Cbx4 regulates the proliferation of thymic epithelial cells and thymus function

Autor: Liu, B., Liu, Y. F., Du, Y. R., Mardaryev, A. N., Yang, W., Chen, H., Xu, Z. M., Xu, C. Q., Zhang, X. R., Botchkarev, V. A., Zhang, Y., Xu, G. L.

Thymic epithelial cells (TECs) are the main component of the thymic stroma, which supports T-cell proliferation and repertoire selection. Here, we demonstrate that Cbx4, a Polycomb protein that is highly expressed in the thymic epithelium, has an ess

Externí odkaz: http://hdl.handle.net/10454/6068

Pioneering Activity of the C-Terminal Domain of EBF1 Shapes the Chromatin Landscape for B Cell Programming

Autor: Rudolf Grosschedl, Duygu Akbas, Dirk Schübeler, Robert Nechanitzky, Rabih Murr, Senthilkumar Ramamoorthy, Sören Boller, Lukas Burger

Publikováno v: Immunity
Immunity, Vol. 44, No 3 (2016) pp. 527-541

Lymphopoiesis requires the activation of lineage-specific genes embedded in naive, inaccessible chromatin or in primed, accessible chromatin. The mechanisms responsible for de novo gain of chromatin accessibility, known as "pioneer" function, remain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c23e9cb7044ab1cf64d6d8b293541ad

The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin

Autor: Galvan, Laurie, Francelle, Laetitia, Gaillard, Marie-Claude, De Longprez, Lucie, Carrillo-de Sauvage, Maria-Angeles, Liot, Géraldine, Cambon, Karine, Stimmer, Lev, Luccantoni, Sophie, Flament, Julien, Valette, Julien, De Chaldée, Michel, Auregan, Gwenaëlle, Guillermier, Martine, Joséphine, Charlène, Petit, Fanny, Jan, Caroline, Jarrige, Margot, Dufour, Noëlle, Bonvento, Gilles, Humbert, Sandrine, Saudou, Frédéric, Hantraye, Philippe, Mérienne, Karine, Bemelmans, Alexis-Pierre, Perrier, Anselme, Déglon, Nicole, Brouillet, Emmanuel

Publikováno v: Brain-A Journal of Neurology
Brain-A Journal of Neurology, Oxford University Press (OUP), 2018, 141 (5), pp.1434-1454. ⟨10.1093/brain/awy057⟩
Brain-A Journal of Neurology, 2018, 141 (5), pp.1434-1454. ⟨10.1093/brain/awy057⟩
Brain
Brain, vol. 141, no. 5, pp. 1434-1454

Expression of the neuronal kinase DCLK3 is reduced in Huntington’s disease. Galvan et al. report that DCLK3 silencing in the mouse striatum exacerbates the toxicity of mutant huntingtin, whereas DCLK3 overexpression is neuroprotective, and show tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::eb0c82958019d7f33356d092f6de6863
https://hal.archives-ouvertes.fr/hal-02459743

REST represses a subset of the pancreatic endocrine differentiation program

Autor: Yung Hae Kim, Jacques-Antoine Haefliger, Chai An Mao, Anne Grapin-Botton, David Martin, Dror Sever

Publikováno v: Developmental Biology, vol. 405, no. 2, pp. 316-327
Developmental biology

To contribute to devise successful beta-cell differentiation strategies for the cure of Type 1 diabetes we sought to uncover barriers that restrict endocrine fate acquisition by studying the role of the transcriptional repressor REST in the developin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11b56bf5e0c72b260fda4d146f46f850

Glucagon-Like Peptide-1 Triggers Protective Pathways in Pancreatic Beta-Cells Exposed to Glycated Serum

Autor: François Mach, Roberta Sanguineti, Alessandra Puddu, Giorgio Luciano Viviani, Fabrizio Montecucco, Alessio Nencioni, Arianna Durante

Publikováno v: Mediators of Inflammation, Vol. 2013 (2013) P. 317120
Mediators of Inflammation
Mediators of Inflammation, Vol 2013 (2013)

Advanced glycation end products (AGEs) might play a pathophysiological role in the development of diabetes and its complications. AGEs negatively affect pancreatic beta-cell function and the expression of transcriptional factors regulating insulin ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e81936c2739939c2843eb8a253f1e9
https://doi.org/10.1155/2013/317120