22428
A minimal set of general transcription factors (GTFs) is required for RNA polymerase II (pol II) to initiate transcription at promoters. For all eukaryotes, from yeast to mammals, the GTFs include TFIIA, TFIIB, TFIIE, TFIIF, TFIIH, and the TATA box b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ed43053ce88ad869f48fceae534ab57
https://doi.org/10.1073/pnas.1916582116
https://doi.org/10.1073/pnas.1916582116
Publikováno v:
Mol Cell
RNA polymerase II (RNA Pol II) transcription reconstituted from purified factors suggests pre-initiation complexes (PICs) can assemble by sequential incorporation of factors at the TATA box. However, these basal transcription reactions are generally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b66bd8e2799a58a038e24f102c1ec207
https://doi.org/10.1016/j.molcel.2021.07.025
https://doi.org/10.1016/j.molcel.2021.07.025
Publikováno v:
Transcription. 9:102-107
To prevent tumorigenesis, p53 stimulates transcription by facilitating the recruitment of the transcription machinery on target gene promoters. Cryo-Electron Microscopy studies on p53-bound RNA Polymerase II (Pol II) reveal that p53 structurally regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41b8634dc9406ea0d869c4726f8d2e38
https://doi.org/10.1080/21541264.2017.1345354
https://doi.org/10.1080/21541264.2017.1345354