Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Tran Chinh Viet"'
Autor:
Haleigh Howard, Eric Sung, Samuel Sperry, Christopher J. Wegerski, Tran Chinh Viet, Adina Gerson-Gurwitz, Gary G. Chiang, Garrick Packard, Andres Nevarez, Paul A. Sprengeler, Joan Chen, Jocelyn Staunton, Kevin R. Webster, Maria Barrera, Reich Siegfried Heinz, Ana Parra, Nathan P Young, Alan Xiang, Justin T. Ernst, Sarah Fish, Theodore Michels, Peggy A. Thompson, Christian Nilewski, Jeff Clarine, Boreth Eam
Publikováno v:
Molecular Cancer Therapeutics. 20:26-36
The PI3K/AKT/mTOR pathway is often activated in lymphoma through alterations in PI3K, PTEN, and B-cell receptor signaling, leading to dysregulation of eIF4A (through its regulators, eIF4B, eIF4G, and PDCD4) and the eIF4F complex. Activation of eIF4F
Autor:
Cheng Y. Yang, Cottell Jeromy J, Krygowski Evan S, Jason K. Perry, Katana Ashley Anne, Mei Yu, Yujin Wang, Tran Chinh Viet, Guangyu Zhao, Yang Zheng-Yu, Kelly Wang, Yu-Jen Lee, Ruoyu Gong, Eric M. Gorman, Alejandra Trejo-Martin, Yang Tian, Kato Darryl, Erik Mogalian, Bacon Elizabeth M, Link John O, James G. Taylor, Guofeng Cheng, Zipfel Sheila
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2415-2427
Direct-acting antiviral inhibitors have revolutionized the treatment of hepatitis C virus (HCV) infected patients. Herein is described the discovery of velpatasvir (VEL, GS-5816), a potent pan-genotypic HCV NS5A inhibitor that is a component of the o
Autor:
Kyla Ramey, Katana Ashley Anne, Kato Darryl, Tran Chinh Viet, Cheng Y. Yang, Link John O, Debi Jin, Yujin Wang, Kobayashi Tetsuya, Karki Kapil Kumar, Armando G. Villaseñor, Todd C. Appleby, Kelly Wang, Sangi Michael, Jeff Zablocki, Randy Vivian, Brian E. Schultz, Yang Zheng-Yu, Guofeng Cheng, Dustin Siegel, Zipfel Sheila, Ona Barauskas, James G. Taylor, Martinez Ruben, Katie Chan, Adam J. Schrier
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2428-2436
Treatment of hepatitis C virus (HCV) infection has been historically challenging due the high viral genetic complexity wherein there are eight distinct genotypes and at least 86 viral subtypes. While HCV NS3/4A protease inhibitors are an established
Autor:
Nathan P Young, Paul A. Sprengeler, Christopher J. Wegerski, Samuel Sperry, Tran Chinh Viet, Andres Nevarez, Kevin R. Webster, Jocelyn Staunton, Haleigh Howard, Gary G. Chiang, Jim R Appleman, Alan Xiang, Theodore Michels, Reich Siegfried Heinz, Jolene Molter, Garrick Packard, Jeff Clarine, Christian Nilewski, Sarah Fish, Justin T. Ernst, Peggy A. Thompson, Boreth Eam, Joan Chen
Publikováno v:
Journal of medicinal chemistry. 63(11)
Dysregulation of protein translation is a key driver for the pathogenesis of many cancers. Eukaryotic initiation factor 4A (eIF4A), an ATP-dependent DEAD-box RNA helicase, is a critical component of the eIF4F complex, which regulates cap-dependent pr
Autor:
Nathan P. Young, Gary G. Chiang, Andres Nevarez, Joan Chen, Tran Chinh Viet, Reich Siegfried Heinz, Theodore Michels, Eric Sung, Haleigh Howard, Christopher J. Wegerski, Ana Parra, Gregory S. Parker, Boreth Eam, Alan Xiang, Samuel Sperry, Jocelyn Staunton, Maria Barrera, Christian Nilewski, Kevin R. Webster, Garrick Packard, Sarah Fish, Jeff Clarine, Paul A. Sprengeler, Peggy A. Thompson, Ivy Nj Hung, Justin T. Ernst
Publikováno v:
Cancer Research. 78:DDT02-05
eFT226: A Selective and Highly Potent Inhibitor of Eukaryotic Initiation Factor 4A (eIF4A), a Novel Approach for the Treatment of Cancer Siegfried H Reich, Peggy A Thompson, Justin T Ernst, Boreth Eam, Nathan P Young, Sarah Fish, Joan Chen, Maria Bar
Autor:
Joan Chen, Melissa Neal, Katti Jessen, Gregory S. Parker, Reich Siegfried Heinz, Michael B. Shaghafi, Edward Z. R. Han, Ivy Nj Hung, Justin T. Ernst, James R. Appleman, Tran Chinh Viet, Qing Han, Douglas E. Murphy, Craig R. Stumpf, Christopher J. Wegerski, Vera Huang, Jolene Molter, Paul A. Sprengeler, Peggy A. Thompson, Jocelyn Staunton, Gary G. Chiang, Vikas K Goel, Jeff Clarine, Samuel Sperry, Boreth Eam, Kevin R. Webster, Adriana L. Jemison, Stephen E. Webber, Hong Zheng
Publikováno v:
Journal of medicinal chemistry. 61(8)
Dysregulated translation of mRNA plays a major role in tumorigenesis. Mitogen-activated protein kinase interacting kinases (MNK)1/2 are key regulators of mRNA translation integrating signals from oncogenic and immune signaling pathways through phosph
Autor:
Christian Nilewski, Tran Chinh Viet, Jeff Clarine, Eric Sung, Christopher J. Wegerski, Andres Nevarez, Gary G. Chiang, Maria Barrera, Jocelyn Staunton, Haleigh Howard, Peggy A. Thompson, Alan Xiang, Paul A. Sprengeler, Theodore Michels, Samuel Sperry, Ana Parra, Justin T. Ernst, Boreth Eam, Sarah Fish, Nathan P. Young, Kevin R. Webster, Garrick Packard, Reich Siegfried Heinz, Joan Chen
Publikováno v:
Cancer Research. 79:2698-2698
Dysregulated messenger RNA (mRNA) translation drives the pathogenesis of multiple hematological malignancies. In lymphoma this includes the upregulation of key driver oncogenes and anti-apoptotic proteins (e.g., MYC, CCND1/3, BCL2 and MCL1) that cont
Autor:
Alan X. Xiang, Tran Chinh Viet, Douglas E. Murphy, Yuefen Zhou, Frank Ruebsam, Sun Hee Kim, Kimkim Dao, Lian-Sheng Li, Zhongxiang Sun, Peter S. Dragovich
Publikováno v:
Tetrahedron: Asymmetry. 19:2796-2803
A 4-step synthesis of an optically active synthetic intermediate [(1 R ,2 S )-2-(4′-fluorobenzylamino)cyclopentanecarboxylic acid ethyl ester complex with ( S )-(+)-mandelic acid; compound 12 , >99% de] required for the preparation of a promising H
Autor:
Laurie A. LeBrun, Mei Tsan, Yuefen Zhou, Frank Ruebsam, Darian M. Bartkowski, Alan X. Xiang, Ruhi Kamran, Lian-Sheng Li, Richard E. Showalter, Jingjing Zhao, Rupal Patel, Matthew Lardy, Maria V. Sergeeva, Stephen E. Webber, Amit M. Shah, David Archer Ellis, Zhongxiang Sun, Mcguire Helen, Julie Blazel, Leo Kirkovsky, Daniel A. Norris, Tran Chinh Viet, Charles R. Kissinger, Thomas G. Nolan, Peter S. Dragovich, Qing Han
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4628-4632
4-(1,1-Dioxo-1,4-dihydro-1lambda(6)-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-one analogs were discovered as a novel class of inhibitors of HCV NS5B polymerase. Structure-based design led to the identification of compound 3a that displayed pot
Autor:
Tran Chinh Viet, Charles R. Kissinger, Daniel A. Norris, Ruhi Kamran, Amit M. Shah, Jingjing Zhao, Yuefen Zhou, Rupal Patel, Matthew Lardy, Darian M. Bartkowski, Richard E. Showalter, Stephen E. Webber, Laurie A. LeBrun, Mei Tsan, Douglas E. Murphy, Sun Hee Kim, Maria V. Sergeeva, Leo Kirkovsky, Martin T. Tran, Thomas G. Nolan, Qing Han, Frank Ruebsam, Lian-Sheng Li, Peter S. Dragovich
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3616-3621
Pyrrolo[1,2-b]pyridazin-2-one analogs were discovered as a novel class of inhibitors of genotype 1 HCV NS5B polymerase. Structure-based design led to the discovery of compound 3 k, which displayed potent inhibitory activities in biochemical and repli