Výsledky vyhledávání - "Tran, N. Pham"

MAS NMR Investigation of Molecular Order in an Ionic Liquid Crystal

Autor: Jeraime Griffith, Steven Huband, Chi Long Chan, Tran N. Pham, Nicholas J. Brooks, David Pugh, Józef R. Lewandowski, Steven P. Brown, Lisa L. McQueen, Sarah K. Mann, Tom Welton, Mohit K. Devgan, W. Trent Franks

Publikováno v: The Journal of Physical Chemistry. B

The structure and molecular order in the thermotropic ionic liquid crystal (ILC), [choline][geranate(H)octanoate], an analogue of Choline And GEranate (CAGE), which has potential for use as a broad-spectrum antimicrobial and transdermal and oral deli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23408c6ac64e66eb46370f15a3b20767
https://doi.org/10.1021/acs.jpcb.0c02328

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Local Structural Effects Due to Micronization and Amorphization on an HIV Treatment Active Pharmaceutical Ingredient

Autor: Dewey H. Barich, Matthew D. Burke, Tran N. Pham, Maxwell W. Terban, Simon J. L. Billinge, Jeffrey Brum, Yan T. Sun, Luca Russo

Publikováno v: Molecular pharmaceutics. 17(7)

Processing procedures for inducing domain size reduction and/or amorphous phase generation can be crucial for enhancing the bioavailability of active pharmaceutical ingredients (APIs). It is important to quantify these reduced coherence phases and to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d20b33c4ee3c58a1445145b907022f2a
https://pubmed.ncbi.nlm.nih.gov/32293895

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Revealing intermolecular hydrogen bonding structure and dynamics in a deep eutectic pharmaceutical by magic-angle spinning NMR spectroscopy

Autor: Lisa L. McQueen, Steven P. Brown, Sarah K. Mann, Tran N. Pham, Józef R. Lewandowski

Publikováno v: Molecular Pharmaceutics

Liquid forms of pharmaceuticals (ionic liquids and deep eutectic solvents) offer a number of potential advantages over solid-state drugs; a key question is the role of intermolecular hydrogen bonding interactions in enabling membrane transport. Chara

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724ed9c9b8e52bfecf26dce761aa2e93
http://wrap.warwick.ac.uk/131729/1/WRAP-revealing-intermolecular-hydrogen-bonding-dynamics-eutectic-magic-angle-NMR-Brown-2020.pdf

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Managing emerging mutagenicity risks: Late stage mutagenic impurity control within the atovaquone second generation synthesis

Autor: Alec Simpson, Charles E. Wade, Elaine Smith, Amanda Giddings, Ben Bardsley, Clare McKinlay, Angela White, Stephen A. Hermitage, Nick Wooster, James Harvey, Emma Griva, Claire Lesurf, Andrew J. Edwards, Tran N. Pham, Michael Urquhart, Paul Oxley, Fiona King, Stuart G. Leach, Neil G. Stevenson

Publikováno v: Regulatory toxicology and pharmacology : RTP. 99

The mutagenic-impurity control strategy for a second generation manufacturing route to the non-mutagenic antipneumocystic agent atovaquone (2-((1R,4R)-4-(4-chlorophenyl)cyclohexyl)-3-hydroxynaphthalene-1,4-dione) 1 is described. Preliminary assessmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b91995dc2837643aa20493c124ccc4
https://pubmed.ncbi.nlm.nih.gov/30118726

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Measuring Nano- to Microstructures from Relayed Dynamic Nuclear Polarization NMR

Autor: Tran N. Pham, Anne Lesage, Mingxue Tang, Staffan Schantz, Judith Schlagnitweit, Etienne Socie, Lyndon Emsley, Arthur C. Pinon, Aaron J. Rossini, Pierrick Berruyer, Moreno Lelli

Publikováno v: Journal of Physical Chemistry C
Journal of Physical Chemistry C, 2017, 121 (29), pp.15993-16005. ⟨10.1021/acs.jpcc.7b04438⟩
Journal of Physical Chemistry C, American Chemical Society, 2017, 121 (29), pp.15993-16005. ⟨10.1021/acs.jpcc.7b04438⟩

We are grateful to Matthew Conley and Christophe Coperet from ETH Zurich for providing the mesoporous silica materials. We are grateful to Prof. P. Tordo, Dr. O. Ouari, and Dr. G. Casano (Aix-Marseille Universite, France) for providing the biradicals

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a5e58b562de926ab375b4200e8a3fd
https://hal.science/hal-01576889

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Probing Hydrogen Bonding in Cocrystals and Amorphous Dispersions Using 14N–1H HMQC Solid-State NMR

Autor: Dinu Iuga, Frederick G. Vogt, Andrew J. Edwards, Tran N. Pham, Andrew S. Tatton, Steven P. Brown

Publikováno v: Molecular Pharmaceutics. 10:999-1007

Cocrystals and amorphous solid dispersions have generated interest in the pharmaceutical industry as an alternative to more established solid delivery forms. The identification of intermolecular hydrogen bonding interactions in a nicotinamide palmiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef611d5437b03cabe681e171a3b993e5
https://doi.org/10.1021/mp300423r

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A risk-based statistical investigation of the quantification of polymorphic purity of a pharmaceutical candidate by solid-state 19F NMR

Autor: Simon A. Watson, Samantha J. Barry, Andrew J. Edwards, Tran N. Pham, Phil J. Borman

Publikováno v: Analytica Chimica Acta. 712:30-36

The DMAIC (Define, Measure, Analyse, Improve and Control) framework and associated statistical tools have been applied to both identify and reduce variability observed in a quantitative 19F solid-state NMR (SSNMR) analytical method. The method had be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd22ced4be67fbf9cd5de727e10c01cd
https://doi.org/10.1016/j.aca.2011.10.064

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Solid-State NMR Analysis of Organic Cocrystals and Complexes

Autor: Simon A. Watson, Mark Strohmeier, Andrew J. Edwards, Tran N. Pham, Jacalyn S. Clawson, Frederick G. Vogt

Publikováno v: Crystal Growth & Design. 9:921-937

Solid-state NMR (SSNMR) is capable of providing detailed structural information about organic and pharmaceutical cocrystals and complexes. SSNMR nondestructively analyzes small amounts of powdered material and generally yields data with higher inform

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16ae18bef8497fe927b0e585082a3cdb
https://doi.org/10.1021/cg8007014

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Formation and Characterization of Crystals Containing a Pleuromutilin Derivative, Succinic Acid and Water

Autor: Alan D. Jones, Joseph Sisko, Tran N. Pham, Matthew N. Johnson, Jeffrey Brum, Wenning Dai, Daniel B. Patience, Jacalyn S. Clawson, Royston C. P. Copley, Sonja Sharpe, Frederick G. Vogt

Publikováno v: Crystal Growth & Design. 8:4120-4131

An unusual pharmaceutical solid containing a pleuromutilin derivative, succinic acid and water is studied with a combination of physiochemical methods. The parent pleuromutilin derivative creates a host structure that contains large channels, which a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aba3aac6ef68379580615d830daf9166
https://doi.org/10.1021/cg8005713

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