Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Transcription Elongation Factor SPT5"'
Autor:
Dan Spatt, Magdalena Murawska, James Chuang, Peter J. Park, Natalia I. Reim, Fred Winston, Dhawal Jain, L. Stirling Churchman, Francheska Lopez-Rivera, Olga V. Viktorovskaya
SUMMARYHistone chaperones are critical for controlling chromatin integrity during transcription, DNA replication, and DNA repair. We have discovered that the physical interaction between two essential histone chaperones, Spt6 and Spn1/Iws1, is requir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92bcbfb6d03df35cc647a3dc6164a989
https://doi.org/10.1101/2020.11.04.368589
https://doi.org/10.1101/2020.11.04.368589
Autor:
Tim-Michael Decker
Publikováno v:
Journal of molecular biology. 433(14)
The transcription elongation factor Spt5 is conserved from bacteria to humans. In eukaryotes, Spt5 forms a complex with Spt4 and regulates processive transcription elongation. Recent studies on transcription elongation suggest different mechanistic r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29cdd73a8db4cb850a9a24d2ca4295a1
https://pubmed.ncbi.nlm.nih.gov/32987031
https://pubmed.ncbi.nlm.nih.gov/32987031
Publikováno v:
RNA. 21:113-123
mRNA capping enzymes are directed to nascent RNA polymerase II (Pol2) transcripts via interactions with the carboxy-terminal domains (CTDs) of Pol2 and transcription elongation factor Spt5. Fission yeast RNA triphosphatase binds to the Spt5 CTD, comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06b246350f20207c864d56a1253beac
https://doi.org/10.1261/rna.048181.114
https://doi.org/10.1261/rna.048181.114
Publikováno v:
Molecular and Cellular Biology. 33:3259-3273
Transcription elongation factors associate with RNA polymerase II and aid its translocation through chromatin. One such factor is the conserved Paf1 complex (Paf1C), which regulates gene expression through several mechanisms, including the stimulatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1f0e856ae3f00696c6ad47fd33b7f95
https://doi.org/10.1128/mcb.00270-13
https://doi.org/10.1128/mcb.00270-13
Autor:
Ying Liu, Steven Hahn, Linda Warfield, Jie Luo, Jeffrey A. Ranish, Kevan M. Shokat, Walter H. Lang, Jasmina A. Allen, Chao Zhang
Publikováno v:
Molecular and Cellular Biology. 29:4852-4863
The Saccharomyces cerevisiae kinase Bur1 is involved in coupling transcription elongation to chromatin modification, but not all important Bur1 targets in the elongation complex are known. Using a chemical genetics strategy wherein Bur1 kinase was en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20cb76a18cb7ed1c36145231c429ae1
https://doi.org/10.1128/mcb.00609-09
https://doi.org/10.1128/mcb.00609-09
Protein phosphatases regulate mRNA synthesis and processing by remodeling the carboxy-terminal domain (CTD) of RNA polymerase II (Pol2) to dynamically inscribe a Pol2 CTD code. Fission yeast Fcp1 (SpFcp1) is an essential 723-amino acid CTD phosphatas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71bb70cf537586bb0c52e201ee87a969
https://europepmc.org/articles/PMC4436666/
https://europepmc.org/articles/PMC4436666/
Autor:
Mincheng Zhang, Kentaro Yamada, Jianhua Fu, Sheng Li, Yuichiro Takagi, Grant A. Hartzog, Peter A. Meyer
Publikováno v:
Molecular and cellular biology, vol 35, iss 19
The eukaryotic Spt4-Spt5 heterodimer forms a higher-order complex with RNA polymerase II (and I) to regulate transcription elongation. Extensive genetic and functional data have revealed diverse roles of Spt4-Spt5 in coupling elongation with chromati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffd79ca79716060ef34b918e60d90078
https://pubmed.ncbi.nlm.nih.gov/26217010
https://pubmed.ncbi.nlm.nih.gov/26217010
Publikováno v:
Genes & Development. 12:357-369
Previous characterization of the Saccharomyces cerevisiae Spt4, Spt5, and Spt6 proteins suggested that these proteins act as transcription factors that modify chromatin structure. In this work, we report new genetic and biochemical studies of Spt4, S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14776ae4ac4537f91543b9bd862f2464
https://doi.org/10.1101/gad.12.3.357
https://doi.org/10.1101/gad.12.3.357
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70184 (2013)
PLoS ONE
PLoS ONE
The early elongation checkpoint regulated by Positive Transcription Elongation Factor b (P-TEFb) is a critical control point for the expression of many genes. Spt5 interacts directly with RNA polymerase II and has an essential role in establishing th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e82f99e41fcabe5a65633635c0f0bf
http://europepmc.org/articles/PMC3718797?pdf=render
http://europepmc.org/articles/PMC3718797?pdf=render
Autor:
Masayasu Nomura, Yinfeng Zhang, Martha L. Sikes, Sarah L. French, Ann L. Beyer, Susan J. Anderson, Shilpa Salgia, David A. Schneider
Spt5p is a universally conserved transcription factor that plays multiple roles in eukaryotic transcription elongation. Spt5p forms a heterodimer with Spt4p and collaborates with other transcription factors to pause or promote RNA polymerase II trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::420600a5f3f571189e24c6d4beda3b19
https://europepmc.org/articles/PMC3099698/
https://europepmc.org/articles/PMC3099698/