Involvement of KLF4 in sulforaphane- and iberin-mediated induction of p21(waf1/cip1)

Autor: Traka MH (AUTHOR), Chambers KF (AUTHOR), Lund EK (AUTHOR), Goodlad RA (AUTHOR), Johnson IT (AUTHOR), Mithen RF (AUTHOR)

Publikováno v: Nutrition & Cancer. Jan/Feb2009, Vol. 61 Issue 1, p137-145. 9p.

Sulforaphane rewires central metabolism to support antioxidant response and achieve glucose homeostasis.

Autor: Bernuzzi F; Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom., Maertens A; Braunschweig Integrated Centre of System Biology, Technical University of Braunschweig, Braunschweig, Germany., Saha S; Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom., Troncoso-Rey P; Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom., Ludwig T; Braunschweig Integrated Centre of System Biology, Technical University of Braunschweig, Braunschweig, Germany., Hiller K; Braunschweig Integrated Centre of System Biology, Technical University of Braunschweig, Braunschweig, Germany., Mithen RF; The Liggins Institute-The University of Auckland, New Zealand., Korcsmaros T; Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom; Imperial College London, London, United Kingdom; Earlham Institute, Norwich Research Park, Norwich, United Kingdom., Traka MH; Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom. Electronic address: maria.traka@quadram.ac.uk.

Publikováno v: Redox biology [Redox Biol] 2023 Nov; Vol. 67, pp. 102878. Date of Electronic Publication: 2023 Sep 07.

Microbiomes of Urine and the Prostate Are Linked to Human Prostate Cancer Risk Groups.

Autor: Hurst R; Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK., Meader E; Microbiology Department, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK., Gihawi A; Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK., Rallapalli G; Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK., Clark J; Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK., Kay GL; Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK; Quadram Institute Biosciences, Norwich, UK., Webb M; Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK., Manley K; Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK; Department of Urology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK., Curley H; Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK., Walker H; Department of Urology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK., Kumar R; Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK., Schmidt K; Microbiology Department, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK., Crossman L; Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK; Quadram Institute Biosciences, Norwich, UK., Eeles RA; The Institute of Cancer Research, London, UK; Royal Marsden NHS Foundation Trust, London and Sutton, UK., Wedge DC; Oxford Big Data Institute, University of Oxford, Oxford, UK; University of Manchester, Manchester, UK., Lynch AG; School of Medicine, University of St Andrews, St Andrews, UK; School of Mathematics and Statistics, University of St Andrews, St Andrews, UK., Massie CE; Hutchison/MRC Research Centre, Cambridge University, Cambridge, UK., Yazbek-Hanna M; Department of Urology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK., Rochester M; Department of Urology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK., Mills RD; Department of Urology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK., Mithen RF; Quadram Institute Biosciences, Norwich, UK; Liggins Institute, University of Auckland, Grafton, Auckland, New Zealand., Traka MH; Quadram Institute Biosciences, Norwich, UK., Ball RY; Norfolk and Waveney Cellular Pathology Service, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK., O'Grady J; Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK; Quadram Institute Biosciences, Norwich, UK., Brewer DS; Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK; Earlham Institute, Norwich Research Park Innovation Centre, Norwich, UK., Wain J; Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK; Quadram Institute Biosciences, Norwich, UK., Cooper CS; Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK. Electronic address: colin.cooper@uea.ac.uk.

Publikováno v: European urology oncology [Eur Urol Oncol] 2022 Aug; Vol. 5 (4), pp. 412-419. Date of Electronic Publication: 2022 Apr 18.

Role of the Microbiome in Regulating Bone Metabolism and Susceptibility to Osteoporosis.

Autor: Cronin O; Rheumatic Diseases Unit, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XU, UK.; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XU, UK., Lanham-New SA; Nutrition, Food and Exercise Sciences Department, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK., Corfe BM; Population Health Sciences Institute, Human Nutrition Research Centre, Faculty of Medical Sciences, Newcastle University, Newcastle, NE2 4HH, UK., Gregson CL; MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK.; Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Darling AL; Nutrition, Food and Exercise Sciences Department, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK., Ahmadi KR; Nutrition, Food and Exercise Sciences Department, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK., Gibson PS; Department of Nutritional Sciences, King's College London, London, UK., Tobias JH; MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK.; Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Ward KA; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK., Traka MH; Food Databanks National Capability, Quadram Institute Bioscience, Norwich Research Park, Norwich, NR4 7UQ, UK., Rossi M; Department of Nutritional Sciences, King's College London, London, UK., Williams C; Molecular Gastroenterology Research Group, Academic Unit of Surgical Oncology, Department of Oncology and Metabolism, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, UK., Harvey NC; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK., Cooper C; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK., Whelan K; Department of Nutritional Sciences, King's College London, London, UK., Uitterlinden AG; Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands., O'Toole PW; School of Microbiology and APC Microbiome Ireland, University College Cork, Room 447, Food Science Building, Cork, T12 K8AF, Ireland., Ohlsson C; Sahlgrenska Osteoporosis Centre, Center for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Compston JE; Department of Medicine, Cambridge Biomedical Campus, Cambridge, UK., Ralston SH; Rheumatic Diseases Unit, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XU, UK. stuart.ralston@ed.ac.uk.; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XU, UK. stuart.ralston@ed.ac.uk.

Publikováno v: Calcified tissue international [Calcif Tissue Int] 2022 Mar; Vol. 110 (3), pp. 273-284. Date of Electronic Publication: 2021 Dec 06.

Modifying nutritional substrates induces macrovesicular lipid droplet accumulation and metabolic alterations in a cellular model of hepatic steatosis.

Autor: Gunn PJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Pramfalk C; Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden., Millar V; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Cornfield T; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Hutchinson M; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Johnson EM; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Nagarajan SR; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Troncoso-Rey P; Quadram Institute Bioscience, Norwich Research Park, UK., Mithen RF; Quadram Institute Bioscience, Norwich Research Park, UK., Pinnick KE; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Traka MH; Quadram Institute Bioscience, Norwich Research Park, UK., Green CJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Hodson L; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital Trusts, Oxford, UK.

Publikováno v: Physiological reports [Physiol Rep] 2020 Jul; Vol. 8 (13), pp. e14482.