Zobrazeno 1 - 10
of 472
pro vyhledávání: '"Trans signaling"'
Autor:
Ian G. Gober, Ashley L. Russell, Tyler J. Shick, Vincent A. Vagni, Jenna C. Carlson, Patrick M. Kochanek, Amy K. Wagner
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-12 (2024)
Abstract Uncontrolled neuroinflammation mediates traumatic brain injury (TBI) pathology and impairs recovery. Interleukin-6 (IL-6), a pleiotropic inflammatory regulator, is associated with poor clinical TBI outcomes. IL-6 operates via classical-signa
Externí odkaz:
https://doaj.org/article/203db4b4abdf484d8c8eb4b1304705c9
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundMany cancers metastasize to the pleura, resulting in effusions that cause dyspnea and discomfort. Regardless of the tissue of origin, pleural malignancies are aggressive and uniformly fatal, with no treatment shown to prolong life. The pleu
Externí odkaz:
https://doaj.org/article/41910254bf454a3fbd96114ec57e262c
Autor:
Alessia Maria Cossu, Federica Melisi, Teresa Maria Rosaria Noviello, Lucia Stefania Pasquale, Piera Grisolia, Carla Reale, Marco Bocchetti, Michela Falco, Chiara Tammaro, Nunzio Accardo, Francesco Longo, Salvatore Allosso, Massimo Mesolella, Raffaele Addeo, Francesco Perri, Alessandro Ottaiano, Filippo Ricciardiello, Evzen Amler, Concetta Ambrosino, Gabriella Misso, Michele Ceccarelli, Michele Caraglia, Marianna Scrima
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 1, Pp 102140- (2024)
MicroRNAs (miRNAs) are involved in post-transcriptional gene expression regulation and in mechanisms of cancer growth and metastases. In this light, miRNAs could be promising therapeutic targets and biomarkers in clinical practice. Therefore, we inve
Externí odkaz:
https://doaj.org/article/d6b96f056ecb41df998974deaab3436d
Publikováno v:
Bangladesh Journal of Pharmacology, Vol 18, Iss 4 (2023)
The present study was conducted to investigate the therapeutic efficacy of CYT387 in rheumatoid arthritis pathogenesis concerning T helper 17 cell/regulatory T cell (Th17/Treg) imbalance and osteoclastogenesis. In this study, CYT 387 inhibited the pr
Externí odkaz:
https://doaj.org/article/da521fec68b946a4ae60a9274026d128
Autor:
Stephan A. Müller, Merav D. Shmueli, Xiao Feng, Johanna Tüshaus, Neele Schumacher, Ryan Clark, Brad E. Smith, An Chi, Stefan Rose-John, Matthew E. Kennedy, Stefan F. Lichtenthaler
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-20 (2023)
Abstract Background The protease BACE1 is a major drug target for Alzheimer’s disease, but chronic BACE1 inhibition is associated with non-progressive cognitive worsening that may be caused by modulation of unknown physiological BACE1 substrates. M
Externí odkaz:
https://doaj.org/article/7fa094553b0842b2823d05e839ed3787
Publikováno v:
Jichu yixue yu linchuang, Vol 42, Iss 12, Pp 1895-1899 (2022)
Objective To investigate effects of IL-6 trans-signaling on immuno-inflammatory regulation in cecum ligation and puncture (CLP)-induced mice with sepsis. Methods Eighty mice were divided randomly into four groups: sham group (n=15), CLP group (n=30),
Externí odkaz:
https://doaj.org/article/0d4161fd24974c6e8a4eb7e69ed0abd1
Akademický článek
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Akademický článek
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Akademický článek
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Autor:
Odmara L. Barreto Chang, Mervyn Maze
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2023)
For most, staying “mentally sharp” as they age is a very high priority that may be thwarted by the consequences of a postoperative complication unrelated to the disorder which necessitated the surgical intervention. Perioperative neurocognitive d
Externí odkaz:
https://doaj.org/article/545d24575b1244a49fd9d34ba29d56cd