Výsledky vyhledávání - "Tracy Withers"

Akademický článek

Zinc shapes the folding landscape of p53 and establishes a pathway for reactivating structurally diverse cancer mutants

Autor: Adam R Blanden, Xin Yu, Alan J Blayney, Christopher Demas, Jeung-Hoi Ha, Yue Liu, Tracy Withers, Darren R Carpizo, Stewart N Loh

Publikováno v: eLife, Vol 9 (2020)

Missense mutations in the p53 DNA-binding domain (DBD) contribute to half of new cancer cases annually. Here we present a thermodynamic model that quantifies and links the major pathways by which mutations inactivate p53. We find that DBD possesses t

Externí odkaz: https://doaj.org/article/414b92a82c8d4ddc9d7a0884046cf056

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Supplementary Tables S1-S5 from Combinatorial Therapy of Zinc Metallochaperones with Mutant p53 Reactivation and Diminished Copper Binding

Autor: Darren R. Carpizo, S. David Kimball, Stewart N. Loh, David A. Boothman, John Gilleran, Alan J. Blayney, Bing Na, Tracy Withers, Yue Liu, Adam R. Blanden, Anthony F. Bencivenga, Xin Yu, Saif Zaman

Supplementary tables to show combination index values for combination treatments of indicated compounds. Supplementary Table 1. Combination Index values for initial combination treatment of ZMC1 with chemotherapy drugs; Supplementary Table 2. Combina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b552ac3dcc2e7479c6659a9b74c1df4
https://doi.org/10.1158/1535-7163.22505851.v1

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Supplementary Figures S1-S10 from Combinatorial Therapy of Zinc Metallochaperones with Mutant p53 Reactivation and Diminished Copper Binding

Suppl. Fig. S1 display ZMC1 structure. Suppl. Fig. S2 showed no synergy in combination treatment of ZMC1 and Adriamycin or IR. Suppl. Fig. S3 showed synergy in Detroit 562 cells by combination treatment of ZMC1 and Irinotecan in the presence of GSH.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373924276ceb44d0f28384c120bb1228
https://doi.org/10.1158/1535-7163.22505854

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Supplementary methods from Combinatorial Therapy of Zinc Metallochaperones with Mutant p53 Reactivation and Diminished Copper Binding

Suppl. Methods included the methods used in the paper, Cell growth inhibition assay, Immunofluorescent staining, Synthesis of ZMC1, Synthesis of 2,2'-((2-Ethoxy-2-oxoethyl)azanediyl)diacetic acid (NTA-MEE) and NTA-DEE, Zn2+-Kd measurements by competi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7118ac2756632efdd25988ccd02b669d
https://doi.org/10.1158/1535-7163.22505848.v1

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Data from Zinc Metallochaperones Reactivate Mutant p53 Using an ON/OFF Switch Mechanism: A New Paradigm in Cancer Therapeutics

Autor: Darren R. Carpizo, Stewart N. Loh, S. David Kimball, Chang Chan, Joseph Bertino, Dirk Moore, Brian Buckley, John Gilleran, Hongxia Lin, Tracy Withers, Ashley T. Tsang, Ying Chen, Samuel Kogan, Xin Yu

Purpose: Zinc metallochaperones (ZMC) are a new class of anticancer drugs that reactivate zinc-deficient mutant p53 by raising and buffering intracellular zinc levels sufficiently to restore zinc binding. In vitro pharmacodynamics of ZMCs indicate th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1caa6c09622d14f31a294747889e9b
https://doi.org/10.1158/1078-0432.c.6527462.v1

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Supplementary figures and tables from Zinc Metallochaperones Reactivate Mutant p53 Using an ON/OFF Switch Mechanism: A New Paradigm in Cancer Therapeutics

Supplementary figures and tables Supplementary Fig. S1. Quantitative RT-PCR (qPCR) validation of the expression of MT1A, MT2A, and ZnT1 in TOV112D cells after ZMC1 treatment. Supplementary Fig. S2. Quantitative RT-PCR (qPCR) validation of the knockou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4704e5d0c18adc372b3f30e43e462a39
https://doi.org/10.1158/1078-0432.22470215.v1

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Abstract 1286: UNC5B promotes EMT and metastasis of pancreatic adenocarcinomas and expresses different isoforms that impact sensitivity to Netrin-1 blockade

Autor: Chris R. Harris, Orjola Prela, Lan Wang, Anthony Casabianca, Wade Narrow, Zachary Sechrist, Tracy Withers, Cory Shields, Asra Asad, Aram Hezel, Darren Carpizo

Publikováno v: Cancer Research. 83:1286-1286

The axonal guidance receptor UNC5B is considered to be a tumor suppressor because it promotes apoptosis in the absence of its protein ligand, NTN1. But we find that UNC5B is not a tumor suppressor of pancreatic ductal adenocarcinomas (PDAC), and inst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5553d2ac0bd9e90a3e452e927132ee99
https://doi.org/10.1158/1538-7445.am2023-1286

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Abstract B021: The axon guidance receptor UNC5B is a driver of pancreatic cancer metastasis

Autor: Chris Harris, Anthony Casabianca, Zach Sechrist, Cory Shields, Wade Narrow, Tracy Withers, Crissy Dudgeon, Mike O'Dell, Aram Hezel, Darren Carpizo

Publikováno v: Cancer Research. 82:B021-B021

Axon guidance pathways have often been linked to tumorigenesis by informatics analyses, but their roles in tumorigenesis are not well understood at a functional level. Here we show that axon guidance receptor UNC5B and its ligand, NTN1, promote the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::355c4f40d17b7122d195a9af420ad6e3
https://doi.org/10.1158/1538-7445.panca22-b021

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Abstract B020: Retinoic acid produced by hepatic stellate cells facilitates Netrin-1 mediated pancreatic cancer metastasis

Autor: Crissy Dudgeon, Anthony Casabianca, Chris Harris, Igor Astsaturov, Charline Ogier, Xiaoyang Su, Jason Pitarresi, Wade Narrow, Fady Soliman, Tracy Withers, Patrick Mehlen, Darren Carpizo

Publikováno v: Cancer Research. 82:B020-B020

A hallmark of pancreatic ductal adenocarcinoma (PDAC) is its proclivity for metastasis as evidenced by the fact that 85% are stage IV at diagnosis. This highlights the need to better understand the biology of metastatic PDAC and identify novel therap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::576c51205ca798c8c4ad0419182fc5db
https://doi.org/10.1158/1538-7445.panca22-b020

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