Zobrazeno 1 - 10
of 1 006
pro vyhledávání: '"Transcription Factors/genetics"'
Autor:
Shapulatov, Umidjon, Van zanten, Martijn, Van hoogdalem, Mark, Meisenburg, Mara, Van hall, Alexander, Kappers, Iris, Fasano, Carlo, Facella, Paolo, Loh, Chi Cheng, Perrella, Giorgio, Van der krol, Alexander, Plant Stress Resilience, Molecular Plant Physiology, Sub Plant Stress Resilience, Sub Molecular Plant Physiology
Publikováno v:
Plant Physiology, 192(1), 582-600
Plant Physiology 192 (2023) 1
Plant Physiology, 192(1). American Society of Plant Biologists
Plant Physiology 192 (2023) 1
Plant Physiology, 192(1). American Society of Plant Biologists
Thermomorphogenesis is, among other traits, characterized by enhanced hypocotyl elongation due to the induction of auxin biosynthesis genes like YUCCA8 by transcription factors, most notably PHYTOCHROME INTERACTING FACTOR 4 (PIF4). Efficient binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78dec5780814b54905c31cae9e9fa3d3
https://dspace.library.uu.nl/handle/1874/428198
https://dspace.library.uu.nl/handle/1874/428198
Autor:
Antoine Cherix, Carole Poitry-Yamate, Bernard Lanz, Olivia Zanoletti, Jocelyn Grosse, Carmen Sandi, Rolf Gruetter, Jean-René Cardinaux
Publikováno v:
Molecular psychiatry, vol. 27, no. 11, pp. 4485-4501
Mood disorders (MD) are a major burden on society as their biology remains poorly understood, challenging both diagnosis and therapy. Among many observed biological dysfunctions, homeostatic dysregulation, such as metabolic syndrome (MeS), shows cons
Autor:
Yohan Bignon, Leonore Wigger, Camille Ansermet, Benjamin D. Weger, Sylviane Lagarrigue, Gabriel Centeno, Fanny Durussel, Lou Götz, Mark Ibberson, Sylvain Pradervand, Manfredo Quadroni, Meltem Weger, Francesca Amati, Frédéric Gachon, Dmitri Firsov
Publikováno v:
The Journal of clinical investigation, vol. 133, no. 8, pp. e167133
Circadian rhythmicity in renal function suggests rhythmic adaptations in renal metabolism. To decipher the role of the circadian clock in renal metabolism, we studied diurnal changes in renal metabolic pathways using integrated transcriptomic, proteo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d501b1fe0253e85384d3683701b95c2
https://serval.unil.ch/resource/serval:BIB_D6C488B3AAAF.P001/REF.pdf
https://serval.unil.ch/resource/serval:BIB_D6C488B3AAAF.P001/REF.pdf
Autor:
David M. Picton, Joshua D. Harling-Lee, Samuel J. Duffner, Sam C. Went, Richard D. Morgan, Jay C. D. Hinton, Tim R. Blower
Publikováno v:
Nucleic Acids Research, 2022, Vol.50(9), pp.5191-5207 [Peer Reviewed Journal]
Picton, D M, Harling-Lee, J D, Duffner, S J, Went, S C, Morgan, R D, Hinton, J C D & Blower, T R 2022, ' A widespread family of WYL-domain transcriptional regulators co-localizes with diverse phage defence systems and islands ', Nucleic Acids Research, vol. 50, no. 9, pp. 5191-5207 . https://doi.org/10.1093/nar/gkac334
Picton, D M, Harling-Lee, J D, Duffner, S J, Went, S C, Morgan, R D, Hinton, J C D & Blower, T R 2022, ' A widespread family of WYL-domain transcriptional regulators co-localizes with diverse phage defence systems and islands ', Nucleic Acids Research, vol. 50, no. 9, pp. 5191-5207 . https://doi.org/10.1093/nar/gkac334
Bacteria are under constant assault by bacteriophages and other mobile genetic elements. As a result, bacteria have evolved a multitude of systems that protect from attack. Genes encoding bacterial defence mechanisms can be clustered into “defence
Autor:
Simon Grund Sørensen, Amruta Shrikhande, Gustav Alexander Poulsgaard, Mikkel Hovden Christensen, Johanna Bertl, Britt Elmedal Laursen, Eva R Hoffmann, Jakob Skou Pedersen
Publikováno v:
Sørensen, S G, Shrikhande, A, Poulsgaard, G A, Christensen, M H, Bertl, J, Laursen, B E, Hoffmann, E R & Pedersen, J S 2023, ' Pan-cancer association of DNA repair deficiencies with whole-genome mutational patterns ', eLife, vol. 12 . https://doi.org/10.7554/eLife.81224
Sørensen, S G, Shrikhande, A, Poulsgaard, G A, Christensen, M H, Bertl, J, Laursen, B E, Hoffmann, E R & Pedersen, J S 2023, ' Pan-cancer association of DNA repair deficiencies with whole-genome mutational patterns ', eLife, vol. 12, e81224 . https://doi.org/10.7554/elife.81224
Sørensen, S G, Shrikhande, A, Poulsgaard, G A, Christensen, M H, Bertl, J, Laursen, B E, Hoffmann, E R & Pedersen, J S 2023, ' Pan-cancer association of DNA repair deficiencies with whole-genome mutational patterns ', eLife, vol. 12, e81224 . https://doi.org/10.7554/elife.81224
DNA repair deficiencies in cancers may result in characteristic mutational patterns, as exemplified by deficiency of BRCA1/2 and efficacy prediction for PARP inhibitors. We trained and evaluated predictive models for loss-of-function (LOF) of 145 ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd8fdd0c0855124ac5e59edd15de56b8
https://pure.au.dk/portal/da/publications/pancancer-association-of-dna-repair-deficiencies-with-wholegenome-mutational-patterns(6d841269-ef5f-41e2-a050-6f671e6994dd).html
https://pure.au.dk/portal/da/publications/pancancer-association-of-dna-repair-deficiencies-with-wholegenome-mutational-patterns(6d841269-ef5f-41e2-a050-6f671e6994dd).html
Autor:
Richard Cunningham, Siyang Jia, Krishna Purohit, Omar Salem, Ning Sze Hui, Yue Lin, Neil O. Carragher, Carsten Gram Hansen
Publikováno v:
Cunningham, R, Jia, S, Purohit, K, Salem, O, Sze Hui, N, Lin, Y, Carragher, N O & Hansen, C G 2023, ' YAP/TAZ activation predicts clinical outcomes in mesothelioma and is conserved in in vitro model of driver mutations ', Clinical and Translational Medicine, vol. 13, no. 2, pp. e1190 . https://doi.org/10.1002/ctm2.1190
The Hippo signalling pathway is dysregulated across a wide range of cancer types and, although driver mutations that directly affect the core Hippo components are rare, a handful is found within pleural mesothelioma (PM). PM is a deadly disease of th
Autor:
Medina-Gomez, Carolina, Mullin, Benjamin H, Chesi, Alessandra, Prijatelj, Vid, Kemp, John P, Shochat-Carvalho, Chen, Trajanoska, Katerina, Wang, Carol, Joro, Raimo, Evans, Tavia E, Schraut, Katharina E, Li-Gao, Ruifang, Ahluwalia, Tarunveer S, Zillikens, M Carola, Zhu, Kun, Mook-Kanamori, Dennis O, Evans, Daniel S, Nethander, Maria, Knol, Maria J, Thorleifsson, Gudmar, Prokic, Ivana, Zemel, Babette, Broer, Linda, McGuigan, Fiona E, van Schoor, Natasja M, Reppe, Sjur, Pawlak, Mikolaj A, Ralston, Stuart H, van der Velde, Nathalie, Lorentzon, Mattias, Stefansson, Kari, Adams, Hieab H H, Wilson, Scott G, Ikram, M Arfan, Walsh, John P, Lakka, Timo A, Gautvik, Kaare M, Wilson, James F, Orwoll, Eric S, van Duijn, Cornelia M, Bønnelykke, Klaus, Uitterlinden, Andre G, Styrkársdóttir, Unnur, Akesson, Kristina E, Spector, Timothy D, Tobias, Jonathan H, Ohlsson, Claes, Felix, Janine F, Bisgaard, Hans, Grant, Struan F A, Richards, J Brent, Evans, David M, van der Eerden, Bram, van de Peppel, Jeroen, Ackert-Bicknell, Cheryl, Karasik, David, Kague, Erika, Rivadeneira, Fernando
Publikováno v:
Medina-Gomez, C, Mullin, B H, Chesi, A, Prijatelj, V, Kemp, J P, Shochat-Carvalho, C, Trajanoska, K, Wang, C, Joro, R, Evans, T E, Schraut, K E, Li-Gao, R, Ahluwalia, T S, Zillikens, M C, Zhu, K, Mook-Kanamori, D O, Evans, D S, Nethander, M, Knol, M J, Thorleifsson, G, Prokic, I, Zemel, B, Broer, L, McGuigan, F E, van Schoor, N M, Reppe, S, Pawlak, M A, Ralston, S H, van der Velde, N, Lorentzon, M, Stefansson, K, Adams, H H H, Wilson, S G, Ikram, M A, Walsh, J P, Lakka, T A, Gautvik, K M, Wilson, J F, Orwoll, E S, van Duijn, C M, Bønnelykke, K, Uitterlinden, A G, Styrkársdóttir, U, Akesson, K E, Spector, T D, Tobias, J H, Ohlsson, C, Felix, J F, Bisgaard, H, Grant, S F A, Richards, J B, Evans, D M, van der Eerden, B, van de Peppel, J, Ackert-Bicknell, C, Karasik, D, Kague, E & Rivadeneira, F 2023, ' Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis ', Communications Biology, vol. 6, no. 1, 691 . https://doi.org/10.1038/s42003-023-04869-0
Medina-Gomez, C, Mullin, B H, Chesi, A, Prijatelj, V, Kemp, J P, Shochat-Carvalho, C, Trajanoska, K, Wang, C, Joro, R, Evans, T E, Schraut, K E, Li-Gao, R, Ahluwalia, T S, Zillikens, M C, Zhu, K, Mook-Kanamori, D O, Evans, D S, Nethander, M, Knol, M J, Thorleifsson, G, Prokic, I, Zemel, B, Broer, L, McGuigan, F E, van Schoor, N M, Reppe, S, Pawlak, M A, Ralston, S H, van der Velde, N, Lorentzon, M, Stefansson, K, Adams, H H H, Wilson, S G, Ikram, M A, Walsh, J P, Lakka, T A, Gautvik, K M, Wilson, J F, Orwoll, E S, van Duijn, C M, Bønnelykke, K, Uitterlinden, A G, Styrkársdóttir, U, Akesson, K E, Spector, T D, Tobias, J H, Ohlsson, C, Felix, J F, Bisgaard, H, Grant, S F A, Richards, J B, Evans, D M, van der Eerden, B, van de Peppel, J, Ackert-Bicknell, C, Karasik, D, Kague, E & Rivadeneira, F 2023, ' Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis ', Communications biology, vol. 6, no. 1, pp. 691 . https://doi.org/10.1038/s42003-023-04869-0
Medina-Gomez, C, Mullin, B H, Chesi, A, Prijatelj, V, Kemp, J P, Shochat-Carvalho, C, Trajanoska, K, Wang, C, Joro, R, Evans, T E, Schraut, K E, Li-Gao, R, Ahluwalia, T S, Zillikens, M C, Zhu, K, Mook-Kanamori, D O, Evans, D S, Nethander, M, Knol, M J, Thorleifsson, G, Prokic, I, Zemel, B, Broer, L, McGuigan, F E, van Schoor, N M, Reppe, S, Pawlak, M A, Ralston, S H, van der Velde, N, Lorentzon, M, Stefansson, K, Adams, H H H, Wilson, S G, Ikram, M A, Walsh, J P, Lakka, T A, Gautvik, K M, Wilson, J F, Orwoll, E S, van Duijn, C M, Bønnelykke, K, Uitterlinden, A G, Styrkársdóttir, U, Akesson, K E, Spector, T D, Tobias, J H, Ohlsson, C, Felix, J F, Bisgaard, H, Grant, S F A, Richards, J B, Evans, D M, van der Eerden, B, van de Peppel, J, Ackert-Bicknell, C, Karasik, D, Kague, E & Rivadeneira, F 2023, ' Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis ', Communications biology, vol. 6, no. 1, pp. 691 . https://doi.org/10.1038/s42003-023-04869-0
Skull bone mineral density (SK-BMD) provides a suitable trait for the discovery of key genes in bone biology, particularly to intramembranous ossification, not captured at other skeletal sites. We perform a genome-wide association meta-analysis (n ~
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0210c01a3edbc01f4319030e3c622acd
https://curis.ku.dk/portal/da/publications/bone-mineral-density-loci-specific-to-the-skull-portray-potential-pleiotropic-effects-on-craniosynostosis(88c44e23-5a91-4fc4-9d6f-4630753c248f).html
https://curis.ku.dk/portal/da/publications/bone-mineral-density-loci-specific-to-the-skull-portray-potential-pleiotropic-effects-on-craniosynostosis(88c44e23-5a91-4fc4-9d6f-4630753c248f).html
Autor:
Alexander J. M. Dingemans, Kim M. G. Truijen, Sam van de Ven, Raphael Bernier, Ernie M. H. F. Bongers, Arjan Bouman, Laura de Graaff – Herder, Evan E. Eichler, Erica H. Gerkes, Christa M. De Geus, Johanna M. van Hagen, Philip R. Jansen, Jennifer Kerkhof, Anneke J. A. Kievit, Tjitske Kleefstra, Saskia M. Maas, Stella A. de Man, Haley McConkey, Wesley G. Patterson, Amy T. Dobson, Eloise J. Prijoles, Bekim Sadikovic, Raissa Relator, Roger E. Stevenson, Connie T. R. M. Stumpel, Malou Heijligers, Kyra E. Stuurman, Katharina Löhner, Shimriet Zeidler, Jennifer A. Lee, Amanda Lindy, Fanggeng Zou, Matthew L. Tedder, Lisenka E. L. M. Vissers, Bert B. A. de Vries
Publikováno v:
Translational psychiatry, 12(1):421
Dingemans, A J M, Truijen, K M G, van de Ven, S, Bernier, R, Bongers, E M H F, Bouman, A, de Graaff – Herder, L, Eichler, E E, Gerkes, E H, De Geus, C M, van Hagen, J M, Jansen, P R, Kerkhof, J, Kievit, A J A, Kleefstra, T, Maas, S M, de Man, S A, McConkey, H, Patterson, W G, Dobson, A T, Prijoles, E J, Sadikovic, B, Relator, R, Stevenson, R E, Stumpel, C T R M, Heijligers, M, Stuurman, K E, Löhner, K, Zeidler, S, Lee, J A, Lindy, A, Zou, F, Tedder, M L, Vissers, L E L M & de Vries, B B A 2022, ' The phenotypic spectrum and genotype-phenotype correlations in 106 patients with variants in major autism gene CHD8 ', Translational Psychiatry, vol. 12, 421, pp. 1-11 . https://doi.org/10.1038/s41398-022-02189-1
Translational Psychiatry, 12:421, 1-11. Nature Publishing Group
Translational Psychiatry, 12(1):421. Nature Publishing Group
Dingemans, A J M, Truijen, K M G, van de Ven, S, Bernier, R, Bongers, E M H F, Bouman, A, de Graaff – Herder, L, Eichler, E E, Gerkes, E H, de Geus, C M, van Hagen, J M, Jansen, P R, Kerkhof, J, Kievit, A J A, Kleefstra, T, Maas, S M, de Man, S A, McConkey, H, Patterson, W G, Dobson, A T, Prijoles, E J, Sadikovic, B, Relator, R, Stevenson, R E, Stumpel, C T R M, Heijligers, M, Stuurman, K E, Löhner, K, Zeidler, S, Lee, J A, Lindy, A, Zou, F, Tedder, M L, Vissers, L E L M & de Vries, B B A 2022, ' The phenotypic spectrum and genotype-phenotype correlations in 106 patients with variants in major autism gene CHD8 ', Translational psychiatry, vol. 12, no. 1, 421 . https://doi.org/10.1038/s41398-022-02189-1
Translational Psychiatry, 12, 1
Translational Psychiatry, 12
Translational psychiatry, 12(1):421. Nature Publishing Group
Dingemans, A J M, Truijen, K M G, van de Ven, S, Bernier, R, Bongers, E M H F, Bouman, A, de Graaff – Herder, L, Eichler, E E, Gerkes, E H, De Geus, C M, van Hagen, J M, Jansen, P R, Kerkhof, J, Kievit, A J A, Kleefstra, T, Maas, S M, de Man, S A, McConkey, H, Patterson, W G, Dobson, A T, Prijoles, E J, Sadikovic, B, Relator, R, Stevenson, R E, Stumpel, C T R M, Heijligers, M, Stuurman, K E, Löhner, K, Zeidler, S, Lee, J A, Lindy, A, Zou, F, Tedder, M L, Vissers, L E L M & de Vries, B B A 2022, ' The phenotypic spectrum and genotype-phenotype correlations in 106 patients with variants in major autism gene CHD8 ', Translational Psychiatry, vol. 12, 421, pp. 1-11 . https://doi.org/10.1038/s41398-022-02189-1
Translational Psychiatry, 12:421, 1-11. Nature Publishing Group
Translational Psychiatry, 12(1):421. Nature Publishing Group
Dingemans, A J M, Truijen, K M G, van de Ven, S, Bernier, R, Bongers, E M H F, Bouman, A, de Graaff – Herder, L, Eichler, E E, Gerkes, E H, de Geus, C M, van Hagen, J M, Jansen, P R, Kerkhof, J, Kievit, A J A, Kleefstra, T, Maas, S M, de Man, S A, McConkey, H, Patterson, W G, Dobson, A T, Prijoles, E J, Sadikovic, B, Relator, R, Stevenson, R E, Stumpel, C T R M, Heijligers, M, Stuurman, K E, Löhner, K, Zeidler, S, Lee, J A, Lindy, A, Zou, F, Tedder, M L, Vissers, L E L M & de Vries, B B A 2022, ' The phenotypic spectrum and genotype-phenotype correlations in 106 patients with variants in major autism gene CHD8 ', Translational psychiatry, vol. 12, no. 1, 421 . https://doi.org/10.1038/s41398-022-02189-1
Translational Psychiatry, 12, 1
Translational Psychiatry, 12
Translational psychiatry, 12(1):421. Nature Publishing Group
CHD8, a major autism gene, functions in chromatin remodelling and has various roles involving several biological pathways. Therefore, unsurprisingly, previous studies have shown that intellectual developmental disorder with autism and macrocephaly (I
Autor:
Leona Radmanić, Petra Korać, Lana Gorenec, Petra Šimičić, Kristian Bodulić, Adriana Vince, Snježana Židovec Lepej
Publikováno v:
Medicina; Volume 58; Issue 12; Pages: 1734
Background and Objectives: The aim of this study was to analyze the expression of genes on transcriptomic levels involved in inflammatory immune responses and the development of fibrosis in patients with chronic hepatitis C. Materials and Methods: Ex
Autor:
Vlad Cojocaru, Vikas Malik, Daisylyn Senna Tan, Mingxi Weng, Yogesh Srivastava, Lydia W.T. Cheung, Ralf Jauch, Guangming Wu, Asif Javed, Veeramohan Veerapandian
Publikováno v:
FEBS Journal, 287(1), 122-144. Wiley-Blackwell
The functional consequences of cancer-associated missense mutations are unclear for the majority of proteins. We have previously demonstrated that the activity of SOX and Pit-Oct-Unc (POU) family factors during pluripotency reprogramming can be switc