Ανάλυση γονιδιακών ρυθμιστικών δικτύων που ενέχονται στην εμβρυική ανάπτυξη του παγκρέατος των θηλαστικών

Mammalian development occurs by the progressive determination of cells from a pluripotent undifferentiated state through successive states of gradually restricted developmental potential, until the full complement of mature terminally differentiated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::21f9c0dbba3def814c266b10d95e41e5
https://doi.org/10.12681/eadd/33068

Regulation of transcription factors via natural decoys in genomic DNA

Autor: Abhijnan Chattopadhyay, Catherine A. Kemme, Junji Iwahara, Dan Nguyen

Publikováno v: Transcription. 7:115-120

Eukaryotic genomic DNA contains numerous high-affinity sites for transcription factors. Only a small fraction of these sites directly regulates target genes. Other high-affinity sites can serve as naturally present decoys that sequester transcription

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee3ad96d352835a02decd86f4f32b9a
https://doi.org/10.1080/21541264.2016.1188873

Transcription factor trapping by RNA in gene regulatory elements

Autor: Alla A. Sigova, Brian J. Abraham, Xiong Ji, Benoit Molinie, Nancy M. Hannett, Yang Eric Guo, Mohini Jangi, Cosmas C. Giallourakis, Phillip A. Sharp, Richard A. Young

Publikováno v: Science. 350:978-981

Noncoding RNA helps protein binding Besides reading the coding regions of genes, RNA polymerase generates RNA at promoter-proximal and -distal DNA elements, but the function of these molecules is largely unknown. Sigova et al. show that these RNAs fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2268d6abbb3485032663d815c90f0a0
https://doi.org/10.1126/science.aad3346

Study of in vitro transcriptional binding effects and noise using constitutive promoters combined with UP element sequences in Escherichia coli

Autor: Qiang Yan, Stephen S. Fong

Publikováno v: Journal of Biological Engineering, Vol 11, Iss 1, Pp 1-11 (2017)
Journal of Biological Engineering

Background UP elements (upstream element) are DNA sequences upstream of a promoter that interact with the α-subunit of RNA polymerase (RNAP) and can affect transcription by altering the binding RNAP to DNA. However, details of UP element and binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ab22b5042403a9a211c37c6a92a39b
https://doi.org/10.1186/s13036-017-0075-2

Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells

Autor: Stefan Schoenfelder, Mikhail Spivakov, Mayra Furlan-Magaril, Peter Fraser, Steven W. Wingett, Paula Freire-Pritchett, Csilla Várnai, Cameron S. Osborne, Peter J. Rugg-Gunn, Raquel García-Vílchez, Jonathan Cairns, Amanda J. Collier

Publikováno v: Freire-Pritchett, P, Schoenfelder, S, Várnai, C, Wingett, S W, Cairns, J, Collier, A J, García-Vílchez, R, Furlan-Magaril, M, Osborne, C, Fraser, P, Rugg-Gunn, P J & Spivakov, M 2017, ' Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells ', eLife, vol. 6, e21926 . https://doi.org/10.7554/eLife.21926
eLife, Vol 6 (2017)
eLife

Long-range cis-regulatory elements such as enhancers coordinate cell-specific transcriptional programmes by engaging in DNA looping interactions with target promoters. Deciphering the interplay between the promoter connectivity and activity of cis-re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::921cb91257793a9281f26be7341f8c2d
https://kclpure.kcl.ac.uk/ws/files/115265823/Global_reorganisation_of_cis_PRITCHETT_Accepted_22_March_2017_GOLD_VoR_CC_BY_.pdf