Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Tracy Young-Pearse"'
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Amyloid β-protein (Aβ) plays an initiating role in Alzheimer’s disease (AD), but only a small number of groups have studied Aβ extracted from human brain. Most prior studies have utilized synthetic Aβ peptides, but the relevance of these test t
Externí odkaz:
https://doaj.org/article/af7ee4075a3f402cadc6dc3a355e04a5
Autor:
Yang You, Satoshi Muraoka, Mark P. Jedrychowski, Jianqiao Hu, Amanda K. McQuade, Tracy Young‐Pearse, Roshanak Aslebagh, Scott A. Shaffer, Steven P. Gygi, Mathew Blurton‐Jones, Wayne W. Poon, Tsuneya Ikezu
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 1, Pp n/a-n/a (2022)
Abstract In neurodegenerative diseases, extracellular vesicles (EVs) transfer pathogenic molecules and are consequently involved in disease progression. We have investigated the proteomic profiles of EVs that were isolated from four different human
Externí odkaz:
https://doaj.org/article/10a771972cb944f08b28b85ac902d334
Autor:
Ming Jin, Brian O’Nuallain, Wei Hong, Justin Boyd, Valentina N. Lagomarsino, Tiernan T. O’Malley, Wen Liu, Charles R. Vanderburg, Matthew P. Frosch, Tracy Young-Pearse, Dennis J. Selkoe, Dominic M. Walsh
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The optimal Aβ species to target for the potential treatment of Alzheimer’s disease has not yet been established. Here, the authors describe an in vitro assay that uses extracts from brain tissue from patients with Alzheimer’s disease, and appli
Externí odkaz:
https://doaj.org/article/1b248bb1ced34f1e829628bfcb182dd4
Autor:
Anna Krichevsky, Lien Nguyen, Zhiyun Wei, M. Silva, Sergio Barberán-Soler, Rosalia Rabinovsky, Christina Muratore, Jonathan Stricker, Colin Hortman, Tracy Young-Pearse, Stephen Haggarty
MicroRNAs (miRNAs) regulate fundamental biological processes by silencing mRNA targets and are dysregulated in many diseases. Therefore, miRNA replacement or inhibition can be harnessed as potential therapeutics. However, existing strategies for miRN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6de807fe331d7905fc7401198ed42a3
https://doi.org/10.21203/rs.3.rs-2617979/v1
https://doi.org/10.21203/rs.3.rs-2617979/v1
Autor:
Eugene Lee, Morgan Miller, Marty A. Fernandez, Elizabeth Berg, Adriana Prada, Jill Silverman, Tracy Young‐Pearse, Eric Morrow
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72ad87229ac1fa1a090a2773948b6cdd
https://doi.org/10.1002/alz.059990
https://doi.org/10.1002/alz.059990
Autor:
Hyo Lee, Aimee J Aylward, Richard V Pearse II, Yi‐Chen Hsieh, Zachary M Augur, Allison Knupp, Srilakshmi Goberdhan, Cheryl Pan, Nicholas T. Seyfried, David A Bennett, Philip L De Jager, Jessica E. Young, Tracy Young‐Pearse
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdb64be854043477358ee61d7d654876
https://doi.org/10.1002/alz.067209
https://doi.org/10.1002/alz.067209
Autor:
Yi‐Chen Hsieh, Joseph Negri, Amy He, Richard V Pearse II, Lei Liu, Duc M. Duong, Lori B. Chibnik, David A Bennett, Nicholas T. Seyfried, Tracy Young‐Pearse
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bad55b54c0a46e5d7ba5953e534f20d
https://doi.org/10.1002/alz.059823
https://doi.org/10.1002/alz.059823
Autor:
Masashi Fujita, Zongmei Gao, Lu Zeng, Cristin McCabe, Charles C. White, Bernard Ng, Gilad Sahar Green, Orit Rozenblatt-Rosen, Devan Phillips, Liat Amir-Zilberstein, Hyo Lee, Richard V. Pearse, Atlas Khan, Badri N. Vardarajan, Krzysztof Kiryluk, Chun Jimmie Ye, Hans-Ulrich Klein, Gao Wang, Aviv Regev, Naomi Habib, Julie A. Schneider, Yanling Wang, Tracy Young-Pearse, Sara Mostafavi, David A. Bennett, Vilas Menon, Philip L. De Jager
The relationship between genetic variation and gene expression in individual brain cell types and subtypes has remained elusive. Here, we generated single-nucleus RNA sequencing data from the dorsolateral prefrontal cortex of 424 individuals of advan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f17b25079865559b48f50c6e896785d
https://doi.org/10.1101/2022.11.07.515446
https://doi.org/10.1101/2022.11.07.515446
Publikováno v:
Genome Research.
Mosaic loss of Chromosome Y (LOY) is a common acquired structural mutation in the leukocytes of aging men that is correlated with several age-related diseases, including Alzheimer's disease (AD). The molecular basis of LOY in brain cells has not been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e267f07e9f6dddf920dccfb8f763072
https://doi.org/10.1101/gr.276409.121
https://doi.org/10.1101/gr.276409.121
Autor:
Lei, Liu, Bianca M, Lauro, Amy, He, Hyo, Lee, Sanjay, Bhattarai, Michael S, Wolfe, David A, Bennett, Celeste M, Karch, Tracy, Young-Pearse, Dennis J, Selkoe
Publikováno v:
Alzheimer'sdementia : the journal of the Alzheimer's Association.
Identifying CSF-based biomarkers for the β-amyloidosis that initiates Alzheimer's disease (AD) could provide inexpensive and dynamic tests to distinguish AD from normal aging and predict future cognitive decline.We developed immunoassays specificall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e13dc5e894d696216b24c380dacfefdd
https://pubmed.ncbi.nlm.nih.gov/35278341
https://pubmed.ncbi.nlm.nih.gov/35278341