A SAGA-independent function of SPT3 mediates transcriptional deregulation in a mutant of the Ccr4-not complex in Saccharomyces cerevisiae

Autor: Martine A. Collart, Nicole James, Emilie Landrieux

Publikováno v: Genetics, Vol. 177, No 1 (2007) pp. 123-35

The conserved multi-subunit Ccr4-Not complex regulates gene expression in diverse ways. In this work, we characterize the suppression of temperature sensitivity associated with a mutation in the gene encoding the scaffold subunit of the Ccr4-Not comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec48d9ca0366a224aa4ba8934bcbf349
https://pubmed.ncbi.nlm.nih.gov/17660549

Aging correlates with decreased beta-cell proliferative capacity and enhanced sensitivity to apoptosis: a potential role for Fas and pancreatic duodenal homeobox-1

Autor: Maedler, Kathrin, Schumann, Desiree, Schulthess, Fabienne, Oberholzer, José, Bosco, Domenico, Berney, Thierry, Donath, Marc Y

Publikováno v: Diabetes, Vol. 55, No 9 (2006) pp. 2455-62

Type 2 diabetes is characterized by a deficit in beta-cell mass, and its incidence increases with age. Here, we analyzed beta-cell turnover in islets from 2- to 3- compared with 7- to 8-month-old rats and in human islets from 53 organ donors with age

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1400::2cf7ee5e4e4ea12f8b72a0f4a6f1ba72
https://archive-ouverte.unige.ch/unige:36975

Smooth muscle cell: a key cell for plaque vulnerability regulation?

Autor: Marie-Luce Bochaton-Piallat, Giulio Gabbiani

Publikováno v: Circulation Research, Vol. 98, No 4 (2006) pp. 448-449

See related article, pages 472–479 The concept that the atheromatous plaque undergoes a complex inflammatory and fibroproliferative process, which is likely responsible for the onset of complications,1 and the notion of vulnerable plaque2 have acqu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b16eaa402f19bf0169afac25e5bdcc63
https://archive-ouverte.unige.ch/unige:11161

A functional polymorphism in a STAT5B site of the human PPAR gamma 3 gene promoter affects height and lipid metabolism in a French population

Autor: Philippe Amouyel, Fabrice Gouilleux, Lluis Fajas, Johan Auwerx, Nicole Helbecque, Aline Meirhaeghe, Dominique Cottel

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology
Arteriosclerosis, Thrombosis, and Vascular Biology, 2003, 23 (2), pp.289-294. ⟨10.1161/01.atv.0000051382.28752.fe⟩
Arteriosclerosis, Thrombosis, and Vascular Biology, American Heart Association, 2003, 23 (2), pp.289-294. ⟨10.1161/01.atv.0000051382.28752.fe⟩

Objective— The peroxisome proliferator-activated receptor-γ (PPARγ) plays a role in adipocyte differentiation and insulin sensitization. It has been shown that genetic variation in the PPARγ gene alters body weight control, lipid and insulin hom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33057e4a9e30d321bbfaf72fd2dab945
https://pubmed.ncbi.nlm.nih.gov/12588773

VE-cadherin-induced Cdc42 signaling regulates formation of membrane protrusions in endothelial cells

Autor: Maria Konstantoulaki, Asrar B. Malik, Panos Kouklis

The cytoplasmic domain of cadherins and the associated catenins link the cytoskeleton with signal transduction pathways. To study the signaling function of non-junctional VE-cadherin, which can form during the loss VE-cadherin homotypic adhesion, wil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::869b814c7723dbc556d99063610f2707
http://olympias.lib.uoi.gr/jspui/handle/123456789/18177