Dissecting genomic regions and underlying candidate genes in groundnut MAGIC population for drought tolerance.

Autor: Sharma, Vinay^1,2 (AUTHOR), Mahadevaiah, Supriya S.³ (AUTHOR), Latha, Putta⁴ (AUTHOR), Gowda, S. Anjan³ (AUTHOR), Manohar, Surendra S.¹ (AUTHOR), Jadhav, Kanchan³ (AUTHOR), Bajaj, Prasad¹ (AUTHOR), Joshi, Pushpesh^1,2 (AUTHOR), Anitha, T.⁴ (AUTHOR), Jadhav, Mangesh P.³ (AUTHOR), Sharma, Shailendra² (AUTHOR), Janila, Pasupuleti¹ (AUTHOR), Bhat, Ramesh S.³ (AUTHOR), Varshney, Rajeev K.⁵ (AUTHOR), Pandey, Manish K.¹ (AUTHOR) manish.pandey@icrisat.org

Publikováno v: BMC Plant Biology. 11/5/2024, Vol. 24 Issue 1, p1-21. 21p.

Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus

Autor: Mahajan, A., Sim, X., Ng, H.J., Manning, A., Rivas, M.A., Highland, H.M., Locke, A.E., Grarup, N., Im, H.K., Cingolani, P., Flannick, J., Fontanillas, P., Fuchsberger, C., Gaulton, K.J., Teslovich, T.M., Rayner, N.W., Robertson, N.R., Beer, N.L., Rundle, J.K., Bork-Jensen, J., Ladenvall, C., Blancher, C., Buck, D., Buck, G., Burtt, N.P., Gabriel, S., Gjesing, A.P., Groves, C.J., Hollensted, M., Huyghe, J.R., Jackson, A.U., Jun, G., Justesen, J.M., Mangino, M., Murphy, J., Neville, M., Onofrio, R., Small, K.S., Stringham, H.M., Syvanen, A.C., Trakalo, J., Abecasis, G., Bell, G.I., Blangero, J., Cox, N.J., Duggirala, R., Hanis, C.L., Seielstad, M., Wilson, J.G., Christensen, C., Brandslund, I., Rauramaa, R., Surdulescu, G.L., Doney, A.S., Lannfelt, L., Linneberg, A., Isomaa, B., Tuomi, T., Jørgensen, M.E., Jørgensen, T., Kuusisto, J., Uusitupa, M., Salomaa, V., Spector, T.D., Morris, A.D., Palmer, C.N., Collins, F.S., Mohlke, K.L., Bergman, R.N., Ingelsson, E., Lind, L., Tuomilehto, J., Hansen, T., Watanabe, R.M., Prokopenko, I., Dupuis, J., Karpe, F., Groop, L., Laakso, M., Pedersen, O., Florez, J.C, Morris, A.P., Altshuler, D., Meigs, J.B., Boehnke, M., McCarthy, M.I., Lindgren, C.M., Gloyn, A.L., T2D-GENES Consortium (), GoT2D Consortium (Hrabě de Angelis, M., Gieger, C., Grallert, H., Huth, C., Kriebel, J., Meisinger, C., Meitinger, T., Müller-Nurasyid, M., Peters, A., Ried, J.S., Strauch, K., Strom, T.M.)

Publikováno v: PLoS Genet. 11:e1004876 (2015)
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
PLoS Genetics; 11(1), no e1004876 (2015)
PLoS Genetics

Genome wide association studies (GWAS) for fasting glucose (FG) and insulin (FI) have identified common variant signals which explain 4.8% and 1.2% of trait variance, respectively. It is hypothesized that low-frequency and rare variants could contrib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d5f33ccf3f315e91b395a158989e23c0
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-242802

Novel Insights into Psychosis and Antipsychotic Interventions: From Managing Symptoms to Improving Outcomes.

Autor: Sfera, Adonis^1,2,3 (AUTHOR) adonis.sfera@dsh.ca.gov, Imran, Hassan^1,2,3 (AUTHOR), Sfera, Dan O.^1,2,3 (AUTHOR), Anton, Jacob J.⁴ (AUTHOR), Kozlakidis, Zisis⁵ (AUTHOR) kozlakidisz@iarc.who.int, Hazan, Sabine⁶ (AUTHOR) drhazan@progenabiome.com

Publikováno v: International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 11, p5904. 24p.

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.

Autor: Flannick J; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Fuchsberger C; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Mahajan A; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Teslovich TM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Agarwala V; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Gaulton KJ; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Caulkins L; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Koesterer R; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Ma C; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Moutsianas L; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., McCarthy DJ; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Statistics, University of Oxford, Oxford, UK., Rivas MA; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Perry JRB; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Sim X; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Blackwell TW; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Robertson NR; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Rayner NW; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK., Cingolani P; School of Computer Science, McGill University, Montreal, Quebec, Canada.; McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada., Locke AE; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Tajes JF; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Highland HM; Human Genetics Center, The University of Texas Graduate School of Biomedical Sciences at Houston, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.; National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA., Chines PS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Lindgren CM; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Hartl C; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Chen H; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.; Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA., Huyghe JR; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., van de Bunt M; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Pearson RD; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Kumar A; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany.; Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany., Grarup N; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Gamazon ER; Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, Illinois, USA., Lee J; Department of Statistics, Seoul National University, Seoul, Republic of Korea., Chen Y; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Scott RA; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Below JE; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Chen P; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore., Huang J; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA., Go MJ; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Stitzel ML; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA., Pasko D; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Parker SCJ; Departments of Computational Medicine & Bioinformatics and Human Genetics, University of Michigan, Ann Arbor, Michigan, USA., Varga TV; Department of Clinical Sciences, Lund University Diabetes Centre, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden., Green T; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Beer NL; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Day-Williams AG; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK., Ferreira T; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Fingerlin T; Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, Colorado, USA., Horikoshi M; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Hu C; Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China., Huh I; Department of Statistics, Seoul National University, Seoul, Republic of Korea., Ikram MK; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.; The Eye Academic Clinical Programme, Duke-NUS Graduate Medical School, Singapore, Singapore., Kim BJ; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Kim Y; Department of Statistics, Seoul National University, Seoul, Republic of Korea., Kim YJ; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Kwon MS; Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea., Lee J; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Lee S; Department of Statistics, Seoul National University, Seoul, Republic of Korea., Lin KH; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Maxwell TJ; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Nagai Y; McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada., Wang X; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore., Welch RP; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Yoon J; Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital NHS Trust, Southall, Middlesex, UK., Barzilai N; Departments of Medicine and Genetics, Albert Einstein College of Medicine, New York, USA., Voight BF; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania-Perelman School of Medicine, Philadelphia, Pennsylvania, USA.; Department of Genetics, University of Pennsylvania-Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Han BG; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Jenkinson CP; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA.; Research, South Texas Veterans Health Care System, San Antonio, Texas, USA., Kuulasmaa T; Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland., Kuusisto J; Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.; Kuopio University Hospital, Kuopio, Finland., Manning A; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Ng MCY; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Palmer ND; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Balkau B; Centre for Research in Epidemiology and Population Health, Inserm U1018, Villejuif, France., Stančáková A; Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland., Abboud HE; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA., Boeing H; German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany., Giedraitis V; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden., Prabhakaran D; Centre for Chronic Disease Control, New Delhi, India., Gottesman O; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, USA., Scott J; National Heart and Lung Institute, Cardiovascular Sciences, Hammersmith Campus, Imperial College London, London, UK., Carey J; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Kwan P; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Grant G; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Smith JD; Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington, USA., Neale BM; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Purcell S; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Psychiatry, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, USA., Butterworth AS; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Howson JMM; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Lee HM; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Lu Y; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, USA., Kwak SH; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea., Zhao W; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Danesh J; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Lam VKL; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Park KS; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Republic of Korea., Saleheen D; Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Center for Non-Communicable Diseases, Karachi, Pakistan., So WY; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Tam CHT; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Afzal U; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Aguilar D; Cardiovascular Division, Baylor College of Medicine, Houston, Texas, USA., Arya R; Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas, USA., Aung T; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.; The Eye Academic Clinical Programme, Duke-NUS Graduate Medical School, Singapore, Singapore., Chan E; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore., Navarro C; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Spain.; Unit of Preventive Medicine and Public Health, School of Medicine, University of Murcia, Spain., Cheng CY; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.; The Eye Academic Clinical Programme, Duke-NUS Graduate Medical School, Singapore, Singapore., Palli D; Cancer Research and Prevention Institute (ISPO), Florence, Italy., Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA., Curran JE; South Texas Diabetes and Obesity Institute, Regional Academic Health Center, University of Texas Health Science Center at San Antonio/University of Texas Rio Grande Valley, Brownsville, Texas, USA., Rybin D; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Farook VS; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA., Fowler SP; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA., Freedman BI; Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Griswold M; Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, Mississippi, USA., Hale DE; Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas, USA., Hicks PJ; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Khor CC; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.; Division of Human Genetics, Genome Institute of Singapore, A*STAR, Singapore, Singapore., Kumar S; South Texas Diabetes and Obesity Institute, Regional Academic Health Center, University of Texas Health Science Center at San Antonio/University of Texas Rio Grande Valley, Brownsville, Texas, USA., Lehne B; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Thuillier D; CNRS-UMR8199, Lille University, Lille Pasteur Institute, Lille, France., Lim WY; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore., Liu J; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore.; Division of Human Genetics, Genome Institute of Singapore, A*STAR, Singapore, Singapore., Loh M; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Institute of Health Sciences, University of Oulu, Oulu, Finland.; Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Musani SK; Jackson Heart Study, University of Mississippi Medical Center, Jackson, Mississippi, USA., Puppala S; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA., Scott WR; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Yengo L; CNRS-UMR8199, Lille University, Lille Pasteur Institute, Lille, France., Tan ST; Department of Cardiology, Ealing Hospital NHS Trust, Southall, Middlesex, UK.; National Heart and Lung Institute, Cardiovascular Sciences, Hammersmith Campus, Imperial College London, London, UK., Taylor HA; Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA., Thameem F; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA., Wilson G; College of Public Services, Jackson State University, Jackson, Mississippi, USA., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.; The Eye Academic Clinical Programme, Duke-NUS Graduate Medical School, Singapore, Singapore., Njølstad PR; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Pediatrics, Haukeland University Hospital, Bergen, Norway., Levy JC; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK., Bonnycastle LL; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Schwarzmayr T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Fadista J; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden., Surdulescu GL; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Herder C; Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, Germany., Groves CJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Wieland T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Bork-Jensen J; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Brandslund I; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.; Department of Clinical Biochemistry, Vejle Hospital, Vejle, Denmark., Christensen C; Department of Internal Medicine and Endocrinology, Vejle Hospital, Vejle, Denmark., Koistinen HA; Department of Health, National Institute for Health and Welfare, Helsinki, Finland.; Abdominal Center: Endocrinology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland.; Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland., Doney ASF; Division of Cardiovascular and Diabetes Medicine, Medical Research Institute, Ninewells Hospital and Medical School, Dundee, UK., Kinnunen L; Department of Health, National Institute for Health and Welfare, Helsinki, Finland., Esko T; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.; Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA., Farmer AJ; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Hakaste L; Abdominal Center: Endocrinology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.; Folkhälsan Research Centre, Helsinki, Finland.; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland., Hodgkiss D; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Kravic J; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden., Lyssenko V; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden., Hollensted M; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jørgensen ME; Steno Diabetes Center, Gentofte, Denmark., Jørgensen T; Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup, Denmark.; Department of Public Health, Institute of Health Sciences, University of Copenhagen, Copenhagen, Denmark.; Faculty of Medicine, Aalborg University, Aalborg, Denmark., Ladenvall C; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden., Justesen JM; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Käräjämäki A; Department of Primary Health Care, Vaasa Central Hospital, Vaasa, Finland.; Diabetes Center, Vaasa Health Care Center, Vaasa, Finland., Kriebel J; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Rathmann W; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany., Lannfelt L; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden., Lauritzen T; Department of Public Health, Section of General Practice, Aarhus University, Aarhus, Denmark., Narisu N; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Linneberg A; Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup, Denmark.; Department of Clinical Experimental Research, Rigshospitalet, Glostrup, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Melander O; Department of Clinical Sciences, Hypertension and Cardiovascular Disease, Lund University, Malmö, Sweden., Milani L; Estonian Genome Center, University of Tartu, Tartu, Estonia., Neville M; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK., Orho-Melander M; Department of Clinical Sciences, Diabetes and Cardiovascular Disease, Genetic Epidemiology, Lund University, Malmö, Sweden., Qi L; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Qi Q; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, USA., Roden M; Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Division of Endocrinology and Diabetology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany., Rolandsson O; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Swift A; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Rosengren AH; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden., Stirrups K; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK., Wood AR; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Mihailov E; Estonian Genome Center, University of Tartu, Tartu, Estonia., Blancher C; High Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Carneiro MO; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Maguire J; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Poplin R; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Shakir K; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Fennell T; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., DePristo M; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., de Angelis MH; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; 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Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China., Ma RCW; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China., Pollin TI; Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, and Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA., Sandhu M; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Tandon N; Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India., Froguel P; CNRS-UMR8199, Lille University, Lille Pasteur Institute, Lille, France.; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK., Barroso I; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.; Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Teo YY; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore.; Life Sciences Institute, National University of Singapore, Singapore, Singapore.; Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore., Zeggini E; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, USA., Small KS; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Ried JS; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., DeFronzo RA; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA., Grallert H; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Glaser B; Endocrinology and Metabolism Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel., Metspalu A; Estonian Genome Center, University of Tartu, Tartu, Estonia., Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Walker M; The Medical School, Institute of Cellular Medicine, Newcastle University, Newcastle, UK., Banks E; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Gieger C; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; 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Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Buck G; High Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Trakalo J; High Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Buck D; High Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Prokopenko I; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK., Mägi R; Estonian Genome Center, University of Tartu, Tartu, Estonia., Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Farjoun Y; Data Sciences and Data Engineering, Broad Institute, Cambridge, Massachusetts, USA., Owen KR; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK., Gloyn AL; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Germany., Tuomi T; Abdominal Center: Endocrinology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.; Folkhälsan Research Centre, Helsinki, Finland.; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.; Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland., Kooner JS; Department of Cardiology, Ealing Hospital NHS Trust, Southall, Middlesex, UK.; National Heart and Lung Institute, Cardiovascular Sciences, Hammersmith Campus, Imperial College London, London, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK., Lee JY; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Park T; Department of Statistics, Seoul National University, Seoul, Republic of Korea.; Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea., Donnelly P; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Statistics, University of Oxford, Oxford, UK., Morris AD; Clinical Research Centre, Centre for Molecular Medicine, Ninewells Hospital and Medical School, Dundee, UK.; The Usher Institute to the Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Hattersley AT; University of Exeter Medical School, University of Exeter, Exeter, UK., Bowden DW; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Collins FS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Atzmon G; Departments of Medicine and Genetics, Albert Einstein College of Medicine, New York, USA.; Department of Natural Science, University of Haifa, Haifa, Israel., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital NHS Trust, Southall, Middlesex, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Laakso M; Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.; Kuopio University Hospital, Kuopio, Finland., Strom TM; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, Technische Universität München, Munich, Germany., Bell GI; Departments of Medicine and Human Genetics, The University of Chicago, Chicago, Illinois, USA., Blangero J; South Texas Diabetes and Obesity Institute, Regional Academic Health Center, University of Texas Health Science Center at San Antonio/University of Texas Rio Grande Valley, Brownsville, Texas, USA., Duggirala R; 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Blood Systems Research Institute, San Francisco, California, USA., Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Meigs JB; General Medicine Division, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA., Cox NJ; Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, Illinois, USA., Sladek R; McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, McGill University, Montreal, Quebec, Canada., Lander ES; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Gabriel S; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA., Meitinger T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, Technische Universität München, Munich, Germany., Groop L; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.; Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland., Abecasis G; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Scott LJ; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Morris AP; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Department of Biostatistics, University of Liverpool, Liverpool, UK., Kang HM; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA., Altshuler D; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.; Diabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Burtt NP; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Florez JC; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.; Diabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Boehnke M; 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Publikováno v: Scientific data [Sci Data] 2017 Dec 19; Vol. 4, pp. 170179. Date of Electronic Publication: 2017 Dec 19.

Insulin Secretion Defect in Children and Adolescents with Obesity: Clinical and Molecular Genetic Characterization.

Autor: Enders-Seidlitz, Helena¹ (AUTHOR), Raile, Klemens² (AUTHOR), Gong, Maolian³ (AUTHOR), Galler, Angela¹ (AUTHOR), Kuehnen, Peter¹ (AUTHOR), Wiegand, Susanna¹ (AUTHOR)

Publikováno v: Journal of Diabetes Research. 3/20/2024, Vol. 2024, p1-9. 9p.