Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Tracy Varrieur"'
Autor:
Winnie, Sohn, Peter, Winkle, Joel, Neutel, You, Wu, Freeman, Jabari, Caitlin, Terrio, Tracy, Varrieur, Jingying, Wang, Jennifer, Hellawell
Publikováno v:
Clinical Therapeutics. 44:1237-1247
Olpasiran, an N-acetyl galactosamine-conjugated, hepatocyte-targeted, small interfering RNA, is being developed to reduce plasma lipoprotein (Lp)-(a) concentration by directly targeting the LPA gene. This study evaluated the pharmacokinetics, pharmac
Autor:
Michael J. Koren, Patrick Maurice Moriarty, Seth J. Baum, Joel Neutel, Martha Hernandez-Illas, Howard S. Weintraub, Monica Florio, Helina Kassahun, Stacey Melquist, Tracy Varrieur, Saptarsi M. Haldar, Winnie Sohn, Huei Wang, Mary Elliott-Davey, Brooke M. Rock, Tao Pei, Oliver Homann, Jennifer Hellawell, Gerald F. Watts
Publikováno v:
Nature Medicine. 28:96-103
Compelling evidence supports a causal role for lipoprotein(a) (Lp(a)) in cardiovascular disease. No pharmacotherapies directly targeting Lp(a) are currently available for clinical use. Here we report the discovery and development of olpasiran, a firs
Autor:
Huei Wang, Gerald F. Watts, Helina Kassahun, Patrick M. Moriarty, Joel M. Neutel, Mary Elliott-Davey, Michael J. Koren, Jennifer Hellawell, Winnie Sohn, Howard Weintraub, Seth J. Baum, Tracy Varrieur, Martha Hernandez-Illas
Publikováno v:
Circulation. 142
Introduction: Mendelian and epidemiological randomization studies have identified lipoprotein(a) [Lp(a)] as a risk factor for myocardial infarction and other atherosclerotic events. There are currently no approved medicines that selectively target Lp