Výsledky vyhledávání - "Trans-Activators/*chemistry"

CpG islands influence chromatin structure via the CpG-binding protein Cfp1

Autor: Robert S. Illingworth, Shaun Webb, Adrian Bird, Jim Selfridge, Alastair R.W. Kerr, Aimee M. Deaton, Thomas Clouaire, Robert Andrews, John P. Thomson, Daniel J. Turner, Keith D. James, Peter J Skene, Jacky Guy

Publikováno v: Thomson, J P, Skene, P J, Selfridge, J, Clouaire, T, Guy, J, Webb, S, Kerr, A R W, Deaton, A, Andrews, R, James, K D, Turner, D J, Illingworth, R & Bird, A 2010, ' CpG islands influence chromatin structure via the CpG-binding protein Cfp1 ', Nature, vol. 464, no. 7291, pp. 1082-1086 . https://doi.org/10.1038/nature08924

CpG islands (CGIs) are prominent in the mammalian genome owing to their GC-rich base composition and high density of CpG dinucleotides1,2. Most human gene promoters are embedded within CGIs that lack DNA methylation and coincide with sites of histone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7ea45c2d917f67d025d494d1520a3c
https://doi.org/10.1038/nature08924

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Inhibiting fungal multidrug resistance by disrupting an activator-Mediator interaction

Autor: Joy L. Nishikawa, Dominique Sanglard, Anders M. Näär, Riccardo Torelli, Luís A. Vale-Silva, Maurizio Sanguinetti, Brunella Posteraro, Haribabu Arthanari, Andras Boeszoermenyi, Ruslan I. Sadreyev, Jayaram Bhyravabhotla, Goutam Dev Mukherjee, Gerhard Wagner, Fei Ji, Sara J. Buhrlage, Nathanael S. Gray, Yoo-Jin Sohn, Vladimir Gelev

Publikováno v: Nature
Europe PubMed Central
Nature, vol. 530, no. 7591, pp. 485-489

Eukaryotic transcription activators stimulate the expression of specific sets of target genes through recruitment of co-activators such as the RNA polymerase II-interacting Mediator complex. Aberrant function of transcription activators has been impl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::387b05bb85fa8b6fb9b167c377f136ee
http://hdl.handle.net/10807/72311

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Positive Selection of Mutations Leading to Loss or Reduction of Transcriptional Activity of PrfA, the Central Regulator ofListeria monocytogenesVirulence

Autor: M Herler, Yolanda Vega, A Bubert, Werner Goebel, Monika Goetz, José A. Vázquez-Boland

Publikováno v: Herler, M, Bubert, A, Goetz, M, Vega, Y, Vazquez-Boland, J A & Goebel, W 2001, ' Positive selection of mutations leading to loss or reduction of transcriptional activity of PrfA, the central regulator of Listeria monocytogenes virulence ', Journal of Bacteriology, vol. 183, no. 19, pp. 5562-70 . https://doi.org/10.1128/JB.183.19.5562-5570.2001

Transcription factor PrfA controls the expression of virulence genes essential forListeria monocytogenespathogenesis. To gain insight into the structure-function relationship of PrfA, we devised a positive-selection system to isolate mutations reduci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b0f32074aaebc39310fab8069098eee
https://doi.org/10.1128/jb.183.19.5562-5570.2001

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A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients

Autor: Bernard Conrad, Denis F. Hochstrasser, Walter Reith, Bernard Mach, Krzysztof Masternak, Garry L. Corthals, Jean-Charles Sanchez, Madeleine Zufferey, Emmanuèle Barras, Ruedi Aebersold

Publikováno v: Nature Genetics, Vol. 20, No 3 (1998) pp. 273-277

Major histocompatibility class II (MHC-II) molecules are transmembrane proteins that have a central role in development and control of the immune system. They are encoded by a multigene family and their expression is tightly regulated. MHC-II deficie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27fa563bfc2c65bbb4fa596b5917ca86
https://doi.org/10.1038/3081

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Characterisation of the putative effector interaction site of the regulatory HbpR protein from Pseudomonas azelaica by site-directed mutagenesis

Autor: Jan Roelof van der Meer, Rup Lal, Christelle Vogne, Sagrario Arias, Hansi Bisht, Sofía Fraile

Publikováno v: PLoS One, vol. 6, no. 2, pp. e16539
PLoS ONE
PLoS ONE, Vol 6, Iss 2, p e16539 (2011)

Bacterial transcription activators of the XylR/DmpR subfamily exert their expression control via σ(54)-dependent RNA polymerase upon stimulation by a chemical effector, typically an aromatic compound. Where the chemical effector interacts with the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796b9fcccf2357ac88cba3313b896b47
https://serval.unil.ch/notice/serval:BIB_EB607C562CAB

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Mutant HbpR transcription activator isolation for 2-chlorobiphenyl via green fluorescent protein-based flow cytometry and cell sorting

Autor: Beggah, Siham, Vogne, Christelle, Zenaro, Elena, Van Der Meer, Jan Roelof

Publikováno v: Microbial Biotechnology, vol. 1, no. 1, pp. 68-78
Microbial Biotechnology

Summary Mutants were produced in the A‐domain of HbpR, a protein belonging to the XylR family of σ54‐dependent transcription activators, with the purpose of changing its effector recognition specificity from 2‐hydroxybiphenyl (2‐HBP, the cog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2f47a552516a53f2bcc096608ad1fb15
https://hdl.handle.net/11562/335319

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New functions of the major histocompatibility complex class II-specific transcription factor RFXANK revealed by a high-resolution mutagenesis study

Autor: Emmanuèle Barras, Walter Reith, Madeleine Zufferey, Michal Krawczyk, Krzysztof Masternak

Publikováno v: Molecular and Cellular Biology, Vol. 25, No 19 (2005) pp. 8607-8618

The transcription factors RFX and CIITA are major players in regulation of the expression of all classical and nonclassical major histocompatibility complex class II (MHC-II) genes. RFX nucleates the formation of a multiprotein complex, called the MH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c02ca9c7733e753201efa83acf4cc818
https://pubmed.ncbi.nlm.nih.gov/16166641

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Expression of clock gene in the brain of rainbow trout: comparison with the distribution of melatonin receptors

Autor: Isabelle Anglade, Ian Brierley, D. Mazurais, G Le Drean, Olivier Kah, Lynda Williams, Niall Bromage

Publikováno v: Journal of Comparative Neurology
Journal of Comparative Neurology, Wiley, 2000, 422 (4), pp.612-620. ⟨10.1002/1096-9861(20000710)422:43.0.CO;2-Y⟩
Journal of Comparative Neurology, 2000, 422 (4), pp.612-620. ⟨10.1002/1096-9861(20000710)422:43.0.CO;2-Y⟩

International audience; To identify brain structures potentially acting as biological clocks in rainbow trout (Oncorhynchus mykiss), the expression sites of a trout homolog of the mouse clock gene were studied and compared with that of melatonin rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88680a79879eb1ec8b56457310a9a5d0
https://hal.inrae.fr/hal-02698790

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Differential activation of STATs 3 and 5 during mammary gland development

Autor: Thomas G. Burdon, Christine J. Watson, Janet A.C. Philp

Publikováno v: Philp, J A C, Burdon, T & Watson, C J 1996, ' Differential activation of STATs 3 and 5 during mammary gland development ', FEBS Letters, vol. 396, no. 1, pp. 77-80 . https://doi.org/10.1016/0014-5793(96)01069-1

We have investigated the activity of STAT family members throughout a mammary developmental cycle. Transcripts for Stat 5 were upregulated during pregnancy whilst STAT1 and STAT3 mRNAs were expressed at constant levels. DNA binding complexes containi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde00ac6a77467eaec37fffca0cb2ea7
https://pubmed.ncbi.nlm.nih.gov/8906870

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