Transcription factor network dynamics during the commitment to oncogene-induced senescence

Autor: Themistoklis Vasilopoulos, Ricardo Iván Martínez-Zamudio

Publikováno v: Frontiers in Epigenetics and Epigenomics, Vol 2 (2024)

Aberrant oncogenic signaling causes cells to transition into oncogene-induced senescence (OIS) to limit uncontrolled proliferation. Despite being a potent tumor suppressor mechanism, OIS is an unstable cell state susceptible to reprogramming that can

Externí odkaz: https://doaj.org/article/673b6c2c15db47e78bed38ee23becd4a

Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication

Autor: Annette Feuchtinger, Gretchen Wolff, Bilgen Ekim Üstünel, Minako Sakurai, Anne Loft, Felix B. Pedersen, Kan Kau Chow, Peter P. Nawroth, Maria Troullinaki, Mauricio Berriel Diaz, Søren Fisker Schmidt, Mike Krogh Terkelsen, Stephan Herzig, Michele Puglia, Ana Jimena Alfaro, Riccardo Berutti, Blagoy Blagoev, Kim Ravnskjaer, Adriano Maida

Publikováno v: Loft, A, Alfaro, A J, Schmidt, S F, Pedersen, F B, Terkelsen, M K, Puglia, M, Chow, K K, Feuchtinger, A, Troullinaki, M, Maida, A, Wolff, G, Sakurai, M, Berutti, R, Üstünel, B E, Nawroth, P, Ravnskjaer, K, Diaz, M B, Blagoev, B & Herzig, S 2021, ' Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication ', Cell Metabolism, vol. 33, no. 8, pp. 1685-1700.e9 . https://doi.org/10.1016/j.cmet.2021.06.005
Cell Metab. 33, 1685-1700.e9 (2021)

Liver fibrosis is a strong predictor of long-term mortality in individuals with metabolic-associated fatty liver disease; yet, the mechanisms underlying the progression from the comparatively benign fatty liver state to advanced non-alcoholic steatoh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7183305586faeb771006a5f0b783ca33
https://portal.findresearcher.sdu.dk/da/publications/059a9be0-74d1-4a91-9d8c-e040db75bd2a

Single cell lineage analysis of mouse embryonic stem cells at the exit from pluripotency

Autor: Jamie Trott, Alfonso Martinez Arias

Publikováno v: Biology Open, Vol 2, Iss 10, Pp 1049-1056 (2013)

Summary Understanding how interactions between extracellular signalling pathways and transcription factor networks influence cellular decision making will be crucial for understanding mammalian embryogenesis and for generating specialised cell types

Externí odkaz: https://doaj.org/article/36ec692ad9d94be898393ffa1074fd14

A Novel GATA2 Protein Reporter Mouse Reveals Hematopoietic Progenitor Cell Types

Autor: Nouraiz, Ahmed, Leo, Kunz, Philipp S, Hoppe, Dirk, Loeffler, Martin, Etzrodt, Germán Camargo, Ortega, Oliver, Hilsenbeck, Konstantinos, Anastassiadis, Timm, Schroeder

Publikováno v: Stem Cell Reports

Summary The transcription factor (TF) GATA2 plays a key role in organ development and cell fate control in the central nervous, urogenital, respiratory, and reproductive systems, and in primitive and definitive hematopoiesis. Here, we generate a knoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::51a1328c783065f4fe81baa9bf235802
https://pubmed.ncbi.nlm.nih.gov/32649900

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