RGD density along with substrate stiffness regulate hPSC hepatocyte functionality through YAP signalling

Autor: Samuel J.I. Blackford, Tracy T.L. Yu, Michael D.A. Norman, Adam M. Syanda, Michail Manolakakis, Dariusz Lachowski, Ziqian Yan, Yunzhe Guo, Elena Garitta, Federica Riccio, Geraldine M. Jowett, Soon Seng Ng, Santiago Vernia, Armando E. del Río Hernández, Eileen Gentleman, S. Tamir Rashid

Publikováno v: Gentleman, E, Rashid, T, Blackford, S, Jowett, G, Yan, Z, Yu, T, Norman, M, Guo, Y, Syanda, A, Riccio, F, Ng, S S, Manolakakis, M, Lachowski, D, Garrita, E, Vernia, S & de Rio Hernandez, A 2023, ' RGD density along with substrate stiffness regulate hPSC hepatocyte functionality through YAP signalling ', Biomaterials, vol. 293, 121982 . https://doi.org/10.1016/j.biomaterials.2022.121982

Human pluripotent stem cell-derived hepatocytes (hPSC-Heps) may be suitable for treating liver diseases, but differentiation protocols often fail to yield adult-like cells. We hypothesised that replicating healthy liver niche biochemical and biophysi

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http://hdl.handle.net/10044/1/102659