Impaired Ca V 1.2 inactivation reduces the efficacy of calcium channel blockers in the treatment of LQT8.

Autor: Bamgboye MA; Department of Physiology, University of Maryland, School of Medicine, Baltimore, MD, United States of America., Traficante MK; Department of Physiology, University of Maryland, School of Medicine, Baltimore, MD, United States of America., Owoyemi J; Department of Physiology, University of Maryland, School of Medicine, Baltimore, MD, United States of America., DiSilvestre D; Department of Physiology, University of Maryland, School of Medicine, Baltimore, MD, United States of America., Vieira DCO; Department of Physiology, University of Maryland, School of Medicine, Baltimore, MD, United States of America., Dick IE; Department of Physiology, University of Maryland, School of Medicine, Baltimore, MD, United States of America. Electronic address: ied@som.umaryand.edu.

Publikováno v: Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2022 Dec; Vol. 173, pp. 92-100. Date of Electronic Publication: 2022 Oct 20.

Histone variant HTZ1 shows extensive epistasis with, but does not increase robustness to, new mutations.

Autor: Richardson JB; Center for Genomics and Systems Biology, Department of Biology, New York University, New York, New York, United States of America., Uppendahl LD, Traficante MK, Levy SF, Siegal ML

Publikováno v: PLoS genetics [PLoS Genet] 2013; Vol. 9 (8), pp. e1003733. Date of Electronic Publication: 2013 Aug 22.