RNA binding protein IGF2BP1 synergizes with ETV6-RUNX1 to drive oncogenic signaling in B-cell Acute Lymphoblastic Leukemia.

Autor: Sharma, Gunjan¹ (AUTHOR), Tran, Tiffany M.² (AUTHOR), Bansal, Ishu¹ (AUTHOR), Beg, Mohammad Sabique¹ (AUTHOR), Bhardwaj, Ruchi¹ (AUTHOR), Bassi, Jaspal² (AUTHOR), Tan, Yuande³ (AUTHOR), Jaiswal, Amit Kumar² (AUTHOR), Tso, Christine² (AUTHOR), Jain, Ayushi¹ (AUTHOR), Singh, Jay⁴ (AUTHOR), Chattopadhyay, Parthaprasad¹ (AUTHOR), Singh, Archna¹ (AUTHOR), Chopra, Anita⁴ (AUTHOR), Bakhshi, Sameer⁵ (AUTHOR), Casero, David³ (AUTHOR), Rao, Dinesh S.² (AUTHOR), Palanichamy, Jayanth Kumar¹ (AUTHOR) drjayanth@aiims.edu

Publikováno v: Journal of Experimental & Clinical Cancer Research (17569966). 9/5/2023, Vol. 42 Issue 1, p1-20. 20p.

RNA binding proteins in MLL-rearranged leukemia.

Autor: Tran, Tiffany M.^1,2 (AUTHOR), Rao, Dinesh S.^1,3,4 (AUTHOR) DRao@mednet.ucla.edu

Publikováno v: Experimental Hematology & Oncology. 10/28/2022, Vol. 11 Issue 1, p1-19. 19p.

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Post-transcriptional gene regulation by the RNA binding protein IGF2BP3 is critical for MLL-AF4 mediated leukemogenesis

Autor: Tran, Tiffany M, Philipp, Julia, Bassi, Jaspal, Nibber, Neha, Draper, Jolene, Lin, Tasha, Palanichamy, Jayanth Kumar, Jaiswal, Amit Kumar, Silva, Oscar, Paing, May, King, Jennifer, Katzman, Sol, Sanford, Jeremy R, Rao, Dinesh S

Despite recent advances in therapeutic approaches, patients with MLL-rearranged leukemia still have poor outcomes and a high risk of relapse. Here, we found that MLL-AF4, the most common MLL fusion protein in patients, transcriptionally induces IGF2B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6eaa04c0365c0aa92c68079d4b63b319
https://escholarship.org/uc/item/27m6k315