Comparer des structures de gènes pour la prédiction de transcrits alternatifs codantschez l’humain, la souris et le chien

Autor: Guillaudeux, Nicolas

Publikováno v: Bio-Informatique, Biologie Systémique [q-bio.QM]. Université Rennes 1, 2021. Français

Living organisms are capable of expressing several alternative transcripts (or RNAs) from a single gene. These transcripts are responsible for the regulatory mechanisms of the organism, some of them are translated into protein. Today, detecting the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2755::d475c99b71125b16f0732f474cf34fd6
https://tel.archives-ouvertes.fr/tel-03540882

Evaluating approaches to find exon chains based on long reads

Autor: Anna Kuosmanen, Tuukka Norri, Veli Mäkinen

Publikováno v: Briefings in Bioinformatics

Transcript prediction can be modeled as a graph problem where exons are modeled as nodes and reads spanning two or more exons are modeled as exon chains. Pacific Biosciences third-generation sequencing technology produces significantly longer reads t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1d2d299f934317b4418618cf318c73
https://pubmed.ncbi.nlm.nih.gov/28069635

ASPicDB: A database web tool for alternative splicing analysis

Autor: D'Antonio, Mattia, Castrgnanò, Tiziana, Pallocca, Matteo, D'Erchia, Anna Maria, Picardi, Ernesto, Pesole, Graziano

Publikováno v: Methods in molecular biology (Clifton N.J.) 1269 (2015): 365–378. doi:10.1007/978-1-4939-2291-8_23
info:cnr-pdr/source/autori:D'Antonio, Mattia; Castrgnanò, Tiziana; Pallocca, Matteo; D'Erchia, Anna Maria; Picardi, Ernesto; Pesole, Graziano/titolo:ASPicDB: A database web tool for alternative splicing analysis/doi:10.1007%2F978-1-4939-2291-8_23/rivista:Methods in molecular biology (Clifton N.J.)/anno:2015/pagina_da:365/pagina_a:378/intervallo_pagine:365–378/volume:1269

Alternative splicing (AS) is a basic molecular phenomenon that increases the functional complexity of higher eukaryotic transcriptomes. Indeed, through AS individual gene loci can generate multiple RNAs from the same pre-mRNA. AS has been investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::6e108ee8a15182c2d05adea49ac2b5b0

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